Acathinol Memantine, pills 20mg, 98pcs

Composition

Active ingredient:

memantine gilrochloride 20 mg;

Auxiliary substances:

lactose,

MCC,

colloidal silicon dioxide,

talc,

magnesium stearate,

Shell:

methacrylic acid copolymer,

sodium lauryl sulfate,

talc.

Pharmacological action

Pharmacodynamics

Being a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, it has a modulating effect on the glutamatergic system. Regulates ion transport, blocks calcium channels, normalizes the membrane potential, and improves the process of nerve impulse transmission. Improves cognitive processes, increases daily activity.

Pharmacokinetics

After oral use, Acatinol Memantine is rapidly and completely absorbed. The maximum concentration in the blood plasma is reached within 2-6 hours. No accumulation of the drug was observed in normal renal function. Elimination proceeds in two phases. The elimination half-life is 4-9 hours in the first phase and 40-65 hours in the second phase. It is excreted in the urine.

Indications

Alzheimer’s type dementia, vascular dementia, mixed dementia of all degrees of severity.

Contraindications

• individual hypersensitivity to the drug Akatinol Memantine;
• severe renal dysfunction;
• pregnancy;
• breastfeeding;
• children under 18 years of age (due to insufficient data).

With caution:

• thyrotoxicosis;
• epilepsy;
• convulsions (including in the anamnesis);
• myocardial infarction;
• heart failure.

Side effects

Adverse reactions are classified according to clinical manifestations (according to the lesion of certain organ systems) and frequency of occurrence:

and Hallucinations were observed mainly in patients with Alzheimer’s disease at the stage of severe dementia.

2 There are isolated reports of these adverse reactions occurring with the use of the drug in clinical practice (data obtained after the drug became commercially available).

Interaction

When used concomitantly with barbiturates, neuroleptics, anticholinergics, the effect of the latter may increase. When used together, it can change (increase or decrease) the effect of dantrolene or baclofen, so the dosage of drugs should be selected individually.

How to take, course of use and dosage

Acatinol Memantine is taken orally, with meals. The dosage regimen is set individually. It is recommended to start treatment with the minimum effective dose.

Adults with dementia during the 1st week of therapy — at a dose of 5 mg / day, the 2nd week-at a dose of 10 mg/day, the 3rd week-at a dose of 15-20 mg/day. If necessary, a further weekly dose increase of 10 mg is possible until the daily dose of 30 mg is reached.

The optimal dose is achieved gradually, with an increase in the dose every week.

Overdose

Symptoms:  increased severity of side effects.

Treatment:  gastric lavage, taking activated charcoal, symptomatic therapy.

Special instructions

The optimal dose is achieved gradually, with an increase in the dose every week.

Form of production

Film-coated tablets

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

4 years

Active ingredient

Memantine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Acquired Dementia, Alzheimer’s disease, Alcoholism, Stroke effects, Concussion and other traumatic brain injuries