Actiferrin, syrup 100ml

Composition

Active ingredient:

iron sulfate 3.42 g,

D, L-serine 2.58 g;

Auxiliary substances:

ascorbic acid,

invert syrup (72.7% dry syrup),

ethanol 96%,

raspberry flavor,

cream flavor,

purified water.

Pharmacological action

Actiferrin is an iron preparation. Iron is essential for the vital functions of the body: it is a part of hemoglobin, myoglobin, and a number of enzymes; reversibly binds oxygen and participates in a number of redox reactions; and stimulates erythropoiesis.

Part of the Actiferrin alpha-amino acid serine promotes more efficient absorption of iron and its entry into the systemic bloodstream, which leads to a rapid restoration of normal iron content in the body.

The inclusion of the alpha-amino acid serine in the composition allows you to reduce the dose of iron, providing better tolerability of the drug.

When using the drug Actiferrin, iron deficiency in the body is rapidly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.

Indications

• the drug is used for iron deficiency anemia
• increased body need for iron during pregnancy
• prevention of iron deficiency in children and infancy.

Contraindications

Hemolytic and aplastic anemia; increased iron content in the blood.

Side effects

From the digestive system:  rarely-a feeling of heaviness in the epigastric region, flatulence, constipation or diarrhea that disappears with a decrease in the dose.

Interaction

A specific antidote is deferoxamine (desferal).

Antacids, calcium supplements, drugs that reduce the acidity of gastric juice (including cimetidine, drugs containing carbonates, bicarbonates, phosphates, oxalates), pancreatin, pancreolipase, ethidron, caffeine, reduce the absorption of Actiferrin (the interval between taking these drugs should be 1-2 hours).

When used together, ascorbic acid increases iron absorption.

Actiferrin reduces the absorption of fluoroquinolones, penicillamine, and tetracyclines (these drugs are recommended to be taken 2 hours before or 2 hours after taking iron supplements).

High doses of iron preparations reduce the renal absorption of zinc preparations (the latter are recommended to be taken 2 hours after taking iron preparations).

How to take, course of use and dosage

of Actiferrin is taken orally immediately before meals or during meals. Syrup is taken with a small amount of liquid (fruit tea or water). If the attending physician has not prescribed other dosages, then you should strictly follow the instructions given below.

Syrup is the most convenient form for children over 2 years of age.

Daily dose: 5 ml per 12 kg of body weight. Preschool children: the average dose is 5 ml 2-3 times / day. School-age children: the average dose is 5 ml 1-2 times / day.

After reaching the normal values of serum iron and hemoglobin, treatment with the drug is continued for at least 8-12 weeks, prescribing a maintenance dose.

Note: to open the bottle, press the cap down and turn it in the direction of the arrow at the same time. After applying the medicine, install the cap and screw it tightly (prevents access for children).

Overdose

Symptoms: if the drug is accidentally taken in very high doses, weakness, fatigue, paresthesia, pallor of the skin, decreased blood pressure, palpitation, acrocyanosis, abdominal pain, diarrhea with blood admixture, vomiting, cyanosis, confusion, weak pulse, hyperthermia, lethargy, convulsive seizures, hyperventilation symptoms, coma are possible.

Signs of peripheral vascular collapse appear within 30 minutes after ingestion; metabolic acidosis, convulsions, fever, leukocytosis, coma-within 12-24 hours; acute renal and hepatic necrosis – after 2-4 days.

Treatment: before carrying out specific therapy, measures are taken to remove the drug that has not yet been absorbed from the stomach (gastric lavage), give milk, raw eggs. Specific therapy is carried out by prescribing deferoxamine (desferal) orally and parenterally. In acute poisoning,5-10 g of deferoxamine is given inside to bind iron that has not yet been absorbed from the gastrointestinal tract by dissolving the contents of 10-20 ampoules in drinking water.

With the development of poisoning phenomena, deferoxamine is administered intravenously slowly, children-15 mg / h, adults-5 mg / kg / h (up to 80 mg/kg/day); with mild poisoning-in/m, children – 1 g every 4-6 hours, adults-50 mg / kg (up to 4 g/day).

In severe cases, accompanied by the development of shock, intravenous drip use of the drug is performed at a dose of 1 g and symptomatic therapy is performed.

Hemodialysis is ineffective for the elimination of iron, but can be used to accelerate the elimination of the iron-deferoxamine complex, and can also be prescribed for oligo – and anuria. Peritoneal dialysis is possible.

Special instructions

Caution should be exercised when prescribing Actiferrin to patients with diabetes mellitus, taking into account the carbohydrates included in the preparation: 1 teaspoon of syrup contains 1.8 g of glucose, which is equivalent to 0.15 XE.

Actiferrin is not washed down with black tea, coffee, milk in order to avoid reducing iron absorption. In addition, a decrease in absorption can be caused by solid foods, bread, raw cereals, dairy products, eggs.

With the course use of Actiferrin, systematic monitoring of hemoglobin is necessary.

To prevent the appearance of reversible dark plaque on the teeth of patients, Actiferrin syrup should not be taken undiluted, and it is recommended to thoroughly brush your teeth after meals. When taking Actiferrin, fecal staining is noted in black, which is not clinically significant.

Use in patients with liver function disorders

Use with caution in patients with hepatitis, hepatic insufficiency. Use in patients with impaired renal function Caution should be used in patients with renal insufficiency.

Form of production

Syrup

Storage conditions

Store in a place protected from moisture at a temperature not exceeding 25°C.

Shelf life

2 years

Active ingredient

Iron Sulfate, Serine

Conditions of release from pharmacies

By prescription

Dosage form

solution for oral use

Description

Children as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor, For adults

Indications

Prevention of Iron Deficiency, Malnutrition, Anemia