Acyclovir-Acrihin, ointment 5% 5g

Composition

>of 100 g of ointment contains:

Active ingredient:  

acyclovir in terms of 100% substance – 5 g;

excipients:  

propylene glycol-40 g,

petrolatum-12.5 g,

petrolatum oil-7.5 g,

emulsion wax-5 g,

macrogol (polyethylene oxide 1500) -1 g,

purified water-up to 100 g.

Pharmacological action

Pharmacodynamics Antiviral drug is a synthetic analog of thymidine nucleoside. In infected cells containing viral thymidine kinase, phosphorylation occurs and conversion to acyclovir monophosphate. Under the influence of acyclovir guanylate cyclase, monophosphate is converted to diphosphate and under the action of several cellular enzymes – to triphosphate. The high selectivity of action and low toxicity to humans are due to the lack of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism. Acyclovir triphosphate, “embedded” in the DNA synthesized by the virus, blocks the reproduction of the virus. The specificity and very high selectivity of its action are also due to its predominant accumulation in cells affected by the herpes virus. Highly active against Herpes simplex virus type 1 and 2; Varicella zoster virus causing varicella zoster; Epstein-Barr virus. Moderately active against cytomegaloviruses. Pharmacokinetics When used on intact skin: absorption is minimal; not detected in blood and urine. On the affected skin: moderate absorption; in patients with normal renal function, the concentration in the blood serum is up to 0.28 mcg / ml, in patients with chronic renal failure (CRF) – up to 0.78 mcg/ml. It is excreted by the kidneys (up to 9.4% of the daily dose).

Indications

-skin infections caused by Herpes simplex virus types 1 and 2,

– genital herpes,

– shingles,

– chicken pox.

Use during pregnancy and lactation

The use of the drug is indicated only in cases where the intended benefit to the mother exceeds the potential risk to the fetus.

During the treatment period, it is necessary to decide whether to stop breastfeeding.

Contraindications

Hypersensitivity to acyclovir and other components of the drug.

With caution-pregnancy, lactation, dehydration, kidney failure.

Side effects

-hyperemia, dryness, peeling of the skin; – burning, inflammation when it gets on the mucous membranes. Allergic dermatitis may develop.

Interaction

When applied externally, no interaction with other drugs was detected. An increase in the effect is noted with the simultaneous appointment of immunostimulants.

How to take, course of use and dosage

Externally.

The drug is applied with clean hands or a cotton swab 5 times a day (every 4 hours) in a thin layer on the affected and adjacent skin areas.

Therapy should be continued until a crust forms on the vesicles, or until they completely heal. The duration of therapy is on average 5 days, maximum-10 days. If there is no effect, you should consult a doctor.

Overdose

Symptoms (if accidentally swallowed):  

– headache,

– neurological disorders,

– shortness of breath,

– nausea,

– vomiting,

– diarrhea,

– impaired kidney function,

– lethargy,

– convulsions,

– coma.

Treatment:  

– maintenance of vital functions,

– hemodialysis.

Special instructions

To achieve the maximum therapeutic effect, it is necessary to apply the drug as early as possible (at the first signs of the disease: burning, itching, tingling, a feeling of tension and redness). The ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, as it is possible to develop severe local inflammation. When treating genital herpes, avoid sexual contact or use condoms, as the use of acyclovir does not prevent transmission of the virus to partners.

Form of production

Ointment for external use.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Acyclovir

Dosage form

ointment

Description

Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Cold, Cold Sores