Composition
1 ampoule contains:
Active ingredient:
ranitidine hydrochloride 50 mg
Pharmacological action
Acyloc-antiulcer.
Blocks histamine H2-receptors of parietal cells of the gastric mucosa, inhibits basal and stimulated secretion of hydrochloric acid. Reduces the pH of the stomach contents, which leads to a decrease in pepsin activity.
Pharmacokinetics
Cmax — after 1-2 hours (regardless of food intake). Bioavailability — 50%. Binding to plasma proteins is 15%. It is partially metabolized in the liver. It is excreted by the kidneys. T1 / 2 — 2 hours
Indications
Peptic ulcer of the stomach and duodenum, ulcers (symptomatic, postoperative), Zollinger-Ellison syndrome, reflux esophagitis.
Prevention of gastrointestinal bleeding caused by stress, recurrent bleeding from peptic ulcers, Mendelssohn syndrome (aspiration of acidic stomach contents during anesthesia or childbirth).
Contraindications
Hypersensitivity to ranitidine or other components of the drug. Pregnancy and lactation. Children under 12 years of age.
With caution – renal and / or hepatic insufficiency, cirrhosis of the liver with a history of portosystemic encephalopathy, acute porphyria (including in the anamnesis).
Side effects
Headaches, fatigue, dizziness, bradycardia, AV block, allergic reactions (urticaria)
Interaction
Smoking tobacco reduces the effectiveness of ranitidine. Increases the concentration of metoprolol in the blood serum by 50%, while the half-life of metoprolol increases from 4.4 to 6.5 hours. Due to an increase in the pH of the stomach contents, simultaneous use may decrease the absorption of itraconazole and ketoconazole.
Inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, diazepam, lidocaine, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformin, metronidazole, calcium antagonists. Medications that depress bone marrow increase the risk of developing neutropenia.
When used concomitantly with antacids, sucralfate in high doses, it is possible to slow down the absorption of ranitidine, so the break between taking these drugs should be at least 2 hours.
How to take, course of use and dosage
Prevention of bleeding in “stress ulcers” and recurrent bleeding in patients with peptic ulcer of the stomach and duodenum.
Intramuscular injections: 50 mg (2 ml) every 6-8 hours.
Intravenous injections: 50 mg (2 ml) every 6-8 hours. The contents of the ampoule (50 mg) are diluted with 0.9% sodium chloride solution or dextrose for injection until a total volume of 20 ml is obtained and slowly administered for 5 minutes. The drug is prescribed parenterally until oral use is impossible.
Prevention of the development of Mendelssohn’s syndrome. 50 mg intramuscularly or intravenously 45-60 minutes before general anesthesia. For patients with renal insufficiency with creatinine clearance less than 50 ml / min, the recommended single dose is 25 mg.
Special instructions
Treatment with ranitidine can mask the symptoms associated with gastric carcinoma, so before starting treatment, it is necessary to exclude the presence of cancer-ulcers. Ranitidine should not be abruptly discontinued (rebound syndrome).
With long-term treatment of weakened patients under stress, bacterial lesions of the stomach are possible with the subsequent spread of infection. The safety and efficacy of ranitidine in children under 12 years of age have not been established.
During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
H2-histaminoreceptor blockers should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant decrease in their absorption. Taking ranitidine may cause a false positive reaction to a protein test in the urine.
H2-histaminoreceptor blockers can counteract the effect of pentagastrin and histamine on gastric acid-forming function, so it is not recommended to use H2-histaminoreceptor blockers during the 24 hours preceding the test.
H2-histaminoreceptor blockers can inhibit the skin reaction to histamine, thus leading to false positive results (before conducting diagnostic skin tests to detect an immediate allergic skin reaction, it is recommended to stop using Ng-histaminoreceptor blockers).
Storage conditions
In a dark place, at a temperature not exceeding 25 °C (do not freeze)
Shelf life
2 years
Active ingredient
Ranitidine
Conditions of release from pharmacies
By prescription
Dosage form
solution for injection and infusion
Description
For adults as prescribed by a doctor, Children over 12 years of age, Children as prescribed by a doctor
Indications
Gastrointestinal infections caused by Helicobacter Pylori, Gastric Ulcer and Duodenal ulcer
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Side effects of Acylok solution for intravenous and intramuscular use 25mg/ml 2ml ampoules, 10pcs.
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