Aethoxysklerol, ampoules 0.5%, 2ml, 5pcs

Composition

Active ingredient:

polydocanol 5 mg

Pharmacological action

Ethoxysclerol has a venosclerotic, local anesthetic effect. It damages the vascular endothelium, causing protein denaturation, and stimulates the rapid formation of a blood clot and its organization within 7 days.

Ethoxysclerol reduces the excitability of nerve endings and the conductivity of the pain pulse, ensuring the painlessness of sclerotherapy.

Volume of distribution — 24.5 l, binding to plasma proteins-64%, T_1/2-4 hours. Total Cl — 11.7 l/h, renal — 2.43 l/h, biliary — 3.14 l/h. With repeated injections, it does not accumulate.

Indications

Symptomatic treatment of functional asthenia.

Use during pregnancy and lactation

Contraindicated in the first trimester of pregnancy and after 36 weeks;

breastfeeding after the introduction of Ethoxysclerol is recommended to stop for 2-3 days.

Contraindications

Hypersensitivity to Etoxisclerol, bronchial asthma, diabetes mellitus

Side effects

When sclerosing varicose veins of the extremities: hyperpigmentation of the skin at the site of use of Ethoxysclerol.

When sclerosing hemorrhoids: transient pain.

With sclerosis of varicose veins of the esophagus and stomach: necrosis, ulceration and stenosis of the esophagus, exudation into the pleural cavity, dysphagia, fever, anaphylactic shock.

Interaction

Increases the arrhythmogenic activity of local anesthetics and drugs for general anesthesia.

How to take, course of use and dosage

Ethoxysclerol is administered strictly intravenously with a horizontal or 30-45 ° raised leg position.

The total dose of polydocanol for sclerosing varicose veins and hemorrhoids should not exceed 2 mg / kg of body weight per day.

For a patient weighing 70 kg, up to 140 mg of polydocanol can thus be administered (28 ml of 0.5% ethoxysclerol solution,14 ml of 1% ethoxysclerol solution,4.6 ml of 3% ethoxysclerol solution).

Overdose

Symptoms: with paravasal use – necrosis.

Treatment: use of 0.5-2 ml of 1% procaine solution or 5-20 ml of 0.9% NaCl solution in combination with hyaluronidase.

Special instructions

for CHF in the compensation phase and stable arterial hypertension are not contraindications for sclerosing therapy.

Sclerosing drugs should not be administered intravenously, as this can lead to severe necrosis and forced amputation.

In case of accidental intravenous use-insert 5-10 ml of 1-2% lidocaine or mepivacaine solution,500 IU of heparin into the needle left in the artery; wrap the limb with cotton wool and lower it down; hospitalize the patient in the vascular surgery department.

The introduction of sclerosing drugs into the veins of the facial part of the skull is carried out only according to strict indications.

Form of production

Solution for injection.

Storage conditions

In a dry place, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Polydocanol

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Varicose Veins, Hemorrhoids