Composition
Tablets coated with a film coating from white to white with a cream tint of color, round, biconvex, rough, on the break from white to white with a greenish-yellowish or cream tint of color.
1 tab. umifenovir hydrochloride 100 mg
Auxiliary substances:
lactose monohydrate – 0.1722 g,
povidone K 25 (polyvinyl-pyrrolidone medium molecular weight) – 0.0064 g,
crospovidone-0.0094 g,
colloidal silicon dioxide (aerosil) – 0.009 g,
magnesium stearate-0.003 g.
Composition of the film shell: Â
opadray II white [lactose monohydrate-36%, hypromellose-28%, titanium dioxide-26%, macrogol-4000 (polyethylene glycol 4000) – 10%] -0.012 g
Pharmacological action
Antiviral agent. Specifically suppresses influenza A and B viruses associated with severe acute respiratory syndrome. According to the mechanism of antiviral action, it belongs to fusion inhibitors (fusions), interacts with viral hemagglutinin and prevents the fusion of the lipid envelope of the virus and cell membranes. It has a moderate immunomodulatory effect.
It has interferoninducing activity, stimulates humoral and cellular immune responses, phagocytic function of macrophages, and increases the body’s resistance to viral infections. Reduces the incidence of complications associated with viral infection, as well as exacerbations of chronic bacterial diseases.
Therapeutic effectiveness in viral infections is manifested in reducing the severity of general intoxication and clinical phenomena, reducing the duration of the disease, and reducing the risk of complications.
It belongs to low-toxic compounds (LD50 >4 g / kg). It does not have any negative effects on the human body when administered orally at the recommended doses.
Indications
Prevention and treatment in adults and children: influenza A and B, acute respiratory viral infections, severe acute respiratory syndrome (including those complicated by bronchitis, pneumonia); secondary immunodeficiency states; complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.
Prevention of postoperative infectious complications and normalization of immune status.
Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years of age.
Recommendations for use
Inside, before meals.
Single dose (depending on age):
Age group |
Single dose of the drug |
from 3 to 6 years |
50 mg (1 tablet of 50 mg) |
from 6 to 12 years |
of age,100 mg (2 tablets of 50 mg or 1 tablet of 100 mg) |
older than 12 years and adults |
200 mg (4 tablets of 50 mg or 2 tablets of 100 mg) |
Indication |
Drug use schedule |
For children from 3 years of age and adults: |
|
Non-specific prevention during the epidemic of influenza and other acute respiratory |
viral infections in a single dose 2 times a week for 3 weeks. |
Non-specific prophylaxis in direct contact with patients with influenza and other acute respiratory |
viral infections in a single dose 1 time a day for 10-14 days. |
Treatment of influenza and other acute respiratory viral |
infections per day (every 6 hours) for 5 days. |
Complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection |
in a single dose 4 times in a single dose 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks. |
Prevention of postoperative infectious complications |
in a single dose 2 days before surgery, then on the 2nd and 5th days after surgery. |
Contraindications
Children under 3 years of age; hypersensitivity to umifenovir.
Side effects
Rarely: Â allergic reactions.
Special instructions
It does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy people of various professions, including those requiring increased attention and coordination of movements (transport drivers, operators, etc. ).
Storage conditions
At a temperature not exceeding 25 °C. Keep out of reach of children.
Shelf
life is 2 years. Do not use after the expiration date indicated on the package.
Active ingredient
Umifenovir
Dosage form
Tablets
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