Afrin, ecstro nasal spray 0.05% 15ml

Composition

Active ingredient:

oxymetazoline hydrochloride 0.5 mg.

Auxiliary substances:

cellulose microcrystalline and carmellose sodium (avicel RC-591) 30 mg,

sodium hydrogen phosphate 0,975 mg,

sodium dihydrogen phosphate monohydrate 5,525 mg,

disodium edetate dihydrate 0.3 mg,

macrogol-1450 50 mg,

povidone-K 29-32 30 mg,

benzyl alcohol 3 mg,

cineole 0.2 mg,

camphor 0.2 mg,

levomenthol 0.6 mg,

benzalkonium chloride solution 17% 1,471 mg,

polypropyleneglycol 5 mg,

purified water q. s. to 1 ml of

Pharmacological action

of alpha-given tool for local application. It has a vasoconstrictive effect. Oxymetazoline causes narrowing of the vessels of the nasal mucosa, paranasal sinuses and eustachian tube, which leads to a decrease in their edema and release of nasal breathing in allergic and/or infectious – inflammatory rhinitis (runny nose).

Due to the presence in the composition of the drug excipients (microcrystalline cellulose and carmellose sodium and povidone-K 29-32) Afrin® nasal spray ekstro follows from nose and dripping into the throat, as after injection into the nasal passages of the spray becomes more viscous and is held on the mucous membranes of the nose is more effective than standard aqueous solution.

Based on published clinical studies, intranasal use of an aromatic composition similar to that of a medicinal product containing levomenthol (also known as menthol), cineol (also known as eucalyptus) and camphor causes a temporary sensation of cooling of the nasal mucosa as a result of interaction with the trigeminal cold receptors on the surface of the mucosa. According to clinical studies, the drug begins to act within 1 minute and the effect lasts up to 12 hours.

Indications

Symptomatic treatment of rhinitis (runny nose) of allergic and/or infectious – inflammatory etiology, sinusitis, eustachitis, hay fever.

Contraindications

Hypersensitivity to sympathomimetic agents, to any component of the drug, atrophic rhinitis, simultaneous use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children under 6 years of age.

With caution

, coronary artery disease, arrhythmias, chronic heart failure, severe atherosclerosis, arterial hypertension, hyperthyroidism, diabetes mellitus, chronic renal failure, angle-closure glaucoma, prostatic hyperplasia with clinical symptoms, pregnancy, lactation.

Side effects

In general, the drug is well tolerated, and possible adverse events are usually mild and transient.

Transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing; increased blood pressure, increased anxiety, nausea, dizziness, headache, insomnia, palpitations, sleep disorders.

With prolonged use – tachyphylaxis, reactive hyperemia and atrophy of the nasal mucosa. Benzalkonium chloride, which is part of the drug, can cause local skin reactions.

Interaction

Slows down the absorption of local anesthetic drugs, extends the time of their action.

Combined use with other vasoconstrictor drugs increases the risk of side effects.

With simultaneous use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), maprotilin and tricyclic antidepressants-increased blood pressure.

How to take, course of use and dosage

Intranasally. Shake the spray bottle vigorously before each use.

Before applying the nasal spray for the first time, it is necessary to “calibrate” it by pressing the spray head several times. Adults and children older than 6 years – 2-3 injections in each nasal passage with an interval of 10-12 hours. The frequency of use can be increased up to 3 times a day in adults.

It is not recommended to exceed the indicated dose.

Overdose

With a significant overdose or accidental ingestion, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, central nervous system depression (drowsiness, decreased body temperature, bradycardia, decreased blood pressure, respiratory arrest and coma) are possible.

Treatment: symptomatic; in case of accidental ingestion-gastric lavage, activated charcoal. Vasopressor medications are contraindicated.

Description

of Afrin Extra 15 ml-Cold Spraywhat is Afrin Extra?Afrin Extra is a modern remedy for the common cold in the form of a spray with a patented formula, thanks to which it is fixed on the nasal mucosa, acting in the epicenter of congestion from the 1st minute. Afrin Extra does not flow out of the nose and does not run down the throat, helping to relieve anxiety from the 1st minute and facilitates nasal breathing. – Eliminates congestion-Facilitates nasal breathing-Combines 3 scents: eucalyptus, menthol, camphor Afrin Extra is indicated for symptomatic therapy: – Rhinitis( runny nose) – Allergic rhinitis-Sinusitis – Eustachiitis-Hay fever Distinctive features of Afrin Extra are: – Due to the presence of eucalyptus and menthol in the composition, it gives a feeling of freshness and facilitates breathing, helps to eliminate nasal congestion – Does not reduce the effectiveness of the natural protection of the nose(1)- Can act from the 1st minute-Can maintain its effect for up to 12 hours 1. Oxymetazoline in a concentration of 0.05% does not affect the activity of the ciliated epithelium. Zhang L et al. Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time. Ann Otol Rhinol Laryngol 2008 Feb; 117 (2): 12733.

Special instructions

With prolonged use (more than one week), the symptoms of nasal congestion may resume. If you need to continue treatment for more than 5 days, consult your doctor.

It is necessary to avoid contact with the drug in the eyes. The drug, when used correctly and in the recommended doses, does not affect driving vehicles and working with mechanisms, but if side effects such as dizziness occur, you should refrain from these activities.

Form of production

Nasal spray

Storage conditions

At a temperature of 2-30 °C.

Shelf life

5 years

Active ingredient

Oxymetazoline

Dosage form

nasal spray

Description

For adults and Children over 6 years of age

Indications

Flu, Runny Nose, Sinusitis, Allergic Runny Nose, Otitis Media, Cold