Akriderm GK, cream 0.064%, 30g

Composition

Cream for external use 1 g:

– betamethasone dipropionate 640 mcg,

– clotrimazole 10 mg,

– gentamicin sulfate 1 mg.

Auxiliary substances:  

petroleum jelly,

propylene glycol,

medical vaseline oil,

cetostearyl alcohol,

macrogol cetostearyl ether,

trilon B,

sodium dihydrogen phosphate dihydrate (monosubstituted 2-water sodium phosphate),

purified water.

Pharmacological action

Pharmaceutical group:

glucocorticosteroid+antibiotic-aminoglycoside+ antifungal agent.

Pharmaceutical effect:

Akriderm GK is a combined drug that has anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) effects. Betamethasone dipropionate is a glucocorticosteroid that has anti-inflammatory, anti-allergic, anti-exudative, anti-edematous and antipruritic effects. It inhibits the accumulation of white blood cells, the release of lysosomal enzymes and pro-inflammatory mediators in the inflammatory focus, inhibits phagocytosis, reduces vascular-tissue permeability, and prevents the formation of inflammatory edema.

Clotrimazole has an antifungal effect due to a violation of the synthesis of ergosterol, which is an integral part of the fungal cell membrane. Active with respect to: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare). Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides.

It has a bactericidal effect against pathogens of primary and secondary bacterial skin infections. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerugenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp. (sensitive strains of beta-and alpha-hemolytic streptococcus group A), Staphylococcus spp. (coagulase-positive, coagulase-negative, and some penicillinase-producing strains).

Indications

Treatment of dermatoses complicated by primary and / or secondary infection, pityriasis versicolor, limited and diffuse neurodermatitis, dermatomycosis (including inguinal, foot) caused by drug-sensitive pathogens.

Use during pregnancy and lactation

The safety of topical use of glucocorticosteroids in pregnant women has not been established; the use of drugs of this group during pregnancy is justified only if the potential benefit outweighs the possible risk. During pregnancy, drugs of this group should not be used in high doses or for a long time.

It has not been established whether topical use of glucocorticosteroids can cause their appearance in the mother’s milk, so the question of stopping breastfeeding should be decided.

Contraindications

-Hypersensitivity to any of the components of the drug;

– skin tuberculosis;

– skin manifestations of syphilis;

– chickenpox;

– herpes simplex;

– skin post-vaccination reactions;

– open wounds;

– lactation and children under 1 year of age;

– in the treatment of external otitis — perforation of the eardrum.

Side effects

Topical application of glucocorticosteroids may cause: burning sensation, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis.

With prolonged use, as well as the use of occlusive dressings — maceration of the skin, secondary infection, skin atrophy, sweating, purpura.

When applied to large body surfaces, mainly in children, systemic side effects of glucocorticosteroids (hyperglycemia, glucosuria, reversible suppression of the adrenal cortex, manifestation of Cushing’s syndrome) and gentamicin (nephrotoxic and ototoxic effects) may occur.

If you experience side effects that are not described in the instructions, you should consult a doctor.

Interaction

Interaction of the drug with other drugs was not detected.

How to take, course of use and dosage

Externally.

Akriderm ® GC is applied in a thin layer to the affected area of the skin 2 times a day-in the morning and in the evening. Another frequency of use can be determined by the doctor, based on the severity of the disease. In mild cases, it is sufficient to apply the cream, usually once a day; for more severe lesions, more frequent use may be required. The duration of treatment depends on the effectiveness and tolerability of the therapy and is 2-4 weeks. If clinical improvement does not occur, the diagnosis should be clarified.

Overdose

Acute overdose is unlikely, however, with excessive or prolonged use of the drug, a chronic overdose is possible, accompanied by signs of hypercorticism: hyperglycemia, glucosuria, reversible suppression of the adrenal cortex, manifestation of Cushing’s syndrome.

Treatment.

Appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual discontinuation of the drug is recommended.

Special instructions

If there are signs of hypersensitivity or skin irritation associated with the use of the drug, treatment should be discontinued and appropriate therapy should be selected for the patient.

Systemic corticosteroid absorption is possible with prolonged treatment, when the drug is applied to large skin surfaces, when occlusive dressings are used, and also in children.

Atrophic changes may occur on the skin of the face more often than on other body surfaces after prolonged treatment with topical glucocorticosteroids. Akriderm ® GC is not intended for use in ophthalmology. Avoid contact with eyes. With prolonged use of the drug, its cancellation should be carried out gradually.

Product form

Cream.

Active ingredient

Betamethasone, Gentamicin, Clotrimazole

Dosage form

cream

Description

Children as prescribed by a doctor, Pregnant women as prescribed by a doctor, Adults, Children over 2 years of age

Indications

Allergy, Neurodermatitis, Eczema, Dermatitis, Psoriasis, Dermatosis