Allokine-alpha lyophilizate for subcutaneous use 1mg ampoules, 6pcs

Composition

Per 1 ampoule: Alloferon [Histidyl-glycyl-valyl-seryl-glycyl-histidyl-glycyl-glutaminyl-histidyl-glycyl-valyl-histidyl-glycine] 1,0 mg

Pharmacological action

Pharmacotherapy group: antiviral, immunomodulatory agent

ATX code J05AX, L03A

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Alloferon is an oligopeptide. By the nature of its pharmacological action, it is most similar to interferon alpha. Alloferon is an effective inducer of endogenous interferon synthesis and an activator of the natural killer system. It can stimulate recognition and lysis of defective cells by cytotoxic lymphocytes. Experiments have demonstrated high efficacy against infections caused by influenza A and B viruses, hepatitis B and C, herpes types 1 and 2, and human papilloma. Alloferon does not have general toxicity, allergenic properties, mutagenic and carcinogenic effects, does not have an embryotoxic effect and does not affect the reproductive function.

Pharmacokinetics

It quickly penetrates into the blood, where it interacts with immunocompetent cells, after which it is difficult to determine the concentration of Alloferon due to the close structural similarity of its metabolites with serum proteins. An increase in the interferon concentration was observed 2 hours after use of the drug and remained at a high level (2-2.5 times higher than the usual background level) for 6-8 hours, reaching the initial values by the end of the day. Increased functional activity of natural killers was observed within 7 days after drug use.

Indications

Chronic papillomavirus infection caused by oncogenic human papillomavirus, chronic recurrent herpes types 1 and 2, as part of the complex therapy of moderate (jaundice) form of acute hepatitis B.

Contraindications

Hypersensitivity, pregnancy and breast-feeding (stop for the duration of treatment), severe autoimmune diseases.

Children’s age.

Side effects

In some cases, weakness, dizziness, and the formation of new rash elements (with a herpetic infection) are possible.

Interaction

In the treatment of chronic recurrent genital herpes, it can be prescribed in combination with acyclovir and its derivatives (the drugs have different mechanisms of action and complement each other in the treatment of viral infection). In acute hepatitis B, the drug is prescribed against the background of generally accepted basic therapy.

Interaction with other drugs was not detected.

How to take, course of use and dosage

The drug is administered subcutaneously. The standard course of treatment for infections caused by oncogenic types of human papillomavirus includes injections of the drug at a dose of 1 mg every other day, for a total of 6 injections. The standard course of treatment for recurrent herpes includes injections of the drug at a dose of 1 mg every other day, for a total of 3 injections per course. In moderate forms of acute hepatitis B, the drug is administered after verification of the diagnosis at a dose of 1 mg 3 times a week for 3 weeks (a total of 9 injections). To prepare the solution for injection, use 1 ml of 0.9% sodium chloride solution as a solvent.

Overdose

To date, no cases of overdose of the drug have been established.

Description

Lyophilized powder or porous mass of white color. Hygroscopic.

Special instructions

In monotherapy, Allokin-alpha is recommended for the treatment of papillomavirus infection caused by oncogenic types of the virus, in the absence of clinical and subclinical lesions of the cervix and anogenital region. As part of complex therapy – for the treatment of clinical and subclinical forms of lesions of the cervix and anogenital region with papillomavirus infection caused by oncogenic types of the virus. Treatment of chronic recurrent herpes types 1 and 2 is recommended to start at the very first signs of the disease. With hepatitis B – no later than the 7th day after the onset of jaundice.

Impact on the ability to drive a car and work with machineryIf you experience dizziness, you should refrain from driving and working with equipment.

Form of production

Lyophilizate for the preparation of a solution for subcutaneous use of 1,0 mg. 1,0 mg in an ampoule of colorless glass. 1,2,3,5 or 10 ampoules are placed in a contour cell package. 1 or 2 contour cell packages together with the instructions for use are placed in a pack of cardboard

Storage conditions

Store in a dark place at a temperature of 2 to 8 °C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date.

Active ingredient

Alloferon

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Genital Herpes, Cold Sores, Flu, Hepatitis