Amlodipine pills 5mg, 30pcs

Composition

1 tablet contains amlodipine (in the form of bezylate) 5 mg;

excipients:

potato starch,

lactose,

microcrystalline cellulose,

magnesium stearate,

calcium stearate.

Pharmacological action

Amlodipine is a class II selective calcium channel blocker. The antihypertensive effect is due to a direct relaxing effect on the smooth muscles of blood vessels.

It is assumed that the antianginal effect of amlodipine is associated with its ability to dilate peripheral arterioles; this leads to a decrease in OPSS, and reflex tachycardia does not occur. As a result, the myocardium’s oxygen demand and energy consumption by the heart muscle decreases.

On the other hand, amlodipine appears to cause dilation of large-caliber coronary arteries and coronary arterioles in both intact and ischemic areas of the myocardium. This ensures oxygen supply to the myocardium during coronary artery spasms.

Indications

Arterial hypertension (including in combination therapy), stable angina, unstable angina (including Prinzmetal angina).

Contraindications

Severe arterial hypotension. Hypersensitivity to dihydropyridine derivatives.

Side effects

Fromthe side of the cardiovascular system:  possible peripheral edema, palpitations, hyperemia of the skin; when used in high doses – hypotension, arrhythmias, shortness of breath.

From the digestive system:  nausea, abdominal pain; rarely gum hyperplasia.

From the central nervous system:  possible headaches, fatigue, drowsiness, dizziness.

Allergic reactions:  skin rash, itching.

Interaction

When used simultaneously Amlodipine with other antihypertensive drugs may increase the hypotensive effect; with means for inhalation anesthesia-may increase the hypotensive effect; with lithium preparations-possible manifestations of neurotoxicity, including nausea, vomiting, diarrhea, ataxia, trembling and/or tinnitus; with sympathomimetics – may reduce the hypotensive effect.

Indometacin and other NSAIDs may reduce the hypotensive effect of amlodipine by inhibiting prostaglandin synthesis in the kidneys and / or causing fluid retention.

How to take, course of use and dosage

For adults, when taken orally, the initial dose is 5 mg 1 time/day.

If necessary, the dose can be increased.

Maximum dose:  when taken orally-10 mg / day.

Overdose

Symptoms: marked decrease in blood pressure, excessive peripheral vasodilation, tachycardia.

Treatment: gastric lavage, use of activated charcoal, maintenance of the cardiovascular system, monitoring of heart and lung function, elevated position of the extremities, monitoring of the volume of circulating blood and diuresis. To restore vascular tone – the use of vasoconstrictor drugs (in the absence of contraindications to their use); to eliminate the consequences of calcium channel blockade – intravenous use of calcium gluconate. Hemodialysis is ineffective.

Special instructions

It is used with caution in cases of liver dysfunction, aortic stenosis, and chronic heart failure.

Patients with impaired renal function, as well as elderly patients, do not need to reduce the dose. It is possible to use amlodipine for the treatment of patients with dilated (non-ischemic) cardiomyopathy accompanied by severe chronic heart failure.

There are no clinical data on the use of amlodipine in children.

Storage conditions

Store in a dry place at a temperature not exceeding 25°C, out of the reach of children.

Shelf

life is 2 years.

Active ingredient

Amlodipine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Angina, Hypertension