Amosin, pills 0.25g, 10pcs

Composition

Active ingredient:

amoxicillin trihydrate (in terms of amoxicillin) – 0.25 g.

Auxiliary substances:

potato starch,

magnesium stearate,

talc.

collidone 90F (povidone),

calcium stearate.

Pharmacological action

Antibacterial bactericidal acid-resistant agent of a wide spectrum of action from the group of semi-synthetic penicillins. It inhibits transpeptidase, disrupts the synthesis of peptidoglycan (a cell wall support protein) during division and growth, and causes bacterial lysis.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp; and aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Penicillinase-producing microorganisms are resistant to amoxicillin. The action develops in 15-30 minutes after use and lasts for 8 hours.

Indications

Bacterial infections caused by sensitive microflora: infections of the respiratory tract and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media; bronchitis, pneumonia), genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis), gastrointestinal tract (peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis), infections skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), dysentery, salmonellosis, salmonella transmission, meningitis, endocarditis (prevention), sepsis.

Contraindications

Hypersensitivity (including to other penicillins, cephalosporins, carbapenems), allergic diathesis, bronchial asthma, pollinosis, infectious mononucleosis, lymphocytic leukemia, liver failure, a history of gastrointestinal diseases (especially colitis associated with the use of antibiotics), lactation.

With caution-pregnancy, renal failure, a history of bleeding.

Side effects

Allergic reactions: urticaria, skin hyperemia, erythema, angioedema, rhinitis, conjunctivitis are possible; rarely-fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome; reactions similar to serum sickness; in isolated cases – anaphylactic shock.

From the digestive system: dysbiosis, taste changes, vomiting, nausea, diarrhea, stomatitis, glossitis, impaired liver function, moderate increase in the activity of “hepatic” transaminases, pseudomembranous enterocolitis.

Nervous system disorders: agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, convulsive reactions.

Laboratory parameters: leukopenia, neutropenia, thrombocytopenic purpura, anemia.

Others: shortness of breath, tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Interaction

Antacids, glucosamine, laxatives, food, aminoglycosides-slow down and reduce absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) have an antagonistic effect.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, drugs that produce paroaminobenzoic acid in the process of metabolism, ethinyl estradiol – the risk of breakthrough bleeding.

Diuretics, allopurinol, oxifenbutazone, phenylbutazone, nonsteroidal anti-inflammatory drugs; drugs that block tubular secretion-reducing tubular secretion, increase the concentration.

Allopurinol increases the risk of developing a skin rash.

Reduces the clearance and increases the toxicity of methotrexate.

Increases digoxin absorption.

How to take, course of use and dosage

Inside, before or after a meal.

Adults and children over 10 years of age (with a body weight of more than 40 kg) are prescribed 0.5 g 3 times a day; in severe cases of infection-0.75-1 g 3 times a day. Children aged 5-10 years are prescribed 0.25 g 3 times a day; 2-5 years-0.125 g 3 times a day; younger than 2 years-20 mg / kg 3 times a day. The course of treatment is 5-12 days.

In acute uncomplicated gonorrhea,3 g is prescribed once; in the treatment of women, repeated use of the indicated dose is recommended.

For acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, for gynecological infectious diseases for adults-1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

For leptospirosis adults – 0.5-0.75 g 4 times a day for 6-12 days.

In case of Salmonella transmission to adults-1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis with minor surgical interventions, adults – 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function with a creatinine clearance of 15-40 ml / min, the interval between doses is increased to 12 hours; with a creatinine clearance below 10 ml/min, the dose is reduced by 15-50%; with anuria, the maximum dose is 2 g / day.

Overdose

Symptoms: nausea, vomiting, diarrhea, impaired water and electrolyte balance (as a result of vomiting and diarrhea). Treatment: gastric lavage, activated charcoal, saline laxatives, preparations for maintaining water and electrolyte balance; hemodialysis.

Special instructions

During the course of treatment, it is necessary to monitor the state of function of the hematopoietic organs, liver and kidneys.

It is possible to develop superinfection due to the growth of microflora that is insensitive to it, which requires a corresponding change in antibacterial therapy.

In the treatment of patients with bacteremia, a bacteriolysis reaction (Yarish-Gerksheimer reaction) may develop.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of mild diarrhea during the course of treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin-or attapulgite-containing antidiarrheal agents can be used. If you have severe diarrhea, you should consult a doctor.

Treatment must continue for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin at the same time, other or additional methods of contraception should be used if possible.

Form of production

Pills.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Amoxicillin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, Pregnant women as prescribed by a doctor, Children over 3 years of age, Children as prescribed by a doctor

Indications

Otitis Media, Urinary Tract Infections, Bronchitis, Respiratory Tract Infections, Biliary Tract Infections, Intestinal Infections, Pharyngitis, Tonsillitis, Skin Infections, Sore Throat