Amosin, powder 250mg/3g, 10pcs

Composition

1 sachet contains amoxicillin (in the form of trihydrate) 250 mg

Pharmacological action

Amosin is a broad-spectrum antibiotic of the semisynthetic penicillin group. It acts bactericidal. It inhibits transpeptidase, disrupts the synthesis of peptidoglycan (the cell wall support polymer) during division and growth, and causes bacterial lysis. Acid-resistant.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp. ; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori, Klebsiella spp.

Penicillinase-producing microorganisms are resistant to amoxicillin. The action develops in 15-30 minutes after use and lasts for 8 hours

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: – respiratory infections (including bronchitis, pneumonia);- ENT infections (including sinusitis, pharyngitis, tonsillitis, acute otitis media);- infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);- gynecological infections (including endometritis, cervicitis);- gastrointestinal infections (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);- skin and soft tissue infections (including erysipelas, impetigo, secondarily infected dermatoses);— leptospirosis;- listeriosis;- Lyme disease (borreliosis);- dysentery— – salmonellosis, salmonella transmission;— meningitis— – endocarditis (prevention);- sepsis

Contraindications

-allergic diathesis;— bronchial asthma, pollinosis— – infectious mononucleosis;- lymphocytic leukemia;— liver failure— – a history of gastrointestinal diseases (especially colitis associated with the use of antibiotics);- lactation period (breastfeeding);- hypersensitivity to the components of the drug;- hypersensitivity to other penicillins, cephalosporins, carbapenems);

With caution, the drug should be prescribed during pregnancy, renal failure, as well as with a history of bleeding.

Side effects

Allergic reactions: possibly-urticaria, skin hyperemia, erythema, angioedema, rhinitis, conjunctivitis; rarely-fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, reactions similar to serum sickness; in isolated cases – anaphylactic shock. From the digestive system:  dysbiosis, taste changes, vomiting, nausea, diarrhea, stomatitis, glossitis, impaired liver function, moderate increase in the activity of hepatic transaminases; rarely – pseudomembranous enterocolitis. From the central nervous system and peripheral nervous system:  agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, convulsive reactions. From the urinary system:  rarely-interstitial nephritis. From the hematopoietic system:  leukopenia, neutropenia, thrombocytopenic purpura, anemia. Other services:  shortness of breath, tachycardia, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

How to take, course of use and dosage

Amosin is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the patient’s age.

Adults and children over 10 years of age (with a body weight >40 kg) are prescribed 500 mg 3 times a day, with a severe course of the disease-0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, at the age of 2 to 5 years – 125 mg 3 times a day, at the age of 2 years-20 mg / kg / day in 3 doses. The course of treatment is 5-12 days. For children under 5 years of age, the drug is prescribed in the form of a suspension.

For the treatment of acute uncomplicated gonorrhea Amosin is prescribed at a dose of 3 g once; in the treatment of women, it is recommended to repeat the specified dose.

For acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, for gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

In case of Salmonella transmission to adults-1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis with minor surgical interventions, adults are prescribed a dose of 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function (creatinine clearance from 15 to 40 ml / min), the interval between doses is increased to 12 hours, in end-stage chronic renal failure (CC

In a clean glass, pour boiled and cooled water in the required amount, then pour out the contents of one package and mix until a homogeneous suspension is obtained. A dose of 125 mg – 2.5 ml of water, a dose of 250 mg-5 ml of water, a dose of 500 mg-10 ml of water.

After taking the cup, rinse it with water, dry it and store it in a dry, clean place.

Special instructions

During the course of treatment with Amosin, it is necessary to monitor the state of function of the hematopoietic organs, liver and kidneys.

It is possible to develop superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

When treating patients with bacteremia, a bacteriolysis reaction (Yarish-Gerksheimer reaction) rarely develops.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of mild diarrhea with Amosin, antidiarrheal medications that reduce intestinal motility should be avoided; kaolin-or attapulgite-containing antidiarrheal agents can be used. In case of severe diarrhea, it is necessary to conduct a differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin at the same time, additional methods of contraception should be used, if possible.

Storage conditions

Keep out of reach of children, in a dry place protected from light. The powder for preparing the suspension should be stored at a temperature not exceeding 25°C.

Shelf life

2 years

Active ingredient

Amoxicillin

Conditions of release from pharmacies

By prescription

Dosage form

powder for oral use

Description

For adults as prescribed by a doctor, for children as prescribed by a doctor

Indications

Biliary Tract Infections, Pharyngitis, Respiratory Tract Infections, Tonsillitis, Otitis Media, Intestinal Infections, Skin Infections, Bronchitis, Urinary Tract Infections, Sore Throat