Amoxiclav Quicktab dispersible pills 875mg+125mg, 14pcs

Composition

1 tablet (1000 mg) contains amoxicillin (in the form of trihydrate) 875 mg and clavulanic acid (in the form of potassium salt) 125 mg

Pharmacological action

Amoxiclav Kviktab is a broad-spectrum antibiotic; it contains semi-synthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid.

Clavulanic acid inhibits most clinically significant b-lactamases (types 2,3,4, and 5 – according to the Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, and Bacteroides spp. Inactive against type 1 b-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

This combination provides a high bactericidal activity of Amoxiclav (including against strains of microorganisms resistant to amoxicillin). Clavulanic acid, having a higher affinity for b-lactamase than amoxicillin, forms a stable deactivated complex with the enzyme, preventing the enzymatic degradation of amoxicillin under the action of b-lactamases.

Thus, Amoxiclav acts bactericidally on a wide range of gram-positive and gram-negative bacteria (including strains that have acquired resistance to beta-lactam antibiotics due to the production of b-lactamases).

Indications

Treatment of infectious and inflammatory diseases caused by drug-sensitive microorganisms: – upper respiratory tract and ENT infections (including acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsillitis, pharyngitis);-lower respiratory tract infections (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);– urinary tract infections;– gynecological infections;– skin and soft tissue infections;– bone and joint infections;– biliary tract infections (cholecystitis, cholangitis);– odontogenic infections.

Use during pregnancy and lactation

Amoxicillin and clavulanic acid pass in small amounts into breast milk.

Amoxiclav can be used during pregnancy in cases where the expected benefit to the mother exceeds the potential risk to the fetus.

Contraindications

-cholestatic jaundice or liver dysfunction caused by taking amoxicillin/clavulanic acid in the anamnesis; – hypersensitivity to amoxicillin, clavulanic acid or penicillins. With caution, the drug should be prescribed for a history of allergic reactions to cephalosporins and pseudomembranous colitis, liver failure, severe renal dysfunction.

Due to the fact that a large number of patients with infectious mononucleosis and lymphocytic leukemia treated with ampicillin, the appearance of erythematous rash was observed, the use of ampicillin antibiotics in such patients is not recommended.

Side effects

From the digestive system: possible loss of appetite, nausea, vomiting, diarrhea; rarely-transient increase in the activity of liver enzymes (ALT, AST), liver function disorders; in isolated cases – cholestatic jaundice, hepatitis, pseudomembranous colitis.

Allergic reactions: erythematous rash, pruritus, urticaria; rarely-erythema multiforme, angioedema, anaphylactic shock; in rare cases-exfoliative dermatitis, Stevens-Johnson syndrome.

Other: rarely-development of superinfection, candidiasis.

Interaction

With the simultaneous use of Amoxiclav and indirect anticoagulants, an increase in prothrombin time is noted. Therefore, this combination is prescribed with caution.

Concomitant use of Amoxiclav with allopurinol increases the risk of side effects such as exanthema. When used concomitantly, Amoxiclav increases the toxicity of methotrexate.

The combination of Amoxicillin with rifampicin is antagonistic (there is a mutual weakening of the antibacterial effect).

Amoxiclav should not be used simultaneously with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to the possible decrease in the effectiveness of Amoxiclav.

When used concomitantly, Amoxiclav reduces the effectiveness of oral contraceptives.

How to take, course of use and dosage

Amoxiclav Kviktab tablets are taken orally, previously dissolved in half a glass of water (at least 30 ml) and thoroughly mixed. It is possible to hold the tablets in your mouth until they are completely dissolved, and then swallow. In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken at the beginning of a meal.

Adults and children over 12 years (with body weight >40 kg) with mild or moderate during infection appoint 1 tablet (625 mg) every 12 hours, in case of severe infections and respiratory tract infections – 1 tablets (625 mg) every 8 hours or 1 tablet (1000 mg) every 12 h

The duration of treatment is up to 14 days.

If treatment begins with parenteral use of the drug, it is possible to continue therapy with oral Amoxiclav Kviktab tablets.

In accordance with the severity of renal functional disorders, the dose of the drug should be reduced and/or the interval of use should be increased. Moderate renal insufficiency (creatinine clearance 10-30 ml / min) prescribe 1 tablet (625 mg) every 12 hours. In severe renal insufficiency (CC

Overdose

Symptoms: abdominal pain, diarrhea, vomiting; possibly also agitation, insomnia, dizziness; in some cases – convulsions.

Treatment: in case of recent use of the drug (less than 4 hours), gastric lavage should be performed and activated charcoal should be prescribed to reduce the absorption of the drug; if necessary, symptomatic therapy should be performed. Hemodialysis is effective.

Special instructions

During the course of treatment, the function of hematopoiesis, liver and kidneys should be monitored.

In patients with severe renal impairment, adequate adjustment of the dosage regimen or an increase in the intervals between dosing is required.

In order to reduce the risk of adverse reactions from the gastrointestinal tract, the drug should be taken with meals.

When using Amoxiclav, a false positive reaction is possible when determining the level of glucose in the urine when using Benedict’s reagent or Felling’s solution (it is recommended to use enzymatic reactions with glucose oxidase).

Concomitant use with disulfiram should be avoided.

Form of production

Dispersible tablets

Storage conditions

In a place protected from moisture, at a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Amoxicillin, Clavulanic Acid

Conditions of release from pharmacies

By prescription

Dosage form

soluble tablets

Description

For adults as prescribed by a doctor, Children over 12 years of age, Children as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Tonsillitis, Osteomyelitis, Bronchitis, Sore Throat, Laryngitis, Cholecystitis, Periodontitis, Sinusitis, Urinary Tract Infections, Pneumonia, Otitis media