Antareit Chewable tablets 800/40mg, 12pcs

Composition

1 chewable tablet with a dosage of 800 mg+40 mg contains:

Active ingredients: magaldrate-800.00 mg, simethicone (in terms of dimethylpolysiloxane) – 61.54 (40.00) mg.

Excipients: ethylcellulose-36.00 mg, macrogol-4000-140.00 mg, sorbitol-513.18 mg, sucralose-4.32 mg, aspartame-5.00 mg, caramel flavor-12.96 mg, colloidal silicon dioxide-9.00 mg, glyceryl dibegenate-18.00 mg.

Tablet weight-1600,00 mg

Pharmacological action

A combined drug, the action of which is determined by the properties of its constituent components. It has an antacid, adsorbent, enveloping, carminative effect.

Magaldrat

Magaldrate (aluminum magnesium hydroxide sulfate) neutralizes free hydrochloric acid in the stomach without causing secondary hypersecretion of gastric juice. Due to an increase in the pH, when it is taken, the peptic activity of gastric juice decreases. It has an adsorbing and enveloping effect, which reduces the impact of damaging factors on the gastric mucosa, binds bile acids.

Simethicon

Simethicone changes the surface tension of gas bubbles formed in the stomach contents and intestinal mucus, and causes their destruction. The gases released in this case can be absorbed by the cells of the intestinal walls, or removed due to peristalsis. Simethicone removes foam in a purely physical way, does not enter into chemical reactions, and is pharmacologically inert.

Pharmacokinetics

Magaldrat

The absorption of aluminum and magnesium ions in the blood is low. With normal kidney function, the concentration of aluminum and magnesium in the blood does not change. In patients with chronic renal failure, the content of aluminum and magnesium in the blood may increase to toxic values as a result of impaired excretion.

Simethicon

Simethicone due to pharmacological and chemical inertia after oral use is not absorbed into organs and tissues. After passing through the gastrointestinal tract (GIT), it is excreted unchanged by the intestines.

Indications

Symptoms associated with increased acidity of gastric juice and reflux esophagitis: heartburn, belching “sour taste”, pain in the stomach (appear irregularly), a feeling of fullness or heaviness in the epigastric region, flatulence, dyspepsia (including those caused by errors in diet, medication, alcohol abuse, coffee, nicotine).

Use during pregnancy and lactation

No controlled clinical studies have been conducted with the use of Antareit in pregnant women, but no teratogenic effect or effect has been detected in preclinical studies. Due to the lack of clinical experience, the use of the drug during pregnancy is possible only if the benefit of its use for the mother exceeds the potential risk to the fetus.

You should avoid prescribing the drug during pregnancy in large doses and for a long time.

Breast-feeding should not be discontinued while taking Antareit.

Contraindications

Hypersensitivity to the components of the drug; severe renal failure; hypophosphatemia; fructose intolerance (due to the presence of sorbitol in the drug); children under 12 years of age.

With caution: in case of renal insufficiency (with prolonged use, an increase in the content of magnesium and aluminum in the blood plasma may occur); in case of Alzheimer’s disease; in case of low phosphate content in food (risk of developing phosphate insufficiency).

Side effects

Allergic reactions, nausea, vomiting, impaired taste, constipation, diarrhea.

With prolonged use in high doses – hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminemia, encephalopathy, nephrocalcinosis, impaired renal function. In patients with concomitant renal insufficiency – a feeling of thirst, a decrease in blood pressure, hyporeflexia.

Interaction

Antara reduces and slows down the absorption of digoxin, Indometacin, salicylates, chlorpromazine, phenytoin, N₂-of histamine antagonists, beta-blockers, diflunisal, isoniazid, antibiotics, tetracycline, quinolone (ciprofloxacin, norfloxacin, ofloxacin, enoxacin, grepafloxacin, etc. ), azithromycin, cefpodoxime, pivampicillin, rifampicin, anticoagulants, barbiturates, Fexofenadine, dipyridamole, zalcitabine, bile acid – chenodeoxycholic and ursodeauxiholeva, the penicillamine, oral iron, and lithium, quinidine, of lansoprazole, mexiletine, ketoconazole.

M-holinoblokatory, slowing down the emptying of the stomach, enhance and lengthen the effect of the drug.

How to take, course of use and dosage

Inside. Tablets should be thoroughly chewed or kept in the mouth until completely absorbed.

Adults and adolescents over 12 years of age: if the doctor does not recommend otherwise,1-2 tablets are taken a short time after a meal. If necessary, you can repeat the drug after 2 hours.

The maximum daily dose for tablets is 400 mg+20 mg-16 tablets; for tablets

800 mg+40 mg-8 tablets.

Overdose

Symptoms: with prolonged use of high doses, kidney stones may form, constipation, drowsiness, hypermagnesemia. There may also be signs of metabolic alkalosis: lability of mood, a feeling of numbness or pain in the muscles, nervousness and rapid fatigue, unpleasant taste sensations.

Treatment: it is necessary to take measures for rapid elimination of the drug: flush the stomach, induce vomiting, take activated charcoal.

Description

Biconvex tablets of white or almost white color, octagonal shape, with beveled edges, with an apple-shaped engraving and the letter “g” on one side. Dark spots are allowed.

Special instructions

When using the drug Antareit and other medications at the same time, you should adhere to the interval of at least 1-2 hours. When taking it for a long time, it is necessary to ensure sufficient intake of phosphorus with food. With mild to moderate renal impairment, it is necessary to regularly monitor the content of aluminum, calcium, and phosphates in blood plasma. The drug contains sorbitol, which is contraindicated in congenital fructose intolerance.

Form of production

Chewable tablets 800 mg+40 mg. 6 tablets in a blister of PVC / A 1 foil.

Storage conditions

Store in a dry place protected from light at a temperature not exceeding 25 °C.

Keep out of reach of children.

Shelf

life is 3 years.

Do not use after the expiration date indicated on the package.

Active ingredient

Magaldrat, simeticon

Dosage form

tablets for resorption

Description

Nursing mothers as prescribed by a doctor, For adults, Pregnant women as prescribed by a doctor, Children over 12 years of age

Indications

Reflux Esophagitis, Flatulence, Heartburn