Ascorbic acid, ampoules 5%, 2ml, 10pcs – Biosintez

Composition

Active ingredient: ascorbic acid 50 mg. Auxiliary substances: sodium bicarbonate (sodium bicarbonate) 23.85 mg or 47.7 mg, sodium sulfite (sodium sulphate) 2 mg or 2 mg, water for injection, saturated with carbon dioxide up to 1 ml

Pharmacological action

Vitamin C. Ascorbic acid is essential for the formation of intracellular collagen, and is required to strengthen the structure of teeth, bones, and capillary walls.

It participates in redox reactions, tyrosine metabolism, folic acid conversion to folinic acid, carbohydrate metabolism, lipid and protein synthesis, iron metabolism, cellular respiration processes, activates the synthesis of steroid hormones. Reduces the need for vitamins_B1, _B2, A, E, folic acid, pantothenic acid, increases the body’s resistance to infections; improves the absorption of iron, contributing to its deposition in a reduced form. It has antioxidant properties.

When used intravaginally, ascorbic acid reduces the pH of the vagina, inhibits bacterial growth and helps restore and maintain normal pH values and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).

Indications

It is used for preventive and curative purposes in all clinical situations associated with the need for additional use of vitamin C. It is prescribed for the prevention and treatment of scurvy, with bleeding (nasal, pulmonary, uterine, caused by radiation sickness), hemorrhagic diathesis, with various intoxications and infectious diseases, nephropathy of pregnant women, Addison’s disease, with an overdose of anticoagulants, bone fractures and sluggish wounds, various dystrophies, with increased mental stress and increased physical labor.

Contraindications

Hypersensitivity, with prolonged use in large doses (more than 500 mg) – diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency. With caution sideroblastic anemia, urolithiasis. Use during pregnancy and lactation During pregnancy and lactation is used only if the intended benefit to the mother exceeds the potential risk to the fetus and child. The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to the high doses of ascorbic acid that a pregnant woman takes, and then the newborn may develop a “withdrawal”syndrome. The minimum daily requirement during lactation is 80 mg. A mother’s diet containing an adequate amount of ascorbic acid is sufficient to prevent its deficiency in an infant. Theoretically, there is a danger for the child when the mother uses high doses of ascorbic acid (it is recommended that the nursing mother does not exceed the daily requirement for ascorbic acid).

Side effects

From the central nervous system: with rapid intravenous use – dizziness, fatigue, with prolonged use of large doses (more than 1 g) – headache, increased excitability of the central nervous system, insomnia. From the urinary system: moderate pollakiuria (with a dose of more than 600 mg/day), with prolonged use of large doses-hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys. From the cardiovascular system: with prolonged use of high doses-a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, the development of microangiopathies). Allergic reactions: allergic reactions up to the development of anaphylactic shock. Laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glucosuria. Local reactions: soreness at the site of intramuscular injection. Other: with prolonged use of large doses (more than 1 g) – inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria), with intravenous use-the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.

Interaction

Pharmacologically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafzillin, benzylpenicillin, warfarin. Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day, it increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives). Reduces the effectiveness of heparin and indirect anticoagulants. When used concomitantly with acetylsalicylic acid, the urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases. Increases the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. Quinoline-type drugs, calcium supplements, salicylates, and glucocorticosteroids deplete ascorbic acid reserves with prolonged use. When used concomitantly, it reduces the chronotropic effect of isoprenaline. When used for a long time or in high doses, it may interfere with the interaction of disulfiram and ethanol. In high doses, it increases the excretion of mexiletine by the kidneys. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

How to take, course of use and dosage

Apply as prescribed by a doctor. Ascorbic acid is prescribed orally (after meals), intramuscularly or intravenously. For preventive purposes, adults are prescribed 0.05 g-0.1 g per day; during pregnancy, in the postpartum period, and in the case of a low content of vitamin C in the milk of nursing women,0.3 g per day is prescribed for 10-15 days, after which 0.1 g per day is prophylactically administered during the entire lactation period. Children are prescribed prophylactically 0.025 g 2-3 times a day. Therapeutic doses for adults are taken orally-0.05-0.1 g 3-5 times a day; for children-0.05-0.1 g 2-3 times a day. Therapeutic doses for adults with parenteral use is 1-3 ml of 5% solution (2-6 ml of 2.5% solution) per day. Children are prescribed parenterally 1-2 ml of a 5% solution (2-4 ml of a 2.5% solution) per day. The course of treatment depends on the nature and course of the disease.

Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia. Treatment: symptomatic, forced diuresis.

Special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenal glands and blood pressure. High doses of ascorbic acid increase the excretion of oxalates, contributing to the formation of kidney stones. Newborns whose mothers have taken high doses of ascorbic acid and adults who have taken high doses may experience rebound scurvy. With prolonged use of large doses, the function of the pancreatic insular apparatus may be inhibited, so it should be regularly monitored during treatment. In patients with high iron content in the body, ascorbic acid should be used in minimal doses. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (the content of glucose in the blood and urine, bilirubin, the activity of” liver ” transaminases and lactate dehydrogenase). Influence on the ability to drive motor vehicles and control mechanisms During treatment, care should be taken when driving vehicles and engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Storage conditions

In a dark place at a temperature not exceeding 15°C

Shelf

life is 1 year.

Active ingredient

Ascorbic acid

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Indications

Wounds, Stress, Bleeding, Colds, Varicose Veins, Hypovitaminosis, Malnutrition, Infectious Diseases, Intense Physical activity, Flu and Cold prevention, Flu, Bone Fractures