Ascorbic acid, sachets, 2.5g

Product description

dietary supplement is a medicinal product

Composition

Sugar (from sugar beet), ascorbic acid.

Pharmacological action

Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food.

Increases the activity of amide enzymes involved in the processing of oxytocin, ADH and cholicystokinin.

Participates in steroidogenesis in the adrenal glands.

Reduces iron trivalent to iron divalent in the intestine, promoting its absorption.

The main role in tissues is the participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.

Indications

Prevention and treatment of vitamin C hypo-and beriberi.

Conditions of increased need for ascorbic acid: unbalanced nutrition, increased mental and physical exertion, recovery period after serious illnesses, febrile state against the background of acute respiratory infections, acute respiratory viral infections, pregnancy (multiple, against the background of nicotine or drug addiction).

Use during pregnancy and lactation

During pregnancy, you should consult a doctor before using the drug. The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. The minimum daily requirement during breastfeeding is 80 mg. A mother’s diet containing an adequate amount of ascorbic acid is sufficient to prevent vitamin C deficiency in an children (it is recommended that the nursing mother does not exceed the maximum monthly requirement for ascorbic acid). It should be borne in mind that the fetus can adapt to the high doses of ascorbic acid that a pregnant woman takes and then the newborn may develop a “withdrawal”syndrome.

Contraindications

Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, abdominal pain of a spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.

If any side effects occur, you should stop taking the drug and consult a doctor.

Treatment: symptomatic, forced diuresis.

Side effects

From the central nervous system (CNS): headache, fatigue, with prolonged use of large doses – increased excitability of the central nervous system, sleep disorders, insomnia.

From the digestive system: irritation of the gastrointestinal mucosa, with prolonged use of large doses-hyperacid gastritis, ulceration of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).

From the urinary system: when used in high doses – hyperoxalaturia and the formation of urinary stones from calcium oxalate, moderate pollakiuria (when taking a dose of more than 600 mg / day), with prolonged use of large doses-damage to the glomerular apparatus of the kidneys.

From the cardiovascular system: thrombosis, when used in high doses – increased blood pressure, the development of microangiopathies, myocardial dystrophy. With prolonged use of high doses-a decrease in capillary permeability (possible deterioration of tissue trophism, hypercoagulation).

Allergic reactions: skin rash, hyperemia of the skin, rarely-anaphylactic shock.

Laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Other: a feeling of heat, with prolonged use of large doses-sodium (Na+) and fluid retention, impaired metabolism of zinc (Zn2+), copper (Cu2+).

Interaction

Increases the concentration of benzylpenicillin and tetracyclines in the blood, at a dose of 1 g/day increases the bioavailability of ethinyl estradiol. Improves intestinal absorption of iron preparations (converts trivalent iron to bivalent), may increase iron excretion when used concomitantly with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption. When used concomitantly with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by about 30%.

Increases the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Preparations of the quinoline series (fluoroquinolones, etc. ), calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the reserves of ascorbic acid.

When used concomitantly, it reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, the disulfiram-ethanol interaction may be disrupted.

In high doses, it increases the renal excretion of mexiletine. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Reduces the effectiveness of heparin and indirect anticoagulants.

How to take, course of use and dosage

Inside, after eating. The powder is used to prepare drinks-2.5 g of ascorbic acid powder (the contents of one sachet) per 2.5 liters of water. The solution is taken freshly prepared, in accordance with the dosages suggested below. For dosing, it is recommended to use a medical measuring cup.

For prevention: adults 50 mg-100 mg (50 ml – 100 ml) per day, children from 5 years of age 50 mg (50 ml) per day.

For treatment: adults 50 mg-100 mg (50 ml – 100 ml) 3-5 times a day, children from 5 years of age 50 mg (50 ml) – 100 mg (100 ml) 2-3 times a day.

During pregnancy and lactation,300 mg (300 ml) per day for 10-15 days, then 100 mg (100 ml) per day.

For adults: maximum single dose-200 mg, daily-1 g, for children: maximum single dose-100 mg, daily-500 mg.

Note: The medical measuring cup is not included.

Overdose

Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, abdominal pain of a spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.

If any side effects occur, you should stop taking the drug and consult a doctor.

Treatment: symptomatic, forced diuresis.

Special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of glucocorticoid hormones, it is necessary to monitor the function of the adrenal glands and blood pressure. With prolonged use of large doses, the function of the pancreatic insular apparatus may be inhibited, so it should be regularly monitored during treatment. In patients with high iron content in the body, ascorbic acid should be used in minimal doses. Prescribing ascorbic acid to patients with… rapidly proliferating and intensively metastasizing tumors can worsen the course of the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, lactate dehydrogenase). High doses of ascorbic acid increase the excretion of oxalates, contributing to the formation of kidney stones. Rebound scurvy may occur in newborns whose mothers have taken high doses of ascorbic acid and adults who have taken high doses.

Active ingredient

Ascorbic acid

Dosage form

powder for oral use

Indications

Flu, Hypovitaminosis, Intense Exercise, Bone Fractures, Infectious Diseases, Active growth period, Recovery Period, Malnutrition, Stress, Flu and cold prevention, Cold