Ascorbinka powder 2.5g sachets, 1pc

Product description

dietary supplements. It is not a medicinal product

Composition

Active ingredient: ascorbic acid 2,5 g

Pharmacological action

Pharmacotherapeutic group: vitamin. ATX Code: A11GA01 Pharmacological Properties Pharmacodynamics  Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food Pharmacological effects: in amounts significantly exceeding the daily requirement (90 mg), it has almost no effect, except for the rapid elimination of symptoms of hypo-and beriberi (scurvy). Physiological functions: it is a cofactor of some hydroxylation and amidation reactions-it transfers electrons to enzymes, providing them with a reducing equivalent. It participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethylysine (during the synthesis of graphite), oxidation of folic acid to folic acid, drug metabolism in liver microsomes, and hydroxylation of dopamine with the formation of norepinephrine. Increases the activity of amide enzymes involved in the processing of oxytocin, antidiuretic hormone and cholicystokinin. Participates in steroidogenesis in the adrenal glands. Reduces ferric iron ions to ferric bivalent ions in the intestine, promoting its absorption. The main role in tissues is the participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and endothelium of intercellular capillaries. In low doses (150-250 mg/day orally), it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter. Pharmacokinetics It is absorbed in the gastrointestinal tract (mainly in the jejunum). With an increase in the dose to 200 mg, up to 140 mg is absorbed (70%); with a further increase in the dose, absorption decreases (50-20%). Binding to plasma proteins is 25%. Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum 12, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestines. The concentration of ascorbic acid in plasma is normally approximately 10-20 mcg / ml, reserves in the body — about 1.5 g when taking the daily recommended doses and 2.5 g when taking 200 mg / day. The time to reach the maximum concentration (TCmax) after oral use is 4 hours. It easily penetrates into white blood cells, platelets, and then into all tissues; the highest concentration is achieved in glandular organs, white blood cells, liver and lens of the eye; it penetrates through the placenta. The concentration of ascorbic acid in white blood cells and platelets is higher than in red blood cells and in plasma. In deficient states, the concentration in white blood cells decreases later and more slowly and is considered as a better criterion for assessing the deficit than the concentration in plasma. It is mainly metabolized in the liver to deoxyascorbic acid and then to oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, breast milk in unchanged form and in the form of metabolites. When high doses are administered, the rate of elimination increases dramatically. Smoking and drinking ethanol accelerate the breakdown of ascorbic acid (conversion to inactive metabolites), dramatically reducing the body’s reserves. It is excreted during hemodialysis.

Indications

Prevention and treatment of hypo-and avitaminosis of vitamin C. As an auxiliary agent: hemorrhagic diathesis, nasal, uterine, pulmonary and other bleeding, including those caused by radiation sickness, overdose of anticoagulants, diseases of the gastrointestinal tract accompanied by impaired absorption of vitamin C, injuries. Conditions that are accompanied by an increased need for vitamin C: increased physical and mental stress, pregnancy and lactation, recovery from long-term illnesses.

Recommendations for use

The contents of the package (500 mg) are diluted in ½ cup (100-150 ml) of warm water, stir thoroughly and take adults immediately after cooking 1 time a day; do not store in diluted form. The duration of admission is 10 days. If necessary, you can repeat the procedure.

Contraindications

Individual intolerance to the components, pregnancy, breast-feeding. It is recommended to consult your doctor before use.

Side effects

From the central nervous system (CNS): headache, fatigue, with prolonged use of large doses (more than 1000 mg) — increased excitability of the central nervous system, sleep disorders.

From the digestive system: irritation of the gastrointestinal mucosa, with prolonged use of large doses-nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa.

From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).

From the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg / day), with prolonged use of large doses — hyperoxaluria, formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys.

From the cardiovascular system: with prolonged use of high doses-a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, the development of microangiopathies).

Allergic reactions: skin rash, anaphylactic shock.

Laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glucosuria.

Other: hypervitaminosis, a feeling of heat, with prolonged use of large doses — sodium and fluid retention, impaired metabolism of zinc, copper.

If any side effects occur, you should stop taking the drug and consult a doctor.

Interaction

Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day, it increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives). Improves intestinal absorption of iron preparations (converts trivalent iron to bivalent); may increase iron excretion when used concomitantly with deferoxamine.

Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption. When used concomitantly with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by about 30%. Increases the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Medicinal products of the quinoline series (fluoroquinolones, etc. ), calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the reserves of ascorbic acid. When used concomitantly, it reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, the interaction of disulfiram and ethanol may be disrupted. In high doses, it increases the renal excretion of mexiletine.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

Reduces the effectiveness of heparin and indirect anticoagulants.

Overdose

Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, abdominal pain of a spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia. Treatment: symptomatic, forced diuresis.

Description

It is used as a dietary supplement-a source of vitamin C.

Special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of glucocorticoid hormones, it is necessary to monitor kidney function and blood pressure. With prolonged use of large doses, the function of the pancreatic insular apparatus may be inhibited, so it should be regularly monitored during treatment. In patients with high iron content in the body, ascorbic acid should be used in minimal doses. Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood and urine glucose, bilirubin, transaminase activity, LDH). High doses of ascorbic acid increase the excretion of oxalates, contributing to the formation of kidney stones. Influence on the ability to drive motor vehicles and manage mechanisms Ascorbic acid does not affect the ability to drive vehicles and perform work that requires an increased rate of psychomotor reactions.

Conditions of release from pharmacies

Over-the-counter