Ascorutin (C + Rutin) pills Renewal, 50pcs

Product description

dietary supplements. It is not a medicinal product

Composition

Active ingredients: Ascorbic acid-50.0 mg of rutoside trihydrate-54.4 mg (based on rutoside (rutin)) – 50.0 mgsupport substances: sucrose-181.3 mg potato starch-38.7 mgpovidone K 30-3.5 mgcalcium stearate-2.1 mg

Pharmacological action

Pharmacotherapeutic group: vitamin. ATX Code: C 05 CA 51 Pharmacological properties

Pharmacodynamics

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and increases the body’s resistance.

Rutoside (a derivative of rutin) eliminates increased capillary permeability, strengthens the vascular wall, reducing its swelling and inflammation. It has an angiaggregant effect, which helps to improve microcirculation.

Pharmacokinetics

Ascorbic acid

Suction

It is absorbed in the gastrointestinal tract (GIT), mainly in the jejunum. With an increase in the dose to 200 mg, up to 140 mg is absorbed (70%), with a further increase in the dose, absorption decreases (50-20%). Binding to plasma proteins is 25%. Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum 12, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbate in the intestines.

Distribution

The concentration of ascorbic acid in plasma is normally approximately 10-20 mcg / ml, reserves in the body – about 1.5 g when taking the daily recommended doses and 2.5 g when taking 200 mg / day. TSmax (half-life) after oral use – 4 hours.

Easily penetrates into white blood cells, platelets, and then into all tissues; the highest concentration is achieved in glandular organs, white blood cells, liver and lens of the eye; deposited in the posterior pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates through the placenta. The concentration of ascorbic acid in white blood cells and platelets is higher than in red blood cells and in plasma. In deficient states, the concentration in white blood cells decreases later and more slowly and is considered as a better criterion for assessing the deficit than the concentration in plasma.

Metabolism

It is mainly metabolized in the liver to deoxyascorbic acid and then to oxaloacetic acid and diketogulonic acid.

Deduction

It is excreted by the kidneys, through the intestines, with sweat, breast milk in the form of unchanged ascorbate and metabolites. When high doses are administered, the rate of elimination increases dramatically. Smoking and drinking ethanol accelerate the breakdown of ascorbic acid (conversion to inactive metabolites), dramatically reducing the body’s reserves. It is excreted during hemodialysis.

Rutoside

The time of maximum concentration in blood plasma after oral use is 1-9 hours. It is mainly excreted in the bile and to a lesser extent by the kidneys. The elimination half-life is 10-25 hours.

Indications

Hypo-and avitaminosis of ascorbic acid and rutoside. As part of complex therapy for varicose veins, trophic disorders and skin ulcers, with chronic venous insufficiency; with hemorrhagic diathesis.

Contraindications

• Increased individual sensitivity to the components of the drug;
• congenital fructose intolerance, glucose-galactose malabsorption, sucrose/isomaltase deficiency; 
• pregnancy (I trimester);
• children under 18 years of age.

With caution

Conditions associated with blood hypercoagulation and a tendency to thrombosis, thrombophlebitis, diabetes mellitus.

If you have one of these diseases, be sure to consult your doctor before taking the drug.

Use during pregnancy and lactation Due to the content of rutin in the preparation, it should not be used in the first trimester of pregnancy.

When using the drug during pregnancy (II-III trimesters) and during breastfeeding, it is necessary to observe the dosage and duration of the course of use prescribed by the doctor.

Side effects

Possible allergic reactions (skin rash), dyspeptic disorders, headache.

It is important to report the development of adverse reactions in order to ensure continuous monitoring of the benefit-risk ratio of the drug.

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor. Health professionals report adverse drug reactions through national adverse reaction reporting systems.

Interaction

Ascorbic acid increases the absorption of penicillin and iron drugs; reduces the clinical effect of heparin and indirect anticoagulants, which requires dose adjustment when used simultaneously. If you are using the above or other medications (including over-the-counter medications), please consult your doctor before using Ascorutin.

How to take, course of use and dosage

Inside. Take 1 tablet 2-3 times a day during or after meals. The course of treatment is 2-3 weeks. If there is no improvement after treatment, or if the symptoms worsen or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Overdose

Symptoms:  excessive use of the drug can cause nausea, vomiting, diarrhea, and headache. Treatment:  symptomatic, forced diuresis. In case of overdose with the drug, you should immediately consult a doctor.

Description

It is recommended as a dietary supplement, an additional source of vitamin C, and a source of rutin.

Vitamins are active chemical compounds of organic nature that participate in the metabolism and are necessary for the body to maintain its vital functions.

Vitamin C (ascorbic acid) strengthens the immune system, increases resistance to viral and bacterial infections, helps reduce the severity of colds and reduce their duration. It stimulates the production of liver enzymes that help remove toxins from the body in a polluted environment. Also a vitamin C is necessary for the synthesis of collagen, a protein that forms the basis of connective tissue and provides strength to the skin, tendons, ligaments, and blood vessels. It has a positive effect on the functioning of the body’s cardiovascular system, stimulates blood clotting, increases the absorption of iron and folic acid. Participating in the functioning of the adrenal glands and regulating the production of cortisol (stress hormone), vitamin C helps prevent stress and depression, and restore emotional stability.

Rutin, together with ascorbic acid, participates in redox processes, thereby stimulating energy metabolism. Due to its antioxidant properties, rutin protects cells from the damaging effects of free radicals, inhibiting the aging process in them, and also protects ascorbic acid from excessive oxidation, preserving its biological activity. Rutin is one of the most effective venotonics. Its action is aimed at increasing the smooth muscle tone of the vascular walls, maintaining their elasticity, and normalizing blood circulation in the affected areas. By reducing the permeability of the vascular walls, rutin helps reduce puffiness and avoids its re-formation.

The human body is not able to independently produce its own ascorbic acid and rutin, so its normal functioning requires a daily intake of vitamins with food or in the form of special supplements.

Regular intake of ascorbic acid and routine contributes to:

• strengthening the vascular wall, reducing its swelling and inflammation;

• improving microcirculation (due to antiplatelet action);

• eliminating increased capillary permeability;

• accelerating redox processes;

• increasing the body’s resistance;

• accelerating tissue regeneration processes;

• and normalizing blood clotting.

Special instructions

Patients with diabetes should take into account that one tablet of the drug contains about 0.2 g of carbohydrates (0.017 XE).

When using the drug independently, it is recommended not to exceed the maximum time and recommended doses.

If there is no reduction or if the symptoms of the disease become more severe, it is recommended to consult a doctor.

Influence on the ability to drive vehicles and mechanisms

The use of the drug does not affect the ability to perform potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms).

Storage conditions

At a temperature not exceeding 25 °C in the pack. Keep out of reach of children.

Shelf

life is 3 years.

Conditions of release from pharmacies

Without a prescription

Dosage form

Tablets