Composition
Active ingredient: azithromycin (in the form of dihydrate) 500 mg
Pharmacological action
An antibiotic of the macrolide group, it is a representative of azalides. Inhibits RNA-dependent protein synthesis in sensitive microorganisms.
Active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes /group A/); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.
Azithromycin is also active against Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, and Treponema pallidum.
It is also active against Toxoplasma gondii.
It is rapidly absorbed from the gastrointestinal tract. Food intake reduces the absorption of azithromycin. Cmax in plasma is reached in 2-3 hours.
It is rapidly distributed in tissues and body fluids. 35% of azithromycin is metabolized in the liver by demethylation. More than 59% is excreted unchanged in the bile, and about 4.5% is excreted unchanged in the urine.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to azithromycin, including bronchitis, pneumonia, skin and soft tissue infections, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non-gonorrheal urethritis and / or cervicitis, Lyme disease (borreliosis).
Contraindications
Hypersensitivity to azithromycin and other macrolide antibiotics.
Side effects
From the digestive system: Â when taken orally – diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less – dyspepsia, flatulence, vomiting, melena, cholestatic jaundice, increased activity of “liver” transaminases; in addition, in children – constipation, anorexia, gastritis; candidiasis of the oral mucosa (with intravenous use). From the cardiovascular system: palpitations, chest pain (1% or less).
Nervous system disorders: dizziness, headache, vertigo, drowsiness; in children-headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disorders (1% or less).
From the genitourinary system: vaginal candidiasis, nephritis (1% or less).
Allergic reactions: rash, photosensitivity, angioedema.
Interaction
Antacids (aluminum and magnesium-containing ones), ethanol, and food slow and reduce absorption. When warfarin and azithromycin were co-administered (in normal doses), no changes in prothrombin time were detected, however, given that the interaction of macrolides and warfarin may increase the anticoagulation effect, patients should carefully monitor prothrombin time.
Digoxin: increased digoxin concentration. Ergotamine and dihydroergotamine: increased toxic effects (vasospasm, dysesthesia). Triazolam: reduced clearance and increased pharmacological action of triazolan. Slows down the elimination and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine phenytoin, phenytoin, oral hypoglycemic agents, theophylline and other xanthine derivatives) – due to the inhibition of microsomal oxidation in hepatocytes by azithromycin).
Lincosamines weaken the effectiveness, tetracycline and chloramphenicol-increase Pharmacologically incompatible with heparin.
How to take, course of use and dosage
Inside,1 hour before or 2 hours after meals 1 time a day.
For adults
For upper and lower respiratory tract infections-0.5 g / day for 1 dose for 3 days (course dose-1.5 g).
For infections of the skin and soft tissues – 1 g / day on the first day for 1 reception, then 0.5 g / day daily from day 2 to day 5 (the course dose is 3 g).
Acute infections of the genitourinary organs (uncomplicated urethritis or cervicitis)-once 1 g.
In Lyme disease (borreliosis) for the treatment of stage I (erythema migrans) – 1 g on the first day and 0.5 g daily from day 2 to 5 (course dose – 3 g).
In gastric and duodenal ulcers associated with Helicobacter pylori – 1 g / day for 3 days as part of combined anti-helicobacter therapy.
Children are prescribed at the rate of 10 mg / kg once a day for 3 days or on the first day – 10 mg / kg, then 4 days-5-10 mg / kg / day for 3 days (the course dose is 30 mg/kg).
Special instructions
If a missed dose is missed, the missed dose should be taken as early as possible, and subsequent doses should be taken at 24 – hour intervals.
It is necessary to observe a break of 2 hours with simultaneous use of antacids. The safety of prescribing azithromycin (intravenously, as well as in the form of capsules and tablets) in children and adolescents under 16 years of age has not been definitively established (it is possible to use it as an oral suspension in children from 6 months and older).
After discontinuation of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy under the supervision of a doctor.
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding 25°C.
Shelf life
2 years
Active ingredient
Azithromycin
Conditions of release from pharmacies
By prescription
Dosage form
Tablets
Description
For pregnant women as prescribed by a doctor, For adults, For adults as prescribed by a doctor, For children over 12 years of age
Indications
Pharyngitis, Tonsillitis, Otitis media, Sore throat, Respiratory tract infections, Pneumonia, Infectious diseases, Skin infections, Bronchitis, Urethritis
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