Bacteriophage coliprophyte solution for oral, external and external use, 100ml

Composition

The solution contains:

Active ingredient:  

a mixture of sterile phagolysates of bacteria Proteus vulgaris, Proteus mirabilis and enteropathogenic Escherichia coli of various serogroups 100 ml.

Auxiliary substances:

8-hydroxyquinoline sulfate monohydrate 0.0001 g / ml.

Pharmacological action

The drug causes specific lysis of the bacteria Proteus vulgaris, Proteus mirabilis, Escherichia coli.

Indications

Treatment and prevention of purulent-inflammatory and enteral diseases, dysbiosis caused by Proteus and enteropathogenic Escherichia coli bacteria as part of complex therapy:

• Diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy).
• Surgical infections (wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hydroadenitis, panaritia, paraproctitis, mastitis, bursitis, osteomyelitis).
• Urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis).
• Enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbiosis.
• Generalized septic diseases.
• Purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc. ).
• Other diseases caused by proteus and E. coli.

An important condition for effective phage therapy is a preliminary determination of the phage sensitivity of the pathogen.

Use during pregnancy and lactation

The use of this medicinal product during pregnancy and lactation is possible in the presence of infections caused by phage-sensitive bacterial strains (on the recommendation of a doctor).

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Not installed.

Interaction

The drug can be used in combination with other medications, including antibiotics.

How to take, course of use and dosage

The drug is used for oral use, rectal use, applications, irrigation, injection into the cavities of wounds, vagina, uterus, nose, sinuses and drained cavities.

Recommended dosage of the drug:

• Patient age 0-6 months – 5 doses per 1 dose when the drug is administered orally (ml) – 5-10 doses per 1 dose when the drug is administered in an enema (ml).
• Patient age 6-12 months – 10 doses per 1 dose when the drug is administered orally (ml) – 10-20 doses per 1 dose when the drug is administered in an enema (ml).
• Age of the patient from 1 year to 3 years – 15 doses per 1 dose when the drug is administered orally (ml) – 20-30 doses per 1 dose when the drug is administered in an enema (ml).
• Age of the patient from 3 to 8 years – 15-20 doses per 1 dose when the drug is administered orally (ml) – 30-40 doses per 1 dose when the drug is administered in an enema (ml).
• Age of the patient from 8 years and older – 20-30 doses per 1 dose when the drug is administered orally (ml) – 40-50 doses per 1 dose when the drug is administered in an enema (ml).

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally for 7-20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds prior to the use of the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.

Depending on the focus of infection, the bacteriophage is used:

Use of bacteriophage in children (up to 6 months).

In sepsis, enterocolitis of newborns, including premature infants, the bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation, the drug can be used by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (by mouth) use of the drug is possible. The course of treatment is 5-15 days. With a recurrent course of the disease, it is possible to conduct repeated courses of treatment. In order to prevent sepsis and enterocolitis in case of intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, infected wounds, the drug is used in the form of applications twice a day (a gauze cloth is moistened with bacteriophage and applied to the umbilical wound or the affected area of the skin).

Special instructions

In case of turbidity, do not use the drug!

Due to the content of a nutrient medium in the preparation, in which bacteria from the environment can develop, causing turbidity of the drug, it is necessary to observe the following rules when opening the bottle: :

• Wash your hands thoroughly.
• Treat the cap with an alcohol-containing solution.
• Remove the cap without opening the stopper.
• Do not place the cork inside on the table or other objects.
• Do not leave the bottle open.
• Store the opened bottle only in the refrigerator.

When using small doses (2-8 drops), the drug should be selected with a sterile syringe in a volume of 0.5-1 ml.

The drug from the opened bottle, subject to the storage conditions, the above rules and the absence of turbidity, can be used during the entire shelf life.

Influence on the ability to drive motor vehicles and manage mechanisms

Absent.

Form of production

Solution for oral use, topical and external use.

Storage conditions

The drug is stored in accordance with SP 3.3.2.1248-03 in a dry place protected from light and inaccessible to children at a temperature of 2 to 8°C.

Shelf

life is 2 years.

Active ingredient

Coliprotein bacteriophage

Dosage form

solution for oral use

Description

For adults as prescribed by a doctor, for children as prescribed by a doctor

Indications

Laryngitis, Pharyngitis, Sore Throat, Osteomyelitis, Respiratory tract Infections, Otitis media, Boils, Burns, Colitis, Purulent wounds, Intestinal Infections, Cholecystitis, Dysbiosis, Bronchitis, Urethritis