Betahistine pills 24mg, 20pcs

Composition

1 tablet contains:

Active ingredient:

betahistine dihydrochloride 24 mg;

excipients:

microcrystalline cellulose,

lactose monohydrate,

citric acid monohydrate,

colloidal silicon dioxide,

talc,

calcium stearate.

Pharmacological action

Pharmacodynamics

Betahistine acts mainly on histamine H1-and H3-receptors of the inner ear and vestibular nuclei of the central nervous system. By direct agonistic (stimulating) action on the H1-receptors of the inner ear vessels, as well as indirectly through the action on the H3-receptors, it improves microcirculation and capillary permeability, normalizes endolymph pressure in the labyrinth and cochlea. At the same time, betahistine increases blood flow in the basilar artery.

It has a pronounced central effect, being an inhibitor of H3 – receptors of the vestibular nerve nuclei. Improves conduction in neurons of the vestibular nuclei at the level of the brain stem.

Reduces the frequency and intensity of dizziness, reduces tinnitus, improves hearing when it decreases.

A stable therapeutic effect occurs after 14 days.

Pharmacokinetics

Absorbed completely after oral use, the connection with plasma proteins is low. The time to reach the maximum concentration in blood plasma is 3 hours. It is almost completely excreted by the kidneys as a metabolite (2-pyridylacetic acid) within 24 hours.

The elimination half-life is 3-4 hours.

Indications

Treatment of Meniere’s syndrome, characterized by dizziness (accompanied by nausea and vomiting), hearing loss and tinnitus.

Symptomatic treatment of vestibular vertigo (vertigo).

Use during pregnancy and lactation

There is insufficient data to assess the possibility of using the drug during pregnancy and lactation. In this regard, it is not recommended to take the drug Betahistine during pregnancy.

If taking the drug is necessary during lactation, breastfeeding should be discontinued.

Contraindications

• Hypersensitivity to the components of the drug Betahistine,
• pheochromocytoma,
• pregnancy,
• lactation,
• childhood;
• lactase deficiency,
• lactose intolerance,
• glucose-galactose malabsorption.

With caution: peptic ulcer of the stomach or duodenum 12 (in the anamnesis), bronchial asthma.

Side effects

From the digestive system: nausea, dyspepsia.

Nervous system disorders: headache.

Allergic reactions: hypersensitivity, including anaphylactic reactions.

From the digestive system: vomiting, abdominal pain, bloating.

Skin disorders: angioedema, urticaria, pruritus, rash.

Interaction

Betahistine is a histamine analog, and the interaction of betahistine with histamine receptor blockers can theoretically affect the effectiveness of one of these drugs.

How to take, course of use and dosage

Inside, with a meal,1 tablet of Betahistine 2 times a day.

The dose of the drug and the duration of use are selected individually, depending on the patient’s response to the therapy.

Improvement of the condition is noted already at the beginning of the course of therapy, a stable therapeutic effect occurs after 2-3 weeks of treatment.

Overdose

Symptoms: nausea, abdominal pain, drowsiness (when taken at a dose of up to 640 mg); convulsions, cardiopulmonary complications (when taken at a dose of more than 640 mg or in combination with other medications).

Treatment: gastric lavage, taking activated charcoal, symptomatic therapy.

Special instructions

The therapeutic effect in some cases increases within a few months from the start of treatment.

Influence on the ability to drive vehicles and mechanisms

It is possible to reduce the speed of psychomotor reactions, which reduces the ability to drive vehicles and work with precise mechanisms.

Form of production

Tablets

Storage conditions

Store in a dry place protected from light at a temperature not exceeding 25 °C.

Shelf

life is 2 years.

Active ingredient

Betahistine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Meniere’s disease, Cerebrovascular Accident