Betaxolol pills 20mg, 30pcs

Composition

Active ingredient:

betaxolol hydrochloride-20 mg;

excipients, including shell composition:

lactose monohydrate,

sodium starch glycolate,

colloidal anhydrous silicon dioxide,

magnesium stearate,

microcrystalline cellulose,

polyvinyl alcohol,

titanium dioxide E 171,

talc,

macrogol / PEG 3350,

lecithin (soy).

Pharmacological action

Cardioselective beta-1-adrenoblocker without internal sympathomimetic activity. It has a weak membrane-stabilizing activity.

It has a hypotensive effect associated with a decrease in the minute volume of the heart and a decrease in sympathetic stimulation of peripheral vessels.

When used in therapeutic doses, it does not have a cardiodepressive effect, does not affect glucose metabolism, does not reduce the bronchodilating effect of beta-adrenomimetics, and does not cause a delay in sodium ions in the body. Valid for a long time.

When applied topically in the form of eye drops, it lowers increased intraocular pressure. The resorptive effect is insignificant.

Indications

For systemic use: arterial hypertension.

For topical use in ophthalmology: chronic open-angle glaucoma, increased intraocular pressure, condition after laser trabeculoplasty.

Contraindications

Cardiogenic shock, severe forms of chronic heart failure, grade II and III AV block, SSR, sinoatrial block, sinus bradycardia, severe peripheral circulatory disorders, hypersensitivity to betaxolol.

Side effects

From the cardiovascular system:  at the beginning of treatment – AV block, sinus bradycardia, hypotension, heart failure, Raynaud’s syndrome.

From the digestive system:  rarely-abdominal pain, nausea, vomiting.

From the central nervous system and peripheral nervous system:  at the beginning of treatment – asthenia, paresthesia of the extremities, sleep disorders, depression, drowsiness, dizziness.

Respiratory system disorders:  rarely-bronchospasm.

Allergic reactions:  rarely-psoriasis-like skin manifestations.

Local reactions:  when applied in the form of eye drops immediately after instillation, short – term discomfort in the eyes, sometimes lacrimation, is possible; rarely-a decrease in corneal sensitivity, erythema, itching, spotty coloration of the cornea, keratitis, anisocoria, photophobia.

Interaction

When used concomitantly with adrenomimetics, xanthine derivatives, the effectiveness of betaxolol decreases.

When used concomitantly with antacids and antidiarrheal agents, it is possible to reduce the absorption of beta-blockers.

When used concomitantly with antihypertensive agents, the antihypertensive effect increases.

With the simultaneous use of halogen-containing agents for inhalation anesthesia, it is possible to increase the negative inotropic effect.

With the simultaneous use of non-depolarizing muscle relaxants, their duration of action may increase.

Concomitant use of NSAIDs and corticosteroids reduces the antihypertensive effect of betaxolol.

With simultaneous use of cardiac glycosides, bradycardia may increase.

With the simultaneous use of tricyclic antidepressants (imipramine), blood pressure decreases, and there is a risk of developing orthostatic hypotension.

Concomitant use of amiodarone, verapamil, diltiazem, beta-blockers for topical use in glaucoma may increase the negative inotropic effect and conduction disturbances.

Concomitant use of lidocaine increases the concentration of lidocaine in the blood plasma.

When used concomitantly with drugs that deplete catecholamine reserves (including reserpine), the hypotensive effect and bradycardia may increase.

Concomitant use with sulfasalazine increases the concentration of betaxolol in the blood plasma.

How to take, course of use and dosage

For systemic use when taken orally-20 mg 1 time/day.

For patients on permanent hemodialysis or peritoneal dialysis, the initial dose is 10 mg/day; the time of taking betaxolol is set regardless of the mode of dialysis sessions.

For topical use in ophthalmology – 1 drop 2 times / day in the affected eye.

During the first month, therapy is carried out under the control of the level of intraocular pressure, in the future, the frequency of measurement of intraocular pressure is determined individually.

In the case of using betaxolol after previous treatment with another similar drug, the dosage regimen is set individually.

Special instructions

It is not recommended for use in bronchial asthma, chronic bronchitis with bronchial obstructive syndrome.

It is used with caution in patients with diabetes mellitus, suspected thyrotoxicosis, with a history of bronchial hyperreactivity, in patients with grade I AV block, Raynaud’s syndrome, pheochromocytoma.

When used orally in hepatic insufficiency, as well as in renal insufficiency (creatinine clearance less than 20 ml / min) There is no need to adjust the dosage regimen, but regular clinical follow-up is recommended during the first few days of treatment.

In the first days of treatment, the possibility of developing symptoms of heart failure in predisposed patients should be taken into account. Withdrawal of betaxolol should be carried out gradually, especially in patients suffering from CHD, angina pectoris.

Betaxolol does not affect the pupil size, so in case of angle-closure glaucoma, the drug should be used only in combination with myotics. When transferring a patient to betaxolol after treatment with several anti-glaucoma drugs, the latter are canceled gradually, for a period of at least 1 week per drug.

With the simultaneous use of betaxolol in the form of eye drops and beta-blockers inside, it is possible to develop additive effects both from intraocular pressure and manifestations of the systemic action of beta-blockers.

Beta-blockers, including betaxolol, should be discontinued before elective surgery.

When applying betaxolol topically, contact lenses should not be worn.

It is not recommended to use betaxolol in children.

Influence on the ability to drive motor vehicles and manage mechanisms

It is used with caution in patients whose activity requires increased attention and rapid psychomotor reactions.

Form of production

Pills.

Active ingredient

Betaxolol

Conditions of release from pharmacies

By prescription

Dosage form

Tablets