Bisoprolol pills 5mg, 30pcs

Composition

1 tablet contains bisoprolol (in the form of fumarate) 5 mg

Pharmacological action

Bisoprolol is a selective beta-1-adrenoblocker without internal sympathomimetic activity, does not have membrane-stabilizing activity.

Bisoprolol reduces plasma renin activity, reduces myocardial oxygen demand, reduces heart rate (at rest and during exercise) and cardiac output, while the stroke volume does not significantly decrease.

Inhibits AV conduction. It has antianginal and antihypertensive effects. In high doses (200 mg or more) it can cause blockade of beta-2-adrenergic receptors mainly in the bronchi and in vascular smooth muscles.

Indications

Arterial hypertension, prevention of angina attacks.

Contraindications

Chronic heart failure II B – III stage, cardiogenic shock, AV-block II and III degree, SSSU, sinoatrial block, bradycardia, hypotension (systolic pressure less than 90 mm Hg. St. ) the tendency to bronchospasm (bronchial asthma and other diseases with bronchial obstruction syndrome), severe peripheral circulatory disorders; simultaneous reception of MAO inhibitors (except MAO inhibitors of type B), hypersensitivity to bisoprolol and other beta-blockers; pregnancy and lactation.

Side effects

From the central nervous system and peripheral nervous system: weakness, fatigue, dizziness, headache, sleep disorders, mental disorders (depression, rarely-hallucinations), a feeling of cold and paresthesia in the extremities. From the cardiovascular system: orthostatic hypotension, bradycardia, impaired AV conduction, the appearance of symptoms of heart failure, exacerbation of intermittent claudication and the main clinical symptoms in Raynaud’s syndrome. From the side of the organ of vision: decreased secretion of lacrimal fluid, conjunctivitis. From the digestive system: diarrhea, constipation, nausea, abdominal pain. Musculoskeletal disorders: muscle weakness, muscle cramps.

Interaction

Allergens used for immunotherapy or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients receiving bisoprolol.

Iodine-containing radiopaque drugs for intravenous use increase the risk of anaphylactic reactions. Phenytoin with intravenous use, drugs for inhaled general anesthesia (hydrocarbon derivatives) increase the severity of cardiodepressive effects and the likelihood of lowering blood pressure.

Changes the effectiveness of insulin and oral hypoglycemic drugs, masks the symptoms of developing hypoglycemia (tachycardia, increased blood pressure).

The antihypertensive effect is weakened by NSAIDs (Na + delay and blockade of Pg synthesis by the kidneys), corticosteroids and estrogens (Na+delay). Cardiac glycosides, methyldopa, reserpine and guanfacine, BMCC (verapamil, diltiazem), amiodarone, etc. Antiarrhythmic drugs increase the risk of developing or worsening bradycardia, AV block, cardiac arrest, and heart failure. Nifedipine can lead to a significant decrease in blood pressure. Diuretics, clonidine, sympatholytics, hydralazine and other antihypertensive drugs can lead to an excessive decrease in blood pressure.

It prolongs the action of non-depolarizing muscle relaxants and the anticoagulant effect of coumarins.

Tri-and tetracyclic antidepressants, antipsychotic drugs (neuroleptics), ethanol, sedatives and sleeping pills increase CNS depression. Concomitant use with MAO inhibitors is not recommended due to a significant increase in the antihypertensive effect, a break in treatment between taking MAO inhibitors and bisoprolol should be at least 14 days.

Non-hydrogenated ergot alkaloids increase the risk of developing peripheral circulatory disorders. Ergotamine increases the risk of developing peripheral circulatory disorders; rifampicin shortens T1 / 2.

How to take, course of use and dosage

Individual approach.

For oral use, the daily dose of Bisoprolol is 2.5-10 mg, the frequency of use is 1 time/day.

The maximum daily dose is 10 mg.

Overdose

Symptoms:

arrhythmia, ventricular extrasystole, severe bradycardia, AV block, decreased blood pressure, CHF, cyanosis of the fingernails or palms, difficulty breathing, bronchospasm, dizziness, fainting, convulsions.

Treatment:

gastric lavage and use of adsorbent drugs; symptomatic therapy:  if AV block develops, intravenous use of 1-2 mg of atropine, epinephrine or a temporary pacemaker is recommended; with ventricular extrasystole – lidocaine (class Ia drugs are not used); with a decrease in blood pressure-the patient should be in the Trendelenburg position; if there are no signs of pulmonary edema, – intravenous plasma-substituting solutions, if ineffective-use of epinephrine, dopamine, dobutamine (to maintain chronotropic and inotropic effects and eliminate a pronounced decrease in blood pressure); with HF-cardiac glycosides, diuretics, glucagon; for convulsions – iv diazepam; in case of bronchospasm – beta-2-adrenostimulants by inhalation.

Special instructions

Use with caution for psoriasis and indications of psoriasis in the family history, diabetes mellitus in the decompensation phase, with a predisposition to allergic reactions.

With pheochromocytoma, the use of bisoprolol is possible only after taking alpha-blockers. To avoid sudden withdrawal of bisoprolol, the course of treatment should be completed slowly with a gradual decrease in the dose.

Storage conditions

Store in a dry place protected from light, out of reach of children, at a temperature not exceeding 20 °C.

Active ingredient

Bisoprolol

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Hypertension, Arrhythmia, Heart Failure