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What is Blincito?

Blincito (blinatumomab) is a prescription drug used to treat some forms of acute lymphoblastic leukemia (ALL). This type of immunotherapy targets and attaches to cancer cells, alerting the immune system to attack the malignancy. Blincito specifically targets a protein called CD19, which is found on the surface of B-cell leukemia cells.

Blincito Composition

Each Blincito box contains one vial of Blincito and one vial of IV Solution Stabilizer. The single-dose vial of Blincito contains 35 mcg blinatumomab, lysine hydrochloride, polysorbate 80, trehalose dihydrate, sodium hydroxide (to adjust pH to 7.0), and citric acid monohydrate. The single-dose vial of IV Solution Stabilizer contains citric acid monohydrate, lysine hydrochloride, polysorbate 80, sodium hydroxide (to adjust pH to 7.0), and water for injection.

Benefits and Effects of Blincito

Blincito has shown significant responses in patients with ALL who have relapsed or are resistant to other treatments. It is also used to treat patients with ALL who have minimal residual disease (MRD) following a complete remission on chemotherapy. This indicates that cancer cells may still be present in the body after chemotherapy.

Uses of Blincito

• First or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 for CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL) in adult and pediatric patients one month and older.
• Refractory or relapse in adult and pediatric patients one month and older with CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL).
• Consolidation phase of multiphase chemotherapy for adult and pediatric patients one month and older with CD19-positive Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia (ALL).

How to Use Blincito

Blincito is administered through a continuous intravenous (IV) infusion, meaning the drug is delivered into your body through a vein. The infusion typically lasts four weeks, followed by a two-week break from therapy. Blincito dosage is administered in cycles.

Dosage and Administration

The dosage of Blincito depends on the patients weight and the type of ALL being treated. Patients weighing 45 kg or more are typically prescribed a dosage of 28 mcg daily. For patients weighing less than 45 kg, the dosage is calculated based on their body surface area (BSA).

Blincito can be infused over a period of seven days, 24 hours, or 48 hours. The treating healthcare provider should determine the infusion length based on the frequency of infusion bag changes and the patients weight.

Side Effects of Blincito

Blincito can cause serious side effects, including:

• Cytokine release syndrome (CRS)
• Infusion reactions
• Neurological complications

Symptoms of CRS include fever, chills, headache, nausea, vomiting, stomach/abdominal discomfort, shortness of breath (dyspnea), skin rash, weakness, or low blood pressure. Other drugs, foods, colors, dyes, or preservatives can cause unexpected or adverse reactions to blinatumomab or other medications, or lead to seizures, confusion, difficulty speaking, loss of balance, or other neurological toxicity symptoms.

Contraindications

Patients who are hypersensitive to blinatumomab or any of the formulation excipients should not use Blincito.

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