Composition
1 tablet contains: active ingredient: desloratadine – 5 mg; auxiliary components: croscarmellose sodium, aspartame, citric acid monohydrate, mannitol, potassium polacrylate, magnesium stearate, red iron oxide dye, microcrystalline cellulose, tutti-frutti flavor (maltodextrin, modified starch E 1450, propylene glycol E 1520, flavoring agents).
Pharmacological action
Histamine H1-receptor blocker (long-acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and eases the course of allergic reactions. It has anti-allergic, antipruritic and anti-exudative effects. Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm. It has practically no sedative effect and when taken at a dose of 7.5 mg does not affect the speed of psychomotor reactions. In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs at comparable doses (taking into account the concentration of desloratadine).
Indications
Seasonal allergic rhinitis, chronic idiopathic urticaria.
Recommendations for use
Adults and adolescents aged 12 years and older are prescribed orally, regardless of food intake, at a dose of 5 mg/day.
Children aged 1 to 5 years – 1.25 mg 1 time/day, aged 6 to 11 years-2.5 mg 1 time/day.
Contraindications
Phenylketonuria, pregnancy, lactation, children under 1 year of age, hypersensitivity to desloratadine.
Side effects
Nervous system disorders: headache, hallucinations, psychomotor hyperreactivity, seizures.
From the digestive system: dry mouth, hepatitis.
Other services: photosensitivity, myalgia, shortness of breath, feeling tired.
Interaction
The study of interaction with ketoconazole and erythromycin did not reveal clinically significant changes.
Does not affect the effects of ethanol.
Special instructions
Desloratadine should be used with caution in patients with severe renal insufficiency.
Influence on the ability to drive motor vehicles and manage mechanisms
There were no adverse effects on driving or complex technical devices.
Active ingredient
Desloratadine
Dosage form
solution for oral use
Description
For adults, Children over 12 years of age
Indications
Conjunctivitis, Allergy, Dermatitis, Pollinosis, Urticaria, Runny Nose
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