Butadion, pills 150mg, 20pcs

Composition

Phenylbutazone 150 mg

Pharmacological action

Pharmacogroup:

NSAIDs.

Pharmaceutical action:

NSAIDs have anti-inflammatory, analgesic and antipyretic effects associated with the suppression of COX and COX-2 activity, which regulate the synthesis of PG. It has an uricosuric effect.

Pharmacokinetics:

 When taken orally, absorption is high; bioavailability is 85-90%, decreases with prolonged use. TCmax – 1-2 hours. Binding to plasma proteins is more than 95%.

It is metabolized in the liver to form 2 major metabolites. T1 / 2 – 18-24 hours Excreted by the kidneys 70% (5% unchanged), through the gastrointestinal tract-30% in the form of metabolites, in significant quantities is excreted in breast milk.

Indications

Burns of the first and second degree of a small area, including sunburn; dermatitis, skin inflammation at the site of intramuscular or intravenous injections, insect bites; inflammation of hemorrhoids and superficial thrombophlebitis; traumatic soft tissue injuries; Ankylosing spondylitis, erythema nodosum, chorea minor, etc.

Butadion is used to treat joint diseases of various etiologies — acute and subacute stages of articular rheumatism (inferior, however, to salicylates in heart defects complicated by endomyocarditis and circulatory disorders), acute, subacute and chronic rheumatoid polyarthritis, non-specific infectious polyarthritis, gout, thrombophlebitis, osteoarthritis, tendinitis, tendovaginitis.

The beneficial effect of Butadione is noted in bronchial asthma, neuralgia, neuritis, and myalgia.

Contraindications

Hypersensitivity; complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to ASA or other NSAIDs (including in the anamnesis); erosive and ulcerative lesions of the gastrointestinal tract in the acute stage (peptic ulcer of the stomach and duodenum, ulcerative colitis, peptic ulcer), bone marrow depression, decompensated CHF or pulmonary heart failure, severe hepatic and/or renal insufficiency (creatinine clearance less than 30 ml/min), the period after coronary artery bypass grafting; progressive kidney disease, active liver disease, confirmed hyperkalemia, pregnancy (third trimester), active gastrointestinal bleeding, inflammatory bowel diseases. With caution. Hyperbilirubinemia, bronchial asthma, CHF, edema, arterial hypertension, hemophilia, hypocoagulation, liver failure, CRF, hearing loss, vestibular apparatus pathology, blood diseases, diabetes mellitus, SLE, polymyalgia rheumatoid, transient arteritis, ulcerative diseases of the gastrointestinal tract, stomatitis, coronary heart disease, cerebrovascular diseases, dyslipidemia/hyperlipidemia, heart diseases peripheral artery disease, smoking, CRF (creatinine clearance 30-60 ml/min), a history of gastrointestinal ulcers, H. pylori infection, old age, long-term use of NSAIDs, alcoholism, severe somatic diseases, concomitant use of oral corticosteroids (including prednisone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective inhibitors reuptake of serotonin (including citalopram, fluoxetine, paroxetine, sertraline), pregnancy, lactation.

Side effects

From the digestive system: dyspepsia, NSAIDs-gastropathy, abdominal pain, nausea, vomiting, heartburn, diarrhea or constipation; with prolonged use in large doses – ulceration of the gastrointestinal mucosa, aphthous stomatitis, glossitis, erosive esophagitis, bleeding (gastrointestinal, gingival, hemorrhoidal), liver dysfunction.

From the cardiovascular system: increased blood pressure, tachycardia.

Nervous system disorders: headache, dizziness, drowsiness, depression, agitation.

Sensory disorders: hearing loss, tinnitus.

Hematopoietic disorders: agranulocytosis, leukopenia, anemia, thrombocytopenia.

Allergic reactions: skin rash, pruritus, urticaria, bronchospasm, edematous syndrome, angioedema.

Other: increased sweating, uterine bleeding.

Interaction

Increases the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, side effects of corticosteroids and MCS, estrogens, morphine, PASC, penicillin, hypoglycemic effect of sulfonylurea derivatives.

Reduces the effectiveness of uricosuric, antihypertensive drugs and diuretics.

Increases the concentration of Li+ and methotrexate in the blood. Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

Antacids and colestyramine reduce absorption.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

How to take, course of use and dosage

Inside,0.2-0.4 g during or after meals 3-4 times a day.

Children aged from 6 months – 0.01-0.1 g (depending on age) 3-4 times a day. The duration of therapy is 2-5 weeks or more.

Overdose

Symptoms: cyanosis of the fingertips, lips, body skin, dizziness, headache, increased or decreased blood pressure, hyperventilation of the lungs, blurred consciousness, in children-myoclonic convulsions, nausea, vomiting, abdominal pain, hemorrhages, impaired liver and kidney function. Treatment: gastric lavage, use of activated charcoal, symptomatic therapy aimed at maintaining vital body functions. Forced diuresis and hemodialysis are ineffective.

Special instructions

During treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver and kidneys. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

During treatment, you should refrain from engaging in potentially dangerous activities that require increased attention and speed of mental and motor reactions. To reduce the risk of gastrointestinal adverse events, the minimum effective dose should be used in the shortest possible course.

Form of production

Pills.

Active ingredient

Phenylbutazone

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults, Children over 15 years of age, Adults as prescribed by a doctor, Pregnant women only in the second trimester as prescribed by a doctor

Indications

Rheumatoid Arthritis, Trigeminal Neuralgia, Bruises, Lumbago, Osteoarthritis, Osteoarthritis and Arthritis, Dislocations and Sprains, Sciatica