Composition
Rifampicin 150 mg
Pharmacological action
Rifampiin is a broad-spectrum antibiotic. It is active against mycobacterium tuberculosis and leprosy, acts on gram-positive (especially staphylococci) and Gram-negative (meningococci, gonococci) cocci, and is less active against Gram-negative bacteria.
Rifampiin is well absorbed from the gastrointestinal tract. The maximum concentration in the blood is reached in 2-2′ / 2 hours after ingestion.
With intravenous drip use, the maximum concentration of rifampicin is observed by the end of the infusion (infusion). At the therapeutic level, the concentration of the drug when taken orally and intravenously is maintained for 8-12 hours, for highly sensitive pathogens – for 24 hours.
Rifampicin penetrates well into body tissues and fluids and is found in therapeutic concentrations in pleural exudate (protein-rich fluid accumulating between the membranes surrounding the lungs), sputum, the contents of cavities (cavities in the lungs formed due to tissue necrosis), and bone tissue. The highest concentration of the drug is created in the tissues of the liver and kidneys. It is excreted in bile and urine.
Resistance to rifampicin develops rapidly. No cross-resistance with other antibiotics is observed (with the exception of rifamiin).
Indications
Tuberculosis (including tuberculosis meningitis) in combination therapy. MAS infection. Infectious and inflammatory diseases caused by rifampicin-sensitive pathogens (including osteomyelitis, pneumonia, pyelonephritis, leprosy; meningococcal carrier).
Contraindications
Hypersensitivity, including to other drugs of the rifamycin group, impaired liver and kidney function, infectious hepatitis transmitted less than 1 year ago, jaundice, including mechanical.
Intravenous use: cardiopulmonary insufficiency of II-III degrees, phlebitis, children’s age.
Side effects
From the digestive system: nausea, vomiting, diarrhea, decreased appetite; increased levels of hepatic transaminases, bilirubin in blood plasma, pseudomembranous colitis, hepatitis.
Allergic reactions: urticaria, angioedema, bronchospasm, flu-like syndrome.
From the hematopoietic system: rarely-thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, hemolytic anemia.
From the central nervous system: headache, ataxia, visual impairment.
From the urinary system: necrosis of the renal tubules, interstitial nephritis, acute renal failure.
Endocrine system disorders: menstrual cycle disorders.
Other services: red-brown staining of urine, feces, saliva, sputum, sweat, tears.
Interaction
Due to the induction of microsomal liver enzymes (isoenzymes CYP2C9, CYP3A4), rifampicin accelerates the metabolism of theophylline, oral anticoagulants, oral hypoglycemic drugs, hormonal contraceptives, digitalis preparations, verapamil, phenytoin, quinidine, corticosteroids, chloramphenicol, antifungal drugs, which leads to a decrease in their plasma concentrations and, accordingly, to a decrease in their action.
How to take, course of use and dosage
When taken orally for adults and children-10 mg / kg 1 time/day or 15 mg / kg 2-3 times a week. Take on an empty stomach, the duration of treatment is set individually.
IV adults-600 mg 1 time/day or 10 mg / kg 2-3 times a week, children-10-20 mg / kg 1 time/day or 2-3 times a week.
It is possible to introduce 125-250 mg into the pathological focus (by inhalation, intracavitary use, as well as introduction into the focus of skin damage).
Maximum doses: when taken orally for adults, the daily dose is 1.2 g, for children 600 mg, with intravenous use for adults and children-600 mg.
Special instructions
Use with caution for liver diseases, exhaustion.
In the treatment of non-tuberculosis infections, microbial resistance may develop rapidly; this process can be prevented if rifampicin is combined with other chemotherapeutic agents. Rifampicin is better tolerated with daily use than with intermittent treatment. If it is necessary to resume treatment with rifampicin after a break, then you should start with a dose of 75 mg / day, gradually increasing it by 75 mg / day until the desired dose is reached. At the same time, renal function should be monitored; additional use of corticosteroids is possible.
With prolonged use of rifampicin, systematic monitoring of the blood picture and liver function is indicated; a sample loaded with bromosulfalein should not be used, since rifampicin competitively inhibits its excretion.
PASC preparations containing bentonite (aluminum hydrosilicate) should be prescribed no earlier than 4 hours after taking rifampicin.
In newborns and premature infants, rifampicin is used only in cases of extreme necessity.
Available on prescription.
Form of production
Solution for infusions
Storage conditions
Store in a dry place, protected from light, at a temperature not exceeding 25 °C.
Shelf life
2 years
Active ingredient
Rifampicin
Conditions of release from pharmacies
By prescription
Dosage form
solution for infusions
Description
Children as prescribed by a doctor, Adults as prescribed by a doctor
Indications
From tuberculosis
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Side effects of Rifampicin, ampoules 150mg, 10pcs.
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