Sedalgin Plus, pills 20pcs

Composition

1 tablet contains:

active ingredients:

metamizole sodium 500 mg,

caffeine 50 mg,

thiamine hydrochloride 38.75 mg;

excipients:

microcrystalline cellulose 45.75 mg,

wheat starch 11.00 mg,

gelatin 4.00 mg,

colloidal silicon dioxide 2.50 mg,

talc 12.00 mg,

magnesium stearate 6.00 mg

Pharmacological action

Sedalgin Plus is a combined drug that has analgesic, antipyretic and anti-inflammatory effects.

Metamizole sodium is a pyrazolone derivative and has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis due to cyclooxygenase inhibition.

Caffeine-has a stimulating effect on the central nervous system (CNS), mainly on the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness and fatigue.

Caffeine increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect.

Thiamine (vitamin B) is involved in the metabolism, and contributes to the improvement of neuro-reflex conduction.

Indications

• headache (including Migraine),
• toothache,
• neuralgia,
• muscle
• pain, joint pain,
• root syndrome,
• menstrual pain,
• fever syndrome in infectious and inflammatory diseases.

Contraindications

• severe hepatic or renal insufficiency,
• bronchospasm,
• diseases of the blood system,
• insomnia,
• uncontrolled arterial hypertension,
• severe atherosclerosis,
• increased intraocular pressure.

Side effects

• allergic reactions,
• nausea,
• vomiting,
• insomnia,
• dizziness,
• thrombocytopenia,
• leukopenia,
• agranulocytosis,
• hemolytic anemia,
• purpura,
• palpitations.

Interaction

Concomitant use of metamizole sodium (analgin) with other non-narcotic analgesics, non-steroidal anti-inflammatory drugs may lead to a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

Barbiturates, phenylbutazone (butadione) and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium. Simultaneous use of metamizole sodium with cyclosporine reduces the concentration of the latter in the blood.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

How to take, course of use and dosage

Inside after a meal,1 tablet 2-3 times in the morning.

The maximum single dose for adults and adolescents from 16 years of age is 2 tablets, the maximum daily dose is 6 tablets for no more than 1-2 days.

Children aged 12 to 16 years – half or one tablet 2-3 times a day, the maximum daily dose is 4 tablets.

The duration of admission is no more than 5 days when prescribed as an analgesic and 3 days as an antipyretic.

If the symptoms of the disease persist or worsen, you should consult a doctor.

Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a doctor.

Overdose

Symptoms:  nausea and vomiting sometimes with blood, stomach pain, mental and motor agitation, tachycardia, cardiac arrhythmias, possible decrease or increase in diuresis, convulsions, anxiety, confusion, delirium, dehydration, hyperthermia, headache, increased tactile or pain sensitivity, tremor or muscle twitching; tinnitus, epileptic seizures (in acute overdose – tonic-clonic).

Treatment:  you should seek immediate medical attention. The victim should be given gastric lavage, adsorbents (for example, activated charcoal), and laxatives.

If necessary, symptomatic treatment is performed (for hemorrhagic gastritis – use of antacid medications and gastric lavage with an icy 0.9% sodium chloride solution; maintenance of lung ventilation and oxygenation; for epileptic seizures-intravenous diazepam, phenobarbital or phenytoin; maintaining fluid and salt balance).

Special instructions

Excessive consumption of caffeinated products (tea, coffee) during treatment may cause symptoms of overdose.

Use with caution and under medical supervision in patients with impaired liver or kidney function.

Concomitant use of the drug with alcoholic beverages is not recommended. Patients with atopic bronchial asthma, pollinosis, have an increased risk of developing hypersensitivity reactions.

Influence on the ability to drive vehicles and work with mechanisms

Caution should be exercised when driving vehicles and working with mechanisms that require increased concentration of attention and speed of psychomotor reactions, since dizziness may develop when taking the drug.

Form of production

Pills.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of reach of children!

Shelf

life is 2 years.

Active ingredient

Metamizole Sodium, Caffeine, Thiamine

Dosage form

Tablets

Description

Children over 12 years old, For adults

Indications

From myositis, From sciatica, Cold, Flu, From Sciatica, Neuralgia, From migraines, Myalgia, From lumbago, Fever, From osteoarthritis and arthritis, From neuritis