Composition
Active ingredients:
metamizole sodium 2,5 g,
pitofenone hydrochloride 10 mg,
fenpiverinium bromide 100 mcg
Pharmacological action
Spasgan is a combined drug that belongs to the group of aldehydes and antispasmodics. The composition of the drug includes: non-narcotic analgesic metamizole sodium (analgin), myotropic antispasmodic agent pitofenone hydrochloride and cholinoblocking agent fenpiverinium bromide.
Metamizole is a derivative of pyrozolone. It has analgesic, antipyretic, and weak anti-inflammatory effects.
Pitofenone, like papaverine, has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation.
Fenpiverinium has an additional relaxing effect on smooth muscles due to its holinoblocking effect.
The combination of the three components of the drug leads to a mutual strengthening of their pharmacological action.
Indications
- pain of various origins
- spasms of internal organs (renal colic, biliary colic)
- postoperative pain. spasms of the brain vessels.
Use during pregnancy and lactation
Spasgan is contraindicated in pregnant women, nursing mothers, and children under 3 months of age.
Contraindications
- agranulocytosis
- ischemic heart
- disease glaucoma
- prostate adenoma
- severe hepatic-renal insufficiency
- hypersensitivity to the components of the drug.
Side effects
- a decrease in the number of white blood cells in the blood
- a drop in blood pressure
- impaired renal function
- allergic reactions.
Interaction
Concomitant use of Spasgan with other non-narcotic analgesics can lead to a mutual increase in toxic effects.
Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.
Barbiturates, phenylbutazone, and other inducers of microsomal liver enzymes weaken the effect of metamizole. Concomitant use with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers enhance the analgesic effect of Spasgan.
If you need to use these and other medications at the same time, you should consult your doctor.
How to take, course of use and dosage
For colic, the drug is administered intravenously 1 ampoule (5 ml) slowly for 5-8 minutes.
Repeated use is possible in 6-8 hours.
The drug can be administered intramuscularly, but its effect occurs after 20-30 minutes.
Overdose
Symptoms: Â vomiting, decreased blood pressure, drowsiness, confusion, nausea, vomiting, epigastric pain, liver and kidney function disorders, convulsions.
Treatment: Â gastric lavage, use of activated charcoal, symptomatic therapy.
Special instructions
In patients with bronchial asthma, taking the drug can provoke the development of an attack.
Form of production
Solution for injection.
Storage conditions
In a dry place, at a temperature not exceeding 25 °C
Shelf life
3 years
Active ingredient
Metamizole sodium, Pitofenone, Fenpiverinium bromide
Conditions of release from pharmacies
By prescription
Dosage form
solution for injection and infusion
Description
For adults, Children as prescribed by a doctor, Pregnant women only in the second trimester as prescribed by a doctor
Indications
From dyskinesia of the biliary tract, From gastrointestinal spasms
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Side effects of Spasgan solution for intravenous and intramuscular injection 5ml ampoules, 5pcs.
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