Calcium chloride, ampoules 10%, 10ml, 10pcs – Biofabrika

Composition

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1 ml of solution for intravenous use contains:

Active ingredient:  

calcium chloride 100 mg,

auxiliary substance:  

water for injection

Pharmacological action

Calcium chloride is a calcium preparation that makes up for the lack of calcium necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone formation, blood clotting.

Reduces the permeability of cells and the vascular wall, prevents the development of inflammatory reactions, increases the body’s resistance to infections, and can significantly increase phagocytosis (phagocytosis, which decreases after taking sodium chlorine, increases after taking calcium preparations).

When administered intravenously, it stimulates the sympathetic part of the autonomic nervous system, increases the release of epinephrine by the adrenal glands, and has a moderate diuretic effect.

Pharmacokinetics in plasma, about 45% is in a complex with proteins. About 20% is excreted by the kidneys, the remaining amount (80%) is removed with the contents of the intestine.

Indications

• Bleedings various etiology and localization (pulmonary, gastrointestinal, nasal, uterine, etc. );
• allergic disease (serum sickness, kapelnitsa, feverish syndrome, itching, angioedema);
• dystrophic nutritional edema, spasmophilia;
• hypoparathyroidism,
• hypocalcemia,
• increased permeability of blood vessels (hemorrhagic vasculitis, radiation sickness),
• weakness of labor activity,
• poisoning with salts of magnesium, fluoride and oxalic acids: paroxysmal mioplegii (gipercalziemicescoy form).

Contraindications

• Hypersensitivity,
• hypercalcemia,
• atherosclerosis,
• tendency to thrombosis.

Side effects

With intravenous use – a feeling of heat, hyperemia of the skin of the face, bradycardia, with rapid use-ventricular fibrillation of the heart. Local reactions (with intravenous use) – pain and hyperemia along the vein.

Interaction

When combined with thiazide diuretics, it may increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.

How to take, course of use and dosage

Intravenously slowly (6-8 drops / min),5-15 ml of 10% solution, diluting before use in 100-200 ml of 0.9% NaCl solution or 5% dextrose solution.

Special instructions

It can not be administered subcutaneously or intramuscularly, tissue necrosis is possible (high concentrations of calcium chloride, starting from 5%, cause severe irritation of the vascular wall). With intravenous use of calcium chloride, a feeling of heat appears first in the oral cavity, and then throughout the body (previously used to determine the speed of blood flow – the time between the moment of its introduction into the vein and the appearance of a feeling of heat).

Form of production

Solution for intravenous use

Storage conditions

Store in a dry place protected from light at a temperature of 18 to 25 °C. Keep out of reach of children.

Active ingredient

Calcium chloride

Conditions of release from pharmacies

By prescription

Dosage form

infusion solution