Capoten, pills 25mg, 28pcs

Composition

Each Capoten tablet contains: – Captopril 25 mg.

Auxiliary substances:

microcrystalline cellulose,

corn starch,

stearic acid,

lactose.

Pharmacological action

Kapoten is hypotensive.

It is a highly specific competitive ACE inhibitor. Prevents the conversion of angiotensin I to angiotensin II (a powerful vasoconstrictor).

Indications

Arterial hypertension (in the form of monotherapy and in combination with other antihypertensive drugs, especially with thiazide diuretics), chronic heart failure (as part of combination therapy), myocardial infarction (for the treatment of patients with left ventricular dysfunction after a heart attack, in a stable clinical condition), diabetic nephropathy (microalbuminuria more than 30 mg/day) in insulin-dependent diabetes.

Contraindications

Hypersensitivity in the anamnesis (including to other ACE inhibitors), angioedema (hereditary or associated with the use of ACE inhibitors in the anamnesis), severe renal and hepatic dysfunction, hyperkalemia, bilateral renal artery stenosis or stenosis of the artery of a single kidney with progressive azotemia, condition after kidney transplantation, aortic stenosis and similar obstructive changes that hinder blood flow, pregnancy, breastfeeding.

Side effects

From the cardiovascular system:  orthostatic hypotension, tachycardia, peripheral edema.

Respiratory system disorders:  dry cough, bronchospasm, pulmonary edema.

Allergic reactions:  angioedema of the extremities, face, lips, mucous membranes, tongue, pharynx or larynx.

From the side of the water-electrolyte balance:  hyperkalemia (most likely with renal failure), hyponatremia (most often with a salt-free diet and simultaneous use of diuretics.

From the urinary system:  proteinuria, increased urea nitrogen and creatinine levels in blood plasma, acidosis.

From the hematopoietic system:  in rare cases-neutropenia, agranulocytosis, thrombocytopenia and anemia, a positive test for antibodies to the nuclear antigen. In patients with normal renal function (creatinine clearance less than 1.6 mg/dl) in the absence of other complicating factors, neutropenia was observed in 0.02% of cases.

From the digestive system:  reversible and usually self-passing taste disorders, dry mouth, aphthous stomatitis; rarely-abdominal pain, diarrhea, gum hyperplasia, hepatitis, increased levels of hepatic transaminases in blood plasma, hyperbilirubinemia.

Dermatological reactions:  macular-papular rash, usually accompanied by pruritus and in rare cases-an increase in body temperature; hyperemia, vesicular or bullous rashes, erythema (including Stevens-Johnson syndrome), photosensitization.

From the central nervous system and peripheral nervous system:  headache, dizziness, ataxia, paresthesia, drowsiness, visual disturbances.

Interaction

Diuretics, vasodilators, ganglioblockers, and adrenoblockers when used simultaneously enhance the antihypertensive effect of Kapoten.

Indometacin and other NSAIDs, as well as clonidine, may reduce the antihypertensive effect of Kapoten.

Neutropenia and / or Stevens-Johnson syndrome may occur when Capoten is co-administered with allopurinol and procainamide, but cause-and-effect association may occur.

How to take, course of use and dosage

Capoten doses should be selected by your doctor.

Inside, an hour before meals,25-50 mg 2-3 times a day (but not more than 450 mg per day), for children the initial dose is 0.15-0.3 mg/kg (but not more than 6 mg/kg per day).

Overdose

Symptoms:  marked decrease in blood pressure.

Treatment:  use of plasma-substituting drugs and hemodialysis are effective.

Special instructions

Caution should be exercised when using Capoten for collagenosis due to the increased risk of neutropenia and agranulocytosis. When prescribing the drug to patients with severe disorders of the water-electrolyte balance, this condition should be corrected. During treatment with Kapoten, it is not recommended to take potassium-sparing diuretics or potassium preparations, especially in patients with severe renal impairment.

Angioedema of the extremities, face, lips, mucous membranes, tongue, pharynx or larynx is observed in patients with ACE inhibitors, including captopril. If the swelling is limited to the face and lips, this condition usually resolves after discontinuation of the drug. Antihistamines may be used to relieve clinical symptoms. Patients should be monitored by a doctor until symptoms disappear. If the edema covers the tongue, pharynx or larynx with the threat of airway obstruction,0.5 ml of 0.1% epinephrine solution should be administered subcutaneously.

During treatment with Kapoten, a low-sodium diet is indicated.

Kapoten may cause a false positive reaction in the urine test for acetone.

Use in pediatrics

The safety and efficacy of the drug in children have not been studied.

Form of production

Tablets

Storage conditions

In a dry place, at a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Captopril

Conditions of release from pharmacies

By prescription

Dosage form

Tablets