Cardiomagnil pills 75+15.2mg, 30pcs

Composition

Active ingredients:  acetylsalicylic acid – 75 mg, magnesium hydroxide-15.2 mg. Auxiliary components:  corn and potato starch, microcrystalline cellulose, talc, magnesium stearate, hypromellose, polyethylene glycol. Form of production: Cardiomagnil and cardiomagnil-forte-film-coated tablets, heart-shaped, in dark glass bottles of 30 and 100 pcs

Pharmacological action

The drug Cardiomagnil has an antiplatelet effect, is a nonsteroidal anti-inflammatory agent. The anti-inflammatory effect is associated with irreversible inhibition of cyclooxygenase-1 due to the acetylation reaction. Thromboxane a2 decreases under the influence of acetylsalicylic acid (ASA) as a result of selective inhibition of its synthesis. Probably, there are other mechanisms of reducing platelet aggregation under the action of ASA. Magnesium hydroxide has a protective effect on the gastric mucosa, which is important when taking ASA. ASA is completely absorbed by oral use from the gastrointestinal tract. Hydrolysis to salicylic acid occurs with the participation of esterases in the liver, intestines, and blood plasma. The half-life of ASA is 15 minutes, salicylic acid-3 hours. An additional dose of ASA (more than 3 g) may prolong the half-life of salicylic acid due to the complete saturation of the enzyme systems. The bioavailability of the ASA metabolite, salicylic acid, ranges from 80 to 100%. The bioavailability of ASA is approximately 70%, but this value is very variable due to presystemic hydrolysis in the stomach wall, intestines, and liver tissue. Magnesium hydroxide in the cardiomagnet does not affect the bioavailability of ASA.

Indications

It is used for the prevention of thrombosis in cardiovascular surgery (in the postoperative period after coronary angioplasty, coronary artery bypass grafting). Preventive therapy of increased platelet aggregation in: thrombosis and embolism, coronary heart disease, myocardial infarction, ischemic strokes and circulatory disorders, migraines.

Contraindications

• Kidney failure;• taking methotrexate at a dose of more than 15 mg / week;• under 18 years of age. – a tendency to bleed or a recent episode of bleeding (hemorrhagic diathesis, hemorrhagic stroke, hypothrombinemia, gastrointestinal bleeding, hemophilia);• bronchial asthma in response to the use of ASA• * allergy to the components of the drug (especially ASA);• glucose-6-phosphate dehydrogenase deficiency;

Side effects

Hemorrhagic stroke, gastrointestinal bleeding, allergic reactions, bronchospasm. There may be heartburn, dyspeptic disorders, irritable bowel syndrome, ulcers of the gastrointestinal mucosa, perforation of the existing gastrointestinal ulcer. In a clinical blood test, eosinophilia, a decrease in the number of platelets, aplastic anemia, neutropenia, agranulocytosis are determined. The coagulogram shows hypoprothrombinemia. Rarely there is headache, tinnitus, drowsiness, dizziness.

Interaction

Antacids and colestyramine reduce the absorption of the drug. When used concomitantly, ASA enhances the effect of the following drugs: methotrexate — due to a decrease in renal clearance and its displacement from protein binding; heparin and indirect anticoagulants — due to a violation of platelet function and displacement of indirect anticoagulants from protein binding; thrombolytic and antiplatelet drugs (ticlopidine); digoxin — due to a decrease in its renal excretion; hypoglycemic agents (insulin and sulfonylurea derivatives) — due to the hypoglycemic properties of ASA itself in high doses and the displacement of sulfonylurea derivatives from the bond with proteins; valproic acid — due to its displacement from the bond with proteins. An additive effect is observed when ASA is taken simultaneously with ethanol (alcohol). ASA weakens the effect of uricosuric agents (benzbromarone) due to competitive tubular elimination of uric acid. By increasing the elimination of salicylates, systemic corticosteroids weaken their effect.

How to take, course of use and dosage

1 tablet of cardiomagnil-forte or 2 tablets of cardiomagnil (150 g ASA) on the first day of treatment, then 75 mg (1 tablet of cardiomagnil) 1 time a day. The tablet is washed down with a small amount of water. If necessary, the tablets are chewed or crushed. It is recommended to use after a meal. The duration of treatment is determined by the doctor individually, depending on the clinic, indications and severity of the disease.

Overdose

If signs of overdose are detected, the patient is hospitalized, the stomach is washed, sorption enteral preparations are prescribed, and if necessary, alkaline diuresis is provided. In the future, symptomatic therapy is necessary. If an overdose of cardiomagnil develops tachypnea, the bleeding time is prolonged, nausea, anxiety, tinnitus, sweating, and a decrease in hearing acuity occur. Vomit contains streaks of blood. A dangerous dosage is 150 mg/kg. In severe cases, ketoacidosis, cardiac arrhythmias, hypoglycemia, acute cardiovascular failure, hyperventilation, acute respiratory failure, and coma develop.

Special instructions

Use with caution for gout and hyperuricemia (reduces uric acid excretion). When taking glucocorticoids, it is possible to reduce the level of salicylates in blood plasma, after the withdrawal of glucocorticoids, salicylates increase (the risk of overdose). When taking cardiomagnil, it is necessary to monitor a clinical blood test. Do not apply before surgery and in the postoperative period (risk of bleeding). Patients with diabetes mellitus with prolonged use of cardiomagnil require correction of hypoglycemic agents (ASA causes hypoglycemia). Do not use together with ibuprofen (leveling the therapeutic effect of ASA).

Form of production

Tablets

Storage conditions

The storage area must be protected from children, light and moisture.

Expiration date

Shelf life-5 years at a temperature of not more than 25°C

Active ingredient

: Acetylsalicylic acid, [Magnesium hydroxide]

Dosage form

Tablets

Description

Adults as prescribed by a doctor, Pregnant women only in the second trimester as prescribed by a doctor

Indications

Heart Failure Prevention, Thrombosis Prevention, Angina Pectoris, Heart attack and stroke prevention