Castor Oil, 30ml

Composition

Active ingredient:

castor oil

Pharmacological action

Pharmacokinetics

After ingestion in the alkaline environment of the duodenum in the presence of bile under the influence of lipase, ricinolic acid is formed from the oil. The absorption of ricinolic acid is inversely proportional to the dose taken. When the oil is administered at a dose of 4 g, the absorption of ricinolic acid is about 100%, when administered at a dose of 50 g, only 36% is absorbed (the remaining part of the acid is excreted in the feces within 24 hours), when administered at a dose of 60 g, the proportion of absorbed acid is only 10%. The rate of absorption of ricinolic acid is half the rate of absorption of oleic acid. For the development of a laxative effect, it is necessary to take at least 10 g of oil.

The absorbed part of ricinolic acid undergoes beta-oxidation in the liver and skeletal muscles and is involved in metabolic processes.

Pharmacodynamics

Castor oil is a laxative of vegetable origin.

The mechanism of action of castor oil is associated with ricinolic acid released from it in the lumen of the duodenum. At a concentration of 0.5 mmol/L, ricinolic acid irritates the receptors throughout the intestine and stops the work of Na+ / K+ / 2Cl transporters, as a result, electrolyte absorption stops and water absorption is delayed for the second time. In concentrations of more than 2 mmol/l, ricinolic acid increases the secretion of water into the intestinal lumen.

Under the influence of castor oil, the volume of intestinal contents increases, intestinal motility increases, and its emptying accelerates. The remaining oil in the intestines facilitates the movement of fecal matter through the colon. The laxative effect develops in 2-6 hours after taking the oil and weakens after emptying the intestines.

When the intestinal receptors are irritated, castor oil reflexively stimulates the spinal cord centers that coordinate the contractile activity of the myometrium. As a result, castor oil increases uterine contractions during pregnancy.

Indications

• acute constipation;
• poisoning;
• food intoxication;
• intestinal cleansing before diagnostic procedures;
• weakness of labor forces (as part of complex therapy);
• burns, wounds, skin ulcers, hyperkeratosis;
• to stimulate hair growth.

Contraindications

• individual intolerance;
• chronic constipation;
• acute inflammatory bowel disease (including appendicitis);
• mechanical intestinal obstruction;
• abdominal pain of unknown origin;
• intestinal and uterine bleeding;
• acute and chronic glomerulonephritis;
• tubulointerstitial nephritis;
• toxicity of fat-soluble poisons (including gasoline, carbon tetrachloride extract of male fern);
• pregnancy;
• lactation;
• children’s age (under 12 years).

Side effects

• abdominal pain, nausea;
• digestive disorders, enterocolitis with repeated use;
• hypovitaminosis A and D with repeated use;
• rush of blood to the pelvic organs;
• addiction with repeated use.

Interaction

When used concomitantly, it reduces the absorption of fat-soluble vitamins A, D, and K. In doses up to 4 g/day increases the absorption of fat-soluble drugs-male fern extract, mebendazole, griseofulvin, probucol.

When used simultaneously with saline laxatives, a sharp increase in the laxative effect is possible.

M-anticholinergic agents (atropine sulfate, platifilin, pirenzepine), antispasmodics (papaverine, drotaverine) weaken the effect of castor oil.

Anticholinesterase agents (neostigmine, pyridostigmine, rivastigmine) and glycerin enhance the laxative effect of castor oil.

Enhances the effect of agents that stimulate the contractile activity of the myometrium (methylergometrine, ergometrine, oxytocin, prostaglandins) until the threat of uterine rupture occurs during childbirth.

When applied topically, it increases the percutaneous absorption of drugs applied together with it to the skin.

How to take, course of use and dosage

As a laxative, adults are prescribed 15-30 g 1 time a day. When cleaning the intestines before diagnostic procedures, it is taken 2 to 6 hours before the study is performed. Children aged 12-14 years are prescribed 5-15 g 1 time a day.

If the birth forces are weak, castor oil is prescribed 40-50 g once to stimulate labor activity against the background of the use of drugs that stimulate the contractile activity of the uterus.

In dermatological practice, to soften the skin and remove scales from the foci of excessive keratinization, they are prescribed topically in the form of chatterboxes on ethyl alcohol in a ratio of 1: 10 with the addition of 2% salicylic acid (10 g of castor oil,2 g of salicylic acid, ethyl alcohol up to 100 ml). The talker is rubbed into the lesion 1 time a day for 4 to 7 days, after which the mechanical cleaning of the lesion is carried out and the treatment continues.

In the treatment of burns, skin wounds are prescribed topically in the form of talkers and emulsions in distilled water 1-2 times a day under the dressing.

To enhance hair growth, prepare a solution consisting of 10 g of castor oil and 100 ml of 96% ethyl alcohol, which is rubbed into the scalp.

Overdose

It develops when taking castor oil in a dose of more than 7 g/kg of body weight. It is characterized by the appearance of diarrhea, sharp abdominal cramps, impaired kidney function, dizziness, hallucinations, loss of consciousness.

Specific antidotes are atropine sulfate and loperamide. Treatment measures include drug withdrawal, replacement of fluid and electrolyte losses (preferably combined oral and intravenous use), maintenance and symptomatic therapy aimed at eliminating the resulting disorders. With the development of neurotoxic effects, diazepam 5-10 mg is administered intravenously.

Special instructions

Influence on the ability to drive motor vehicles and manage mechanisms. While taking castor oil, it is not recommended to drive a motor vehicle, you should refrain from other operator activities due to a possible violation of concentration during the onset of the effect.

Caution when using. It is not recommended to use castor oil as a laxative for more than 3 days, since digestion can be disrupted, as well as the absorption of vitamins A and D, with the development of the corresponding hypovitaminosis. It is unacceptable to use castor oil in the treatment of drugs obtained from male fern, because it is possible their systemic absorption and the development of neurotoxic effects.

Form of production

Oil for internal and external use

Storage conditions

In a place protected from light, at a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf life

5 years

Active ingredient

Castor seed oil

Dosage form

oral oil