Celestoderm B with Garamycin, 0.1% ointment, 15g

Composition

Active ingredients:

betamethasone (in the form of valerate) 1 mg,

gentamicin (in the form of gentamicin sulfate) 1 mg

Pharmacological action

Celestoderm-B with garamycin is a combined drug, the action of which is due to the components that make up its composition.

Betamethasone valerate-GCS-has an anti-inflammatory and anti-allergic effect, inhibits the release of cytokines and inflammatory mediators, reduces the metabolism of arachidonic acid, induces the formation of lipocortins with anti-edematous activity, reduces vascular permeability.

Gentamicin, a broad-spectrum antibiotic, is effective against most common pathogens when applied topically. The number of bacteria susceptible to gentamicin includes sensitive strains of streptococcus (beta-hemolytic, alpha-hemolytic), Staphylococcus aureus (coagulase-positive, coagulase-negative and some penicillinase-producing strains), as well as gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae.

Indications

Topical treatment of skin diseases that respond to corticosteroid therapy, in the presence of a secondary infection caused by microorganisms susceptible to gentamicin, or if such an infection is suspected:

• eczema (atonic, children’s, coin-shaped);
• contact dermatitis;
• seborrheic dermatitis;
• neurodermatitis;
• sun dermatitis;
• exfoliative dermatitis;
• radiation dermatitis;
• diaper rash;
• psoriasis;
• anogenital and senile itching.

Celestoderm-B ointment with garamycin is used for skin lesions on the background of eczema or psoriasis, and cream-for diseases of wet or oily skin.

Use during pregnancy and lactation

Due to the fact that the safety of using topical corticosteroids in pregnant women has not been established, the appointment of drugs of this class during pregnancy is justified only if the benefit to the mother clearly exceeds the possible harm to the fetus.

CORTICOSTEROIDS should not be used during pregnancy for a long time or in large doses.

Since it has not yet been established whether corticosteroids can enter breast milk with topical application and systemic absorption, a decision should be made to stop breastfeeding or to discontinue the drug, taking into account how necessary its use is for the mother.

Contraindications

• Hypersensitivity to any of the components of the drug.
• Tuberculosis of the skin.
• Skin manifestations of syphilis.
• Chicken pox.
• Herpes simplex.
• Fungal diseases of the skin.
• Vaccination period and post-vaccination skin reactions.
• Lactation period.
• Pregnancy (long-term treatment of large areas of the skin).
• Children under 6 months of age.

With caution:  

• Pregnancy (if there are no criteria for contraindication), especially in the 1st trimester.
• Long-term treatment of large areas of the skin, especially in children.
• If the skin is cracked or occlusive dressings are used.

How to take, course of use and dosage

Externally. Apply a thin layer on the affected areas of the skin 2 times a day-in the morning and in the evening.

The frequency of use that differs from the recommended one can be determined by the doctor, based on the severity of the disease.

In mild cases, once-daily use is usually sufficient; in more severe cases, more frequent use may also be required.

Overdose

Symptoms:  excessive or prolonged use of topical corticosteroids can cause suppression of the pituitary-adrenal system, which can lead to the development of secondary adrenal insufficiency and the appearance of symptoms of hypercorticism, including Cushing’s syndrome.

A single gentamicin overdose does not cause any symptoms. Long-term use in doses exceeding the recommended ones can lead to a significant increase in insensitive flora, including fungal ones, in the lesion site.

Treatment:  appropriate symptomatic treatment is indicated. Acute symptoms of hypercorticism are usually reversible. If necessary, correction of the electrolyte imbalance is indicated. In case of chronic toxic effects, gradual withdrawal of corticosteroids is recommended. In case of uncontrolled growth of microorganisms, appropriate antibacterial or antifungal treatment should be selected.

Special instructions

If there is no effect from treatment within 2 weeks, it is recommended to consult your doctor to clarify the diagnosis and treatment. If irritation or hypersensitivity is noted during the use of the drug, treatment should be discontinued and another therapy should be selected for the patient.

Any side effects of systemic corticosteroids, including suppression of the adrenal cortex, may also occur with the use of topical corticosteroids, especially in children. Systemic absorption of topical corticosteroids may increase with prolonged use, treatment of large body surfaces, or the use of occlusive dressings, especially in children. Systemic absorption of gentamicin with topical application may increase if applied to large areas of the skin, especially with prolonged treatment or in the presence of skin cracks.

In such cases, the development of adverse events characteristic of gentamicin with its systemic use, especially in children, is possible. With topical application of antibiotics, the growth of insensitive microflora, including fungal, is occasionally observed. In this case, treatment should be stopped and appropriate therapy should be prescribed. Celestoderm-B with Garamycin is indicated only for external use and is not intended for use in ophthalmology.

Celestoderm-B with Garamycin can be used to treat children aged from 6 months. Children may be more susceptible to local corticosteroids that cause hypothalamic-pituitary-adrenal depression than older patients. This is due to the higher absorption of the drug in children due to the higher ratio of surface area and body weight.

Form of production

Ointment for external use.

Storage conditions

Store at a temperature not exceeding 25°C.

Active ingredient

Betamethasone, Gentamicin

Conditions of release from pharmacies

By prescription

Dosage form

ointment

Description

For adults as prescribed by a doctor, Children over 6 months of age, Pregnant women as prescribed by a doctor, Children as prescribed by a doctor

Indications

Psoriasis, Eczema, Diaper Rash, Dermatosis, Allergies, Hives, Neurodermatitis, Dermatitis, Skin Infections