Product description
Minimum order quantity-5 pieces
Composition
Active ingredient:
Chlorhexidine bigluconate 20 g
Auxiliary substances:
 Water up to 100 ml
Pharmacological action
Pharmacotherapy group
Antiseptic and disinfectant.
ATX code: D08AC02
Pharmacological action
Pharmacodynamics
Antiseptic and disinfectant. Depending on the concentration used, it exhibits both bacteriostatic and bactericidal effects. The bacteriological effect of both aqueous and alcoholic working solutions) is manifested in a concentration of 0.01% or less; bactericidal-in a concentration of more than 0.01% at a temperature of 22°C and exposure for 1 min. Fungicidal effect – and at a concentration of 0.05%, at a temperature of 22°C and exposure to 10 minutes. Virucidal effect-manifests itself at a concentration of 0.01-1%.
It is effective against pathogens of sexually transmitted infections-gardnerellosis, genital herpes; gram-positive and gram-negative bacteria-Treponema spp., Neisseria gonorrhoeae, Trichomonas spp., Chlamidia spp., Ureaplasma spp.
It does not work on acid-resistant forms of bacteria, microbial spores, fungi.
It is stable, and after treatment of the skin (hands, surgical field) it remains on it in a certain amount, sufficient for the manifestation of a bactericidal effect. It remains active (although somewhat reduced) in the presence of blood, pus, various secretions and organic substances.
Extremely rarely causes allergic reactions, skin and tissue irritation, and has no damaging effect on objects made of glass, plastic and metals.
Pharmacokinetics
It is practically not absorbed from the gastrointestinal tract. After accidental ingestion of 300 mg, the Cmax is reached in 30 minutes and is 0.206 mcg/l.
It is mainly excreted in the feces (90%), less than 1% is excreted by the kidneys.
Indications
As a preventive and curative agent for various infections, for antiseptic treatment and disinfection.
-0.05%,0.1%,0.2% aqueous solutions:
- Postoperative patient care in ENT and dental
departments-0.05% and 0.2% solutions:
- Purulent wounds, infected burns, bacterial and fungal diseases of the skin and mucous membranes in dentistry (rinsing and irrigation – gingivitis, stomatitis, aphthae, periodontitis, alveolitis);
- Prevention of infections in surgery, urology, obstetrics and gynecology;
- Prevention of sexually transmitted infections (chlamydia, ureplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes-use no later than 2 hours after sexual intercourse); disinfection of the skin (scuffs, cracks).
-0.2% solution:
- Treatment and rehabilitation of the genital tract in gynecology during medical and diagnostic procedures;
- Disinfection of removable dentures.
-0.5% solution:
- Treatment of wounds and burn surfaces; treatment of infected scuffs and cracks of the skin, open mucous membranes.
- Sterilization of medical instruments at a temperature of 70°C.
-1% solution:
- Disinfection of thermometers, work surfaces of medical equipment and devices, heat treatment of which is undesirable;
- Treatment of the surgical field and hands of the surgeon before the operation, disinfection of the skin, treatment of postoperative and burn wounds.
-5% concentrate:
- Preparation of aqueous, glycerol and alcohol solutions with concentrations from 0.01 to 1%.
Contraindications
Hypersensitivity to the components of the drug, dermatitis. With caution – children’s age (under 18 years)
Side effects
In rare cases, allergic reactions (skin rash), dry skin, itching, dermatitis, stickiness of the skin of the hands (within 3-5 minutes), photosensitization may occur.
Discoloration of teeth, tartar deposition and taste disorders in long-term use for oral antiseptics.
Interaction
It is used in a neutral environment; at pH 5-8, the difference in activity is small; at pH more than 8, precipitation occurs. The use of hard water slightly reduces the bactericidal properties.
Chlorhexidine bigluconate is a cationic substance and cannot be combined with soap and other anionic compounds, such as colloids, gum arabic, and carboxymethylcellulose.
At a concentration of 1: 2000, it is incompatible with borates, carbonates, chlorides, citrates, phosphates, and sulfates, creating hard-to-dissolve precipitates after 24 hours.
It is compatible with preparations containing a cationic group (benzalkonium chloride, centrimonium bromide).
Increases the sensitivity of bacteria to chloramphenicol, kanamycin, neomycin, and cephalosporins.
Ethanol increases the effectiveness of the drug.
How to take, course of use and dosage
Chlorhexidine is used as a preventive and therapeutic agent externally and topically, as well as for disinfection.
0.05%,0.02% and 0.5% aqueous solutions are used in the form of irrigation, rinses and applications (5-10 ml is applied to the affected surface of the skin or mucous membranes):
- To treat the surgical field, a 20% solution of 70% ethyl is diluted with an exposure of 1-3 minutes 2-3 times a day (on a swab or by irrigation).
- alcohol in the ratio of 1: 40. The resulting 0.5% water-alcohol solution of chlorhexidine is treated with the surgical field 2 times with an interval of 2 minutes.
- In postoperative care of patients in the ENT and dental departments, a solution (0.05% and 0.1%) for rinsing is usually prescribed 2-3 times a day.
- Complex treatment of urethritis and urethroprostatitis is carried out by injecting 2-3 ml of 0.05% chlorhexidine bigluconate solution into the urethra 1-2 times a day, the course of treatment is 10 days, the procedures are prescribed every other day.
- To wash the bladder, a 0.02% sterile aqueous solution is used during cystoscopy.
- For the prevention of sexually transmitted diseases, chlorhexidine bigluconate is effective if it is applied no later than 2 hours after sexual intercourse.
A diluted,0.05% solution is injected into the urethra of men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml) for 2-3 minutes. It is also necessary to treat the skin of the inner surfaces of the thighs, pubis, and genitals. After the procedure, do not urinate for 2 hours.
For disinfection purposes:
Treatment of medical instruments and working surfaces is carried out with a clean sponge moistened with an antiseptic solution, or by soaking. For rapid sterilization of instruments, apply the same 0.5% solution for 5 minutes.
0.1% water solution of chlorhexidine can also be used for disinfection of premises, sanitary equipment, etc.
Overdose
In case of accidental ingestion, it is practically not absorbed (gastric lavage should be performed using milk, raw egg, gelatin or mild soap). If necessary, symptomatic therapy is performed.
Special instructions
In patients with open craniocerebral trauma, spinal cord injuries, or perforation of the eardrum, avoid contact with the drug on the surface of the brain, meninges, and tympanic cavity.
In case of contact with the mucous membranes of the eyes, they should be quickly and thoroughly rinsed with water.
Concomitant use with iodine is not recommended.
Do not mix chlorhexidine with other disinfectants and detergents. The presence of hypochlorous bleaching agents on fabrics that have previously been in contact with chlorhexidine-containing preparations can contribute to the appearance of brown spots on them.
Clothing that has been in contact with chlorhexidine should not be exposed to hypochlorites or other compounds that emit active chlorine.
Do not dilute with hard water. Aqueous solutions can be sterilized in an autoclave at 116°C for 30 minutes. Do not sterilize with ionizing radiation.
Form of production
Colorless or light yellow transparent liquid
Active ingredient
Chlorhexidine
Dosage form
solution for topical application
Purpose
For pregnant and lactating women, For adults
Indications
Gum disease, Purulent Wounds, Minor Skin Injuries, Female Genital Inflammation, Sore Throat, Disinfection, Fungus, Burns, Wounds, Stomatitis, Tonsillitis, Vaginitis
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