Chloropyramine, ampoules 20mg/ml, 1ml, 5pcs

Composition

>1 ml of solution for intramuscular and intravenous use contains: Active ingredient: chloropyramine hydrochloride 20 mg; excipient: water for injection

Pharmacological action

Pharmaceutical group:

anti-allergic agent-H1-histamine receptor blocker.

Pharmaceutical action:

H1-histamine receptor blocker, has a sedative, hypnotic, antihistamine and m-holinoblokiruyushchy effect, has an antiemetic effect, moderate antispasmodic activity.

Indications

Allergic diseases, including:

• urticaria,
• rhinitis,
• conjunctivitis,
• hay fever,
• angioedema,
• serum sickness,
• drug allergy,

skin diseases, including:

• eczema,
• contact dermatitis,
• pruritus,
• neurodermatitis,
• toxicoderma.

Contraindications

• Individual hypersensitivity to the drug Chloropyramine.
• Simultaneous use of monoamine oxidase inhibitors.
• Newborn babies.
• Pregnancy and lactation.
• Stomach ulcer in the acute stage.
• Angle-closure glaucoma.
• Prostatic hyperplasia.
• Respiratory failure.

The drug should be prescribed with caution to elderly patients, with insufficient liver function and / or heart disease, with peptic ulcer of the gastrointestinal tract, when taking medications that depress the central nervous system.

Side effects

From the central nervous system: lethargy, weakness, drowsiness, dizziness, headache, euphoria, fatigue, irritability, tremor, convulsions, impaired coordination of movements, visual impairment; in children, some stimulating effect on the WYC is possible, manifested by anxiety, increased irritability, insomnia.

From the digestive system: dry mouth, nausea, vomiting, gastralgia, diarrhea/constipation, loss or increased appetite.

From the side of the urethra: difficulty urinating.

From the cardiovascular system: decreased blood pressure (more often in elderly patients), tachycardia, arrhythmia.

From the hematopoietic system: very rarely — leukopenia, agranulocytosis.

From the side of the visual organs: increased intraocular pressure.

Other: photosensitivity, muscle weakness.

Allergic reactions to the drug.

Interaction

Increases the effect of drugs for general anesthesia, sleeping pills, sedatives, tranquilizers, m-holinoblokatorov, opioid analgesics, local anesthetics.

Tricyclic antidepressants and MAO inhibitors enhance the m-holinoblocking and depressing effect on the central nervous system.

Caffeine and phenamine reduce the depressing effect on the central nervous system.

Concomitant use with ethanol is not recommended (risk of severe CNS depression).

How to take, course of use and dosage

Intramuscularly or intravenously.

Adults are prescribed 20-40 mg per day (contents of 1-2 ampoules).

Treatment in children begins with a dose of 5 mg (0.25 ml). In the future, increasing the dose is limited mainly by the appearance of side effects.

Children aged 1-12 months – 5 mg (0.25 ml).

Children aged 2-6 years -10 mg (0.5 ml).

Children aged 7-14 years-10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg / kg of body weight.

If the allergy is severe, treatment should begin with an injectable form of chloropyramine. First, it is administered intravenously slowly, then they switch to intramuscular use and in the final phase of treatment they switch to taking tablets inside.

Overdose

Symptoms: in children – agitation, anxiety, hallucinations, athetosis, ataxia, convulsions, mydriasis, immobility of the pupils, hyperemia of the facial skin, hyperthermia; then-collapse, coma. In adults-depression (lethargy, depression) or agitation of the central nervous system (psychomotor agitation), very rarely-hallucinations, coordination disorders, dilated pupils and lack of their reaction to light, dry mouth, hyperthermia and hyperemia of the skin, convulsions, in severe cases – coma.

Treatment: symptomatic therapy (including prescription of antiepileptic drugs, caffeine, phenamine), resuscitation measures, artificial ventilation of the lungs – according to indications. There is no specific antidote.

Special instructions

During treatment, the use of alcoholic beverages is unacceptable.

Taking the drug overnight may increase the symptoms of reflux esophagitis.

If during prolonged use of the drug there is an unreasonable increase in body temperature, laryngitis, pallor of the skin, jaundice, formation of ulcers of the oral mucosa, the appearance of hematomas, unusual and difficult-to-stop bleeding, you should consult a doctor, since prolonged therapy with antihistamines can lead to hematopoiesis disorders.

Antihistamines can distort the appearance of the reaction when setting skin allergy tests, so a few days before the planned test, the drug should be discontinued.

When combined with ototoxic drugs, chloropyramine may mask early signs of ototoxicity.

Influence on the ability to drive motor vehicles and manage mechanisms

Patients using chloropyramine are advised to refrain from driving vehicles, working with mechanisms, and other activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Solution for intramuscular and intravenous use

Storage conditions

In a dark place, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Chloropyramine

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

For children over 1 month of age, For adults as prescribed by a doctor, For Children as prescribed by a doctor

Indications

Allergies, Allergic Rhinitis, Insect Bites, Pollinosis, Allergic Conjunctivitis, Urticaria, Neurodermatitis, Dermatitis, Eczema