Chlorprothixen Sanofi pills 50mg, 30pcs

Composition

1 film-coated tablet contains:

Active ingredient:

Chlorprothixen hydrochloride 50 mg,

excipients:

corn starch,

lactose monohydrate,

sucrose,

calcium stearate,

talc;

shell composition:

hypromellose 2910/5, macrogol 6000, macrogol 300, talc, opaspray M-1-1-6181 (yellow).

Pharmacological action

The antipsychotic effect of Chlorprothixen is associated with its blocking effect on dopamine receptors. Antiemetic and analgesic properties of the drug are also associated with the blockade of these receptors.

Chlorprothixen is able to block 5-HT2 receptors, α1-adrenergic receptors, and H1-histamine receptors, which determines its adrenoblocking antihypertensive and antihistamine properties.

Pharmacokinetics

The oral bioavailability of Chlorprothixen is about 12%. Chlorprothixen is rapidly absorbed from the intestine, and serum Cmax is reached in 2 hours. T1 / 2 is about 16 hours.

Chlorprothixen penetrates the placental barrier and is excreted in small amounts in breast milk.

The metabolites have no neuroleptic activity and are excreted in the feces and urine.

Indications

Chlorprothixen is a sedative neuroleptic with a wide range of indications, which include:

• psychoses, including schizophrenia and manic States, flowing with psychomotor agitation, agitation and anxiety;
• “hangover” withdrawal syndrome in alcoholism and addictions;
• hyperactivity, irritability, agitation, confusion in elderly patients;
• behavior disorders in children.
• depression, neurosis, psychosomatic disorders;
• insomnia;
• pain (in combination with analgesics).

Use during pregnancy and lactation

Chlorprothixen should not, if possible, be prescribed to pregnant women and during breastfeeding.

Contraindications

• hypersensitivity to the components of Chlorprothixen;
• depression of the central nervous system of any origin (including caused by alcohol, barbiturates or opiates);
• comatose states;
• vascular collapse;
• diseases of the hematopoietic organs;
• pheochromocytoma.

Side effects

Drowsiness, tachycardia, dry mouth, excessive sweating, difficulty accommodating. These side effects, which usually occur at the beginning of therapy, often disappear as it continues.

Orthostatic hypotension may occur, especially when Chlorprothixen is used in high dosages.

Dizziness, dysmenorrhea, skin rashes, constipation are rare. Extrapyramidal symptoms are particularly rare.

Isolated cases of reduced seizure threshold, transient benign leukopenia and hemolytic anemia are described.

With prolonged use, especially in high doses, may occur: cholestatic jaundice, galactorrhea, gynecomastia, decreased potency and / or libido, increased appetite, weight gain.

Interaction

The depressing effect of Chlorprothixen on the central nervous system may be enhanced when taken simultaneously with ethanol and ethanol-containing drugs, anesthetics, opioid analgesics, sedatives, sleeping pills, and neuroleptics. The anticholinergic effect of Chlorprothixen is enhanced by the simultaneous use of anticholinergic, antihistamines and antiparkinsonian agents.

The drug enhances the effect of antihypertensive agents.

Concomitant use of Chlorprothixen and epinephrine may lead to hypotension and tachycardia.

The use of Chlorprothixen leads to a decrease in the threshold of convulsive activity, which requires additional dose adjustment of antiepileptic drugs in patients with epilepsy.

The ability of Chlorprothixen to block dopamine receptors reduces the effectiveness of levodopa.

Extrapyramidal disorders may occur with the simultaneous use of phenothiazines, metoclopramide, haloperidol, and reserpine.

How to take, course of use and dosage

Psychoses, including schizophrenia and manic states.

Treatment begins with 50-100 mg / day, gradually increasing the dose until the optimal effect is achieved, usually up to 300 mg / day. In some cases, the dose may be increased to 1200 mg / day. The maintenance dose is usually 100-200 mg / day. The daily dose of Chlorprothixen Zentiv is usually divided into 2-3 doses, given the pronounced sedative effect of Chlorprothixen Zentiv, it is recommended to prescribe a smaller part of the daily dose in the daytime, and most of it in the evening.

Hangover withdrawal syndrome in alcoholism and drug addiction.

The daily dose, divided into 2-3 doses, is 500 mg. The course of treatment usually lasts 7 days. After the withdrawal symptoms disappear, the dose is gradually reduced. A maintenance dose of 15-45 mg / day helps to stabilize the condition, reduces the risk of developing another binge.

In elderly patients with hyperactivity, irritability, agitation, confusion,15-90 mg/day is prescribed. The daily dose is usually divided into 3 doses.

In children, to correct behavioral disorders, Chlorprothixen Zentiva is prescribed at the rate of 0.5-2 mg/kg of body weight.

Depressive states, neuroses, psychosomatic disorders.

Chlorprothixen Zentiva can be used for depression, especially when combined with anxiety, tension, as an adjunct to antidepressant therapy, or on its own. Chlorprothixen Zentiva can be prescribed for neurosis and psychosomatic disorders accompanied by anxiety and depressive disorders up to 90 mg / day. The daily dose is usually divided into 2-3 doses. Since taking Chlorprothixen Zentiva does not cause the development of addiction or drug dependence, it can be used for a long time.

Insomnia. 15-30 mg in the evening 1 hour before bedtime.

Pain. The ability of Chlorprothixen Zentiv to potentiate the action of analgesics can be used in the treatment of patients with pain. In these cases, Chlorprothixen Zentiva is prescribed together with analgesics in doses from 15 to 300 mg.

Overdose

Symptoms. Drowsiness, hypo-or hyperthermia, extrapyramidal symptoms, convulsions, shock, coma.

Treatment. Symptomatic and supportive treatment. Gastric lavage should be performed as soon as possible, and the use of a sorbent is recommended. Measures should be taken to maintain the functioning of the respiratory and cardiovascular systems. Do not use epinephrine, as this can lead to a subsequent decrease in blood pressure. Seizures can be stopped with diazepam, and extrapyramidal disorders with biperiden.

Special instructions

Chlorprothixen should be used with caution in patients suffering from epilepsy, parkinsonism, severe cerebral vascular atherosclerosis, a tendency to collapse, severe cardiovascular and respiratory failure, severe liver and kidney dysfunction, diabetes mellitus, and prostatic hypertrophy. The use of Chlorprothixen can lead to a false positive result during an immunobiological test of urine for pregnancy, a false increase in the level of bilirubin in the blood, a change in the QT interval on the electrocardiogram. During treatment with the drug, it is recommended to refrain from drinking alcoholic beverages, avoid increased sun exposure.

The effect on the ability to drive motor vehicles and control mechanisms of Chlorprothixene intake has a negative impact on activities that require a high rate of mental and physical reactions (for example, driving vehicles, servicing machines, working at heights, etc. ).

Form of production

Film-coated tablets

Storage conditions

In a dry place, at a temperature of 10-25 °C

Shelf life

3 years

Active ingredient

Chlorprothixen

Conditions of release from pharmacies

By prescription

Dosage form

Tablets