Composition
1 ampoule of lyophilizate for the preparation of a solution for intramuscular use contains:
Active ingredient:
chondroitin sulfate 100 mg
Pharmacological action
Pharmacological action-chondrostimulating, chondroprotective. Participates in the construction of the main substance of cartilage and bone tissue. Improves phosphorus-calcium metabolism in cartilage tissue, inhibits enzymes that disrupt the structure and function of articular cartilage, inhibits the processes of cartilage degeneration. It stimulates the synthesis of glucosaminoglycans, normalizes the metabolism of hyaline tissue, and promotes the regeneration of cartilage surfaces and joint bags. Prevents compression of connective tissue, increases the production of intra-articular fluid, increases the mobility of affected joints. Slows down bone resorption, reduces calcium loss and accelerates bone repair processes, inhibits the progression of osteoarthritis. It has an analgesic effect, reduces joint soreness, pain at rest and when walking, the severity of inflammation, and helps reduce the need for NSAIDs. After oral use, it is rapidly absorbed from the gastrointestinal tract. Cmax is reached in 3-4 hours. It accumulates in the synovial fluid of the joints. Bioavailability is 13%. It is excreted by the kidneys.
Indications
Osteoporosis, paradontopathy, fractures (to accelerate the formation of bone callus), degenerative-dystrophic diseases of the joints and spine.
Contraindications
- Hypersensitivity to chondroitin sulfate,
- tendency to bleeding,
- thrombophlebitis,
- pregnancy, breast-feeding (during treatment, breast-feeding should be discontinued).
Side effects
Allergic reactions, hemorrhages at the injection site.
Interaction
It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics, which requires more frequent monitoring of blood clotting parameters when used together.
How to take, course of use and dosage
Intramuscularly,1 ml every other day. Before use, the contents of the ampoule are dissolved in 1 ml of water for injection. If well tolerated, the dose is increased to 2 ml, starting with the fourth injection. The course of treatment is 25-35 injections. Repeat courses – in 6 months.
The duration of repeated courses of treatment is determined by the doctor. To achieve a stable clinical effect, at least 25 injections of chondroitin sulfate are required, while the effect persists for a long time for many months after the end of the course of treatment. Repeated courses of treatment are indicated to prevent exacerbations.
Form of production
Lyophilizate for the preparation of a solution for intramuscular use
Storage conditions
Store in a dry place, protected from light, at a temperature of 18-22 °C
Shelf life
3 years
Active ingredient
Chondroitin sulfate
Conditions of release from pharmacies
By prescription
Dosage form
solution for injection
Description
For adults as directed by your doctor
Indications
Arthritis, Osteoarthritis, Osteochondrosis, Osteoarthritis
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Side effects of Chondroitin sulfate, Ampoules 100mg, 10pcs.
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