Ciprinol, pills 500mg, 10pcs

Composition

1 tablet contains:

THE CORE:

Active ingredient:  

ciprofloxacin in the form of ciprofloxacin hydrochloride monohydrate 291 mg (which corresponds to ciprofloxacin-250 mg).

Auxiliary substances:

microcrystalline cellulose,

sodium carboxymethyl starch (type A),

povidone,

croscarmellose sodium,

colloidal anhydrous silicon dioxide,

magnesium stearate.

SHELL:  

hypromellose, talc, titanium dioxide, E 171, propylene glycol.

Pharmacological action

Ciprinol refers to antibacterial agents for systemic use. Fluoroquinolones.

Ciprofloxacin inhibits the enzyme DNA gyrase, inhibiting the ability of the bacterium to multiply. The drug has a bactericidal effect on microorganisms both during the breeding season and in the dormant phase.

Ciprinol is highly effective against almost all gram-negative and gram-positive pathogens. Ciprofloxacin is susceptible to: Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli, Citrobacter spp., Enterobacter spp., Hafnia spp., Serratia spp., Edwardsiella spp., Proteus, Providencia spp., Morganella spp., Aeromonasspp., Yersinia, Vibriospp., Haemophilus, Plesiomonas, Campylobacterspp., Pasteurella, Pseudomonasspp. (Including Pseudomonas aeruginosa), Neisseria spp., Legionella, Moraxella spp., Acinetobacter spp., Branhamella spp., Brucella spp., Listeria spp., Staphylococcus spp., Corynebacterium, Chlamydia, and plasmid forms of bacteria.

Different sensitivities show: Gardnerella spp., Streptococcus agalactiae, Alcaligenes spp., Flavobacterium spp., Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Mycoplasma hominis, Streptococcus viridans, Mycobacterium fortuitum, Mycobacterium tuberculosis. Anaerobic cocci (Peptococcus, Peptostreptococcus) are moderately sensitive to ciprofloxacin, while Bacteroides is resistant.

Ciprofloxacin is effective against beta-lactamase-producing bacteria. Ciprinol is active against microorganisms that are resistant to most antibiotics, sulfonamide and nitrofuran preparations. Ciprofloxacin can be active against strains of microorganisms that are resistant to other drugs of the fluoroquinolone group.

However, it should be borne in mind that there is cross-resistance between different fluoroquinolones. As a rule, Nocardia asteroides, Treponema pallidum, Streptococcus faecium, and Ureaplasma urealyticum are resistant to Ciprinol. Resistance to ciprofloxacin develops slowly and gradually.

Indications

• urinary tract infections,
• gonorrhea,
• pneumonia,
• skin and soft tissue
• infections, bone and joint infections,
• intestinal infections,
• barley,
• blood poisoning.

Contraindications

• hypersensitivity to Ciprinol,
• severe renal impairment,
• epilepsy.

Side effects

• allergic reactions
• swelling of the face, vocal cords
• abdominal pain, nausea, vomiting, diarrhea
• sleep disorders, headache, anxiety, general depression
• changes in the blood picture impaired perception of smell and taste.

Interaction

When ciprofloxacin is combined with antacids (which contain aluminum, magnesium, or calcium) or sucralfate, the absorption of ciprofloxacin decreases. Therefore, it is recommended to take ciprofloxacin either 4 hours before the use of antacids or sucralfate, or 2-4 hours after taking it.

Preparations containing iron or zinc reduce the absorption of ciprofloxacin. Concomitant use of ciprofloxacin and theophylline and/or caffeine may cause an increase in serum theophylline and / or caffeine levels and increase their withdrawal time. The risk of these side effects increases. Concomitant use of cyclosporine and ciprofloxacin increases the nephrotoxicity of cyclosporine. It is necessary to control the concentration of theophylline and cyclosporine in serum. The combination of ciprofloxacin and oral anticoagulants may increase bleeding time, so prothrombin time should be monitored.

During treatment with ciprofloxacin, there is a high risk of tendon rupture in patients who are simultaneously undergoing corticosteroid therapy. The combination of ciprofloxacin and phenytoin may lead to changes in the concentration of phenytoin in the serum. Use Ciprinol with extreme caution in the treatment of patients with diabetes mellitus, as the effect of glibenclamide may increase and cause hypoglycemia. Concomitant use with NSAIDs (especially opioid analgesics) and very high doses of quinolones can cause seizures.

How to take, course of use and dosage

For urinary tract infections, take Ciprinol at 0.125-0.5 g 2 times a day, in more severe cases – up to 0.75 g 2 times a day. The course of treatment is usually 5-15 days.

With gonorrhea 0.5 g once. For particularly severe infectious diseases and the inability to take tablets inside, start with intravenous use of the drug Ciprinol.

Overdose

Symptoms include nausea, vomiting, diarrhea, headache, and dizziness, and in more severe cases, confusion, tremors, hallucinations, and seizures.

Treatment: symptomatic, gastric lavage, use of activated charcoal and laxatives; ensure adequate fluid intake. The specific antidote is unknown. Hemodialysis does not have a clinical effect on intoxication.

Special instructions

It should not be administered simultaneously with antacids, the interval between the use of these drugs should be at least 2 hours. During the treatment period, it is necessary to get enough fluids and it is not recommended to sunbathe.

If joint and ligament pain occurs, treatment with Ciprinol should be discontinued. Do not take simultaneously with antiarrhythmic drugs of class I and III, tricyclic antidepressants.

Form of production

Film-coated tablets.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 5 years.

Active ingredient

Ciprofloxacin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Skin Infections, Cholecystitis, Respiratory Tract Infections, Infectious Diseases, Urinary Tract Infections, Prostatitis, Intestinal Infections, Bronchitis, Pneumonia, Urethritis, Sinusitis, Otitis Media, Osteomyelitis, Biliary Tract Infections