Clenzit, gel 0,1%, 15g

Composition

1 gram of gel contains:  

Active ingredient:

Adapalene 1 mg.

Auxiliary substances:

Disodium edetate;

Carbomer 940 (carbopol 940);

Propylene Glycol;

Methylparahydroxybenzoate;

Phenoxyethanol;

Poloxamer 407;

Sodium hydroxide;

Purified water.

Pharmacological action

The Active ingredient of the drug is a retinoid derivative – Adapalene, which exhibits anti-inflammatory and comedonolytic activity. Adapalene takes part in the normalization of the processes of epidermal differentiation and keratinization, inhibits the formation of microcomedones and reduces the manifestations of the inflammatory process.

The mechanism of action of the Active ingredient of the drug Clenzit is its ability to influence specific gamma-receptors of the epidermal cells of the skin, lowering their cohesive surface in the mouths of sebaceous-hair follicles.

In vivo and in vitro studies have shown that Adapalene has a pronounced anti-inflammatory effect, due to its effect on the factors of the inflammatory process. Inhibits arachidonic acid metabolism and leukocyte migration.

When the gel is applied externally, the systemic absorption of its Active ingredient Adapalene is quite low, about 4% of the dose used.

From the systemic circulation, it is excreted by the liver.

Indications

Acne.

Use during pregnancy and lactation

It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

Contraindications

• Hypersensitivity to the components of the drug;
• Pregnancy;
• The period of lactation (breastfeeding).

With caution, the drug should be used for dermatitis, eczema.

Side effects

Dermatological reactions:

skin irritation (treatment should be suspended until the skin irritation disappears or the frequency of application should be reduced).

Interaction

Since adapalene does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as clindamycin phosphate or benzoyl peroxide.

How to take, course of use and dosage

Externally. Before applying the gel, it is necessary to clean and dry the skin of the face. Apply the gel evenly to the affected area with a light touch 1 time / day before going to bed, avoiding contact with the mucous membranes of the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, and a lasting improvement occurs after 3 months of treatment. In some cases, due to short-term skin irritation, treatment may be suspended until the signs of irritation disappear.

A second course of treatment is possible after consulting a doctor.

Overdose

Overdose of the drug is unlikely.

Special instructions

Avoid contact with eyes and lips.

In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water.

Avoid direct sunlight, as skin irritation may occur. Treatment can be continued if the sun exposure is kept to a minimum (using sunglasses and hats).

It is not recommended to use cosmetics with a drying and irritating effect on the skin at the same time (for example, perfume or alcohol-containing products).

Adapalene, applied to the skin in the evening, can be combined with acne medications used in the morning.

Form of production

Gel.

Storage conditions

In a dark place, at temperatures below 25 °C

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Adapalene

Dosage form

gel for external use

Indications

Acne