Condronova, capsules, 30pcs

Composition

1 capsule contains:

Active ingredients:

glucosamine sulfate 250 mg;

chondroitin sulfate 200 mg;

Auxiliary substances:

mannitol;

croscarmellose sodium;

magnesium stearate;

purified talc.

Pharmacological action

Glucosamine sulfate and chondroitin sulfate are involved in the biosynthesis of connective tissue and thus can help prevent the destruction of cartilage and stimulate tissue regeneration.

Glucosamine Sulfate

Glucosamine sulfate is one of the components of the synthesis of hyaluronic acid, which is necessary for the formation of proteoglycans of the structural matrix of joints. Glucosamine sulfate has also been shown to protect articular cartilage from the damaging effects of certain nonsteroidal anti-inflammatory drugs (NSAIDs). The sulfate ion is necessary for the synthesis of glycosaminoglycans, which are esters of sulfuric acid. Ingestion of exogenous glucosamine stimulates the production of the cartilage matrix and provides its non-specific protection. Glucosamine has a certain anti-inflammatory effect.

Chondroitin sulfate

Chondroitin sulfate, regardless of whether it is absorbed in an intact form or in the form of short framgents, serves as an additional substrate for the formation of a healthy cartilage matrix. Chondroitin sulfate (and its derivatives) stimulates the formation of proteoglycans and type II collagen, and also protects the cartilage matrix from enzymatic cleavage (by suppressing the activity of hyaluronidase) and from the damaging effect of free radicals. Chondroitin sulfate supports the viscosity of synovial fluid, stimulates the mechanisms of cartilage repair. Chondroitin sulfate in the treatment of osteoarthritis relieves the symptoms of this disease and reduces the need for NSAIDs.

Pharmacokinetics

Glucosamine

Absorption In humans, the oral bioavailability of glucosamine is 25%.

Distribution After oral dose absorption, radioactively labeled glucosamine is initially detected in plasma components and later penetrates into tissues. The highest concentrations were found in the liver, kidneys, and articular cartilage. About 30% of the dose taken persists for a long time in the tissues of bones and muscles.

Elimination The fraction of glucosamine that is not metabolized or bound to plasma proteins is mainly excreted in the urine. Most of the drug found in feces after oral use is an unabsorbed fraction. The final half-life of the drug bound to plasma proteins is 68 h. Chondroitin sulfate

Absorption When chondroitin sulfate is taken orally once at a dose of 0.8 g (or twice a day at a dose of 0.4 g), the concentration of chondroitin sulfate in plasma increases sharply over 24 hours. Absolute bioavailability is 12%.

Metabolism Chondroitin sulfate is metabolized by desulfurization (after use of low-molecular-weight chondroitin sulfate).

Elimination of chondroitin sulfate is excreted in the urine. The elimination half-life is 310 minutes.

Indications

Osteoarthritis of the peripheral joints and joints of the spine.

Contraindications

• hypersensitivity to the components of the drug;
• diabetes mellitus;
• bronchial asthma;
• childhood;
• pregnancy;
• lactation.

Side effects

Most often

• , mild gastrointestinal disorders (epigastric pain, flatulence, diarrhea, constipation);
• dizziness;
• allergic skin reactions;
• headache;
• leg pain and peripheral edema;
• drowsiness;
• insomnia;
• tachycardia;
• possible allergic reactions;
• exacerbation of bronchial asthma.

Interaction

It is possible to increase the effect of anticoagulants and antiplatelet agents. Increases the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins. The drug is compatible with NSAIDs, painkillers and glucocorticoid drugs.

How to take, course of use and dosage

By mouth. Adults take 2 capsules 2-3 times a day. After 60 days of therapy, the dose should be gradually reduced, depending on the needs of the individual patient.

Course of treatment: 2-3 months (the duration of treatment is determined by the doctor). You can repeat the course of treatment only after consulting your doctor.

Overdose

Cases of overdose of Kondronova® are unknown.

If an overdose occurs, gastric lavage and symptomatic therapy are recommended.

Special instructions

If you are intolerant to seafood, the likelihood of developing allergic reactions increases.

Form of production

Capsules

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 30 °C

Shelf life

2 years

Active ingredient

Glucosamine, Chondroitin Sulfate

Dosage form

Capsules