Cordiamine solution for injection 250mg/ml 1ml ampoules, 10pcs

Composition

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1 ml of the drug contains:

Active ingredient-niketamide 250.0 mg;

auxiliary substance-water for injection up to 1.0 ml

Pharmacological action

Pharmacotherapeutic group: Analeptic agent.

ATX code: R07AB02.

Pharmacological action.

Pharmacodynamics .

Analeptic agent of mixed action. The mechanism of action consists of central and peripheral effects on the nervous system. The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and an indirect increase in blood pressure (especially with the initial suppression of this center). Peripheral exposure is caused by the excitation of chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements. It has no direct effect on the cardiovascular system.

Pharmacokinetics.

Absorption is high and does not depend on the route of use. It undergoes rapid metabolism in the liver with the formation of inactive metabolites, mainly excreted by the kidneys.

Indications

Collapse, asphyxia (including newborns), shock during surgical operations and in the postoperative period, respiratory and circulatory depression in infectious diseases.

Use during pregnancy and lactation

There are no reliable data on the safety of using the drug during pregnancy and lactation. It is not recommended to use this medicine during pregnancy and lactation.

Contraindications

Hypersensitivity to the components of the drug;

Reduction of convulsive threshold, convulsions (including in the anamnesis);

Hyperthermia in children;

Pregnancy and lactation.

Side effects

From the digestive system:  vomiting.

Nervous system disorders:  anxiety, muscle contractions (starting with the circular muscles of the mouth).

From the side of the skin:  itching, flushing of the face.

From the cardiovascular system:  arrhythmia.

Other services:  pain at the injection site, allergic reactions.

Interaction

Enhances the effects of psychostimulants, antidepressants.

Reduces the effect of narcotic analgesics, sleeping pills, antipsychotic and antiepileptic drugs, and anxiolytics.

Reduces the effectiveness of niketamide: aminosalicylic acid, opiniazid, phenothiazine derivatives and drugs for general anesthesia. The convulsive effect of the drug is enhanced by reserpine and aminazine.

The pressor effect of niketamide is enhanced by monoamine oxidase inhibitors.

How to take, course of use and dosage

The drug is administered intravenously, intramuscularly and subcutaneously.

Adults and children over 14 years of age are administered subcutaneously, intramuscularly and intravenously at a dose of 1-2 ml 1-3 times a day.

Intravenous use is carried out slowly.

Children-subcutaneously, depending on age, in a dose of 0.1-0.75 ml.

Since subcutaneous and intramuscular injections of Cordiamine are painful, procaine (Novocaine) 1 ml of 0.5% solution is pre-injected into the site of the intended injection to reduce pain, depending on the situation. The highest doses for adults subcutaneously: single-2 ml, daily-6 ml

Overdose

Symptoms of overdose: increased severity of dose-dependent side effects, generalized tonic-clonic seizures.

Measures to help with overdose: treatment is symptomatic (including anticonvulsant medications).

Description

Clear colorless or slightly yellowish solution with a specific smell.

Storage conditions

Store in a dark place at a temperature not exceeding 25 °C, out of the reach of children.

Shelf

life is 3 years. Do not use after the expiration date indicated on the package.

Active ingredient

Niketamide

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection