Corvalol oral drops Renewal, 25ml

Composition

Per 100 ml of active substances:  Ethylbromisovalerianate (ethyl ether of alpha-bromisovaleric acid) – 2000 Mgphenobarbital-1826 MGM Peppermint leaf oil (peppermint oil) – 142 MGM Auxiliary substances: ethyl alcohol (ethanol) 95% – 79 disodium hydroxide solution 1 M-up to pH 8.0-8.5 purified water – up to 100 ml

Pharmacological action

Combined drug, has a sedative and antispasmodic effect, facilitates the onset of natural sleep. Ethylbromizovalerianate has a sedative and antispasmodic effect due to irritation, mainly of the oral and nasopharyngeal receptors, a decrease in reflex excitability in the central nervous system and increased inhibition in cortical neurons and subcortical structures of the brain, as well as a decrease in the activity of central vasomotor centers and a direct local antispasmodic effect on smooth muscles. Phenobarbital has sedative (in small doses), hypnotic, muscle relaxant and antispasmodic effects, helps to reduce the excitation of the central nervous system (CNS) and facilitates the onset of sleep, increases the sedative effect of other components. Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the “cold” receptors of the oral mucosa and reflexively expand mainly the vessels of the heart and brain. Eliminates the phenomena of flatulence due to irritation of the mucous membrane receptors of the gastrointestinal tract (GIT), increasing intestinal motility.

Indications

As a symptomatic (soothing and vasodilating) agent for functional disorders of the cardiovascular system, neurosis-like conditions accompanied by increased irritability, when falling asleep is disturbed, tachycardia, a state of agitation with pronounced vegetative manifestations; as an antispasmodic agent – for intestinal spasms.

Use during pregnancy and lactation

The use of the drug Corvalol during pregnancy and during breastfeeding is contraindicated, since the drug contains phenobarbital, which penetrates through the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn, penetrates into breast milk, and the development of physical dependence in the newborn is possible. If it is necessary to use during breastfeeding, the question of stopping breast-feeding should be decided.

Contraindications

Hypersensitivity to the components of the drug; severe renal and / or liver dysfunction; alcoholism; traumatic brain injury, brain diseases; pregnancy, breastfeeding; children under 3 years of age. With caution, children from 3 years of age. Impaired liver and kidney function.

Side effects

Drowsiness, dizziness, slowing of the heart rate, decreased ability to concentrate, allergic reactions. Gastrointestinal disorders may occur. These symptoms disappear with a decrease in the dose of the drug or discontinuation of the drug. With prolonged use of the drug, drug dependence, addiction, withdrawal syndrome, as well as bromine accumulation in the body and the development of bromism phenomena (depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements) may occur. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Drugs that depress the central nervous system, enhance the effect of the drug. Phenobarbital (an inducer of microsomal oxidation) can reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucorticosteroids, oral contraceptives); increases the effect of local anesthetics, analgesics and hypnotics. The drug increases the toxicity of methotrexate. The effect of the drug is enhanced against the background of the use of valproic acid preparations.

How to take, course of use and dosage

The dose is set individually. Inside, before eating, pre-dissolved in a small amount (30-50 ml) of water. A single dose in adults is 30 drops, if necessary (for example, with tachycardia), a single dose can be increased to a maximum of 40-50 drops. The frequency of use in adults is 2-3 times a day. In children from 3 years of age,1 drop is used for a year of the child’s life at one reception per day. The need for a second dose is determined by the doctor depending on the clinical picture of the disease. The duration of use of the drug is determined by the doctor individually.

Overdose

Symptoms: depression of the central nervous system( CNS), nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements). Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression – caffeine, niketamide.

Special instructions

1 drop of the drug contains 0.022 g of absolute ethyl alcohol. The maximum single dose of the drug (50 drops) contains 1.1 g of absolute ethyl alcohol, the maximum daily dose (150 drops) contains 3.3 g of absolute ethyl alcohol. Influence on the ability to drive vehicles, mechanisms The drug contains at least 70% by volume of ethanol and phenobarbital, so during the period of taking the drug Corvalol, it is necessary to refrain from driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 1 year.

Active ingredient

: Phenobarbital, Alpha-bromisovaleric acid ethyl ether, Sodium hydroxide, Peppermint oil

Dosage form

oral drops