Cytoflavin, pills, 100pcs

Composition

1 tablet contains:

active ingredients:

succinic acid-0.3 g;

riboxin (inosine) – 0.05 g;

nicotinamide-0.025 g;

riboflavin mononucleotide (riboflavin) – 0.005 g;

excipients:

polyvinylpyrrolidone medium molecular weight (povidone),

calcium stearate,

copolymer of methacrylic acid and ethyl acrylate,

1,2-propylene glycol,

acid red 2C,

Tropeolin O.

Pharmacological action

Pharmacodynamics

Pharmacological effects are due to the complex effect of the components included in the preparation CYTOFLAVIN®. CYTOFLAVIN® promotes the activation of aerobic cell metabolism, which leads to an increase in the level of glucose utilization, contributes to an increased level of beta-oxidation of fatty acids and resynthesis of gamma-aminobutyric acid in neurons.

CYTOFLAVIN ® increases the resistance of nerve and glial cell membranes to the effects of ischemia, which is expressed in a decrease in the concentration of neurospecific proteins that characterize the level of destruction of the main structural components of nervous tissue. CYTOFLAVIN ® improves coronary and cerebral blood flow, activates metabolic processes in the central nervous system, restores disturbed consciousness, promotes regression of neurological symptoms and improves cognitive functions of the brain. It has a rapid awakening effect in post-sarcotic depression of consciousness.

When using CYTOFLAVIN® in the first 12 hours after the onset of stroke, there is a favorable course of ischemic and necrotic processes in the affected area( reduction of the focus), restoration of neurological status and a decrease in the level of disability in the long-term period. Pharmacokinetics

Cytoflavin is highly bioavailable.

Succinic acid, when taken orally, penetrates from the gastrointestinal tract into the blood and tissues, participating in energy metabolism reactions, and completely breaks down to the final metabolic products (carbon dioxide and water) in 30 minutes. Inosine is well absorbed from the gastrointestinal tract. The time to reach the maximum concentration in the blood is 5 hours, the average retention time in the blood is 5.5 hours, and the equilibrium volume of distribution is about 20 liters. Inosine is metabolized in the liver to form inosine monophosphate, followed by its oxidation to uric acid. In a small amount, it is excreted by the kidneys. Nicotinamide is rapidly distributed in all tissues (the equilibrium volume of distribution is about 500 liters). The time to reach the maximum concentration in the blood is 2 hours, the average retention time in the blood is 4.5 hours. Nicotinamide passes through the placenta and into breast milk; it is metabolized in the liver to form N-methylnicotinamide, and is excreted by the kidneys. Riboflavin is rapidly absorbed from the gastrointestinal tract, distributed unevenly (the largest amount in the myocardium, liver, and kidneys), and is transformed into flavinadenine mononucleotide (FMN) and flavinadenine dinucleotide (FAD) in the mitochondria. It passes through the placenta and into breast milk; it is excreted by the kidneys, mainly in the form of metabolites.

Indications

In adults in complex therapy: 1. Acute cerebrovascular accident. 2. Consequences of cerebrovascular diseases (consequences of brain infarction, cerebral atherosclerosis).3. Toxic and hypoxic encephalopathy in acute and chronic poisoning, endotoxicosis, post-sarcotic depression of consciousness, as well as for the prevention and treatment of hypoxic encephalopathy in cardiac surgery using artificial blood circulation. In children (including preterm children with a gestational age of 28-36 weeks) in complex therapy in the neonatal period: 1. In case of cerebral ischemia.

Contraindications

Hypersensitivity, in patients on mechanical ventilation, with a decrease in the partial pressure of oxygen in arterial blood less than 60 mm Hg, during breastfeeding.

With caution – nephrolithiasis, gout, hyperuricemia.

Side effects

Headache, pain or discomfort in the epigastric region.

Possible allergic reactions in the form of skin hyperemia and itching. Adverse reactions include: transient hypoglycemia, hyperuricemia, exacerbation of concomitant gout.

If any of the side effects listed in the instructions get worse or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Succinic acid, inosine, and nicotinamide are compatible with other medications.

Riboflavin reduces the activity of some antibiotics (tetracyclines, erythromycin, lincomycin), is incompatible with streptomycin.

Ethanol, tricyclic antidepressants, and tubular secretion blockers reduce the absorption of riboflavin, and thyroid hormones accelerate its metabolism.

How to take, course of use and dosage

Inside 2 tablets 2 times a day with an interval between doses of 8-10 hours. Tablets should be taken at least 30 minutes before meals, without chewing, with water (100 ml).

It is recommended to take the drug in the morning and afternoon (no later than 18 hours).

The duration of treatment is 25 days. The appointment of a second course is possible with an interval of at least 1 month.

Overdose

To date, no cases of overdose with CYTOFLAVIN have been established.

Special instructions

In case of hypertension, it may be necessary to adjust the doses of antihypertensive drugs.

In patients with diabetes mellitus, treatment should be carried out under the control of blood glucose concentration.

Intense yellow staining of urine is possible.

CYTOFLAVIN does not affect: the ability to drive vehicles, work with moving mechanisms, the work of dispatchers and operators.

Form of production

coated tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Inosine, Nicotinamide, Riboflavin, Succinic acid

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Consequences of stroke, Atherosclerosis, Impaired cerebral circulation