Detralex pills 1000mg, 30pcs

Composition

1 tablet contains a purified micronized flavonoid fraction of 1000 mg, including:  

• diosmin 900 mg (90%)
• flavonoids in terms of hesperidin 100 mg (10%)

30 tablets for oral use in a package

Pharmacological action

Detralex has venotonizing and angioprotective properties. The drug reduces the dilatability of veins and venous congestion, reduces the permeability of capillaries and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to venous hemodynamic parameters.

A statistically significant dose-dependent effect of Detralex was demonstrated for the following venous plethysmographic parameters: venous capacity, venous extensibility, and venous emptying time.

The optimal dose-effect ratio is observed when taken at a dose of 1000 mg per day.

Detralex increases venous tone: venous occlusal plethysmography showed a reduction in the time of venous emptying. In patients with signs of severe microcirculation disorders, after therapy with Detralex, an increase in capillary resistance (statistically significant, compared with placebo), estimated by angiostereometry, is noted.

The therapeutic efficacy of Detralex in the treatment of chronic venous diseases of the lower extremities, as well as in the treatment of hemorrhoids, has been proven.

Indications

Detralex is indicated for the treatment of symptoms of chronic venous diseases (elimination and relief of symptoms).

• Treatment of symptoms of venous-lymphatic insufficiency:
  • pain;
  • cramps of the lower extremities;
  • feeling of heaviness and bursting in the legs;
  • ” fatigue ” of the legs.
• Treatment of venous-lymphatic insufficiency manifestations:
  • edema of the lower extremities;
  • trophic changes in the skin and subcutaneous tissue;
  • venous trophic ulcers.
• Symptomatic treatment of acute and chronic hemorrhoids.

Contraindications

• hypersensitivity to the active ingredients or excipients that make up the drug.
• due to the lack of data on the excretion of the drug in breast milk, lactating women are not recommended to take the drug.

Side effects

Side effects of Detralex® observed in clinical trials were mild in severity. Mainly there were gastrointestinal disorders (diarrhea, dyspepsia, nausea, vomiting).

When taking Detralex®, the following side effects have been reported in the following gradation: very common (≥1/10), common (≥1/100, <1/10), infrequent (≥1/1000, <1/100), rare (≥1/10 000, <1/1000), very rare (

From the central nervous system:  rarely – dizziness, headache, general malaise.

From the gastrointestinal tract:  often – diarrhea, dyspepsia, nausea, vomiting; infrequently-colitis; unspecified frequency-abdominal pain.

From the side of the skin:  rarely-rash, pruritus, urticaria; unspecified frequency-isolated swelling of the face, lips, eyelids; in exceptional cases-angioedema.

The patient should be informed that if any adverse reactions and sensations occur during therapy, including those not mentioned in the instructions, as well as changes in laboratory parameters, the doctor should be informed.

Interaction

Drug interactions with Detralex® have not been reported.

You should inform the attending physician about all medications taken by the patient.

How to take, course of use and dosage

The drug is prescribed inside.

The recommended dose for venous-lymphatic insufficiency is 1 tablet/day, preferably in the morning, with meals.

The label on the tablet is intended solely for division in order to facilitate ingestion.

The duration of the course of treatment can be several months (up to 12 months). In case of recurrent symptoms, the course of treatment may be repeated on the doctor’s recommendation.

The recommended dose for acute hemorrhoids is 3 tablets/day (1 tablet each). morning, afternoon and evening) for 4 days, then-2 tablets/day (1 tablet each). morning and evening) for the next 3 days.

The recommended dose for chronic hemorrhoids is 1 tablet/day.

Overdose

Cases of overdose are not described.

In case of overdose of the drug, the patient should immediately seek medical attention.

Special instructions

Before using Detralex®, the patient is recommended to consult a doctor.

In case of acute hemorrhoids, the use of Detralex® does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section “Dosage regimen”. In the event that the symptoms do not disappear after the recommended course of therapy, you should conduct an examination with a proctologist, who will select further therapy.

In the presence of venous circulatory disorders, the maximum effect of treatment is provided by combining therapy with a healthy (balanced) lifestyle: it is advisable to avoid long exposure to the sun, long stay on your feet, and it is also recommended to reduce excess body weight. Walking and, in some cases, wearing special stockings helps to improve blood circulation.

The patient should immediately consult a doctor if the condition worsens or does not improve during treatment.

The drug does not affect the ability to drive vehicles and perform work that requires a high rate of mental and physical reactions.

Active ingredient

Hesperidin, Diosmin

Dosage form

Tablets

Description

For pregnant women as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Varicose veins, Trophic ulcers, Hemorrhoids