Detralex suspension for oral use 1000mg/10ml sachet 10ml, 30pcs

Composition

: 1 sachet (10 ml)

purified micronized flavonoid fractions 1000 mg, including diosmin 900 mg (90%), flavonoids in terms of hesperidin 100 mg (10%)

Auxiliary substances:

citric acid-12.5 mg,

orange flavor-15 mg,

maltitol-1800 mg,

sodium benzoate-15 mg,

xanthan gum-50 mg,

purified water q. s. – up to 10 ml

Pharmacological action

Detralex® has venotonizing and angioprotective properties. The drug reduces the dilatability of veins and venous congestion, reduces the permeability of capillaries and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to venous hemodynamic parameters.

A statistically significant dose-dependent effect of Detralex® was demonstrated for the following venous plethysmographic parameters: venous capacity, venous extensibility, and venous emptying time. The optimal dose-effect ratio is observed when taking 1000 mg / day.

Detralex ® increases venous tone: venous occlusal plethysmography has been shown to reduce the time of venous emptying. In patients with signs of severe microcirculation disorders after treatment with Detralex®, an increase in capillary resistance (statistically significant, compared with placebo), estimated by angiostereometry, is noted.

The therapeutic efficacy of Detralex® in the treatment of chronic venous diseases of the lower extremities, as well as in the treatment of hemorrhoids, has been proven.

Detralex ® reduces undesirable side effects of invasive methods of treatment of chronic venous diseases (reduces the frequency of undesirable side effects in surgical and endovascular treatment of varicose veins: significantly reduces the intensity of postoperative pain, edema and severity of hemorrhages after endovascular and surgical treatment).

Pharmacokinetics

The main elimination of the drug occurs in the feces. On average, about 14% of the amount of the drug taken is excreted in the urine. T1 / 2 is 11 hours.

The drug undergoes an active metabolism, which is confirmed by the presence of phenolic acids in the urine.

Indications

Detralex® is indicated for the treatment of symptoms of chronic venous diseases (elimination and relief of symptoms).

Treatment of symptoms of venous-lymphatic insufficiency:

— pain;

– cramps of the lower extremities;

– feeling of heaviness and bursting in the legs;

—” fatigue ” of the legs.

Treatment of venous-lymphatic insufficiency manifestations:

— edema of the lower extremities—

– trophic changes in the skin and subcutaneous tissue—

– venous trophic ulcers.

Symptomatic treatment of acute and chronic hemorrhoids.

Contraindications

-hypersensitivity to the Active ingredient or excipients that make up the drug;

– fructose intolerance.

It is not recommended to take the drug for lactating women.

Side effects

Side effects of Detralex® observed in clinical trials were mild in severity. Mainly there were gastrointestinal disorders (diarrhea, dyspepsia, nausea, vomiting).

When taking Detralex®, the following side effects were reported in the form of the following gradation: very common (>1/10), often (>>1/100,1/1000,1/10 000, >>

From the central nervous system: rarely-dizziness, headache, general malaise.

From the gastrointestinal tract: often – diarrhea, dyspepsia, nausea, vomiting; infrequently-colitis; unspecified frequency-abdominal pain.

From the skin: rarely-skin rash, pruritus, urticaria; unspecified frequency-isolated swelling of the face, lips, eyelids; in exceptional cases-angioedema.

The patient should inform the doctor about the occurrence of any adverse reactions and sensations, including those not mentioned in the instructions, as well as changes in laboratory parameters during therapy.

Interaction

Drug interactions with Detralex® have not been reported.

The patient should inform the attending physician about all medications taken.

How to take, course of use and dosage

The drug is taken orally.

The recommended dose for venous-lymphatic insufficiency is 1000 mg (contents of 1 sachet). /day, preferably in the morning, during meals.

The duration of the course of treatment can be several months (up to 12 months). In case of recurrent symptoms, the course of treatment may be repeated on the doctor’s recommendation.

The recommended dose for acute hemorrhoids is 3000 mg / day (1000 mg (contents of 1 sachet) in the morning, afternoon and evening) for 4 days, then 2000 mg/day (1000 mg (contents of 1 sachet) in the morning and evening) for the next 3 days.

The recommended dose for chronic hemorrhoids is 1000 mg (contents of 1 sachet). /day at any convenient time of the day along with a meal.

Overdose

Cases of overdose are not described.

In case of overdose of the drug, the patient should immediately seek medical attention.

Special instructions

Before using Detralex®, the patient is recommended to consult a doctor.

In case of acute hemorrhoids, the use of Detralex® does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section “Dosage regimen”. In the event that the symptoms do not disappear after the recommended course of therapy, you should be examined by a proctologist, who will select further therapy.

In the presence of venous circulatory disorders, the maximum effect of treatment is provided by combining therapy with a healthy (balanced) lifestyle; it is advisable to avoid long exposure to the sun, prolonged exposure to the feet, and it is also recommended to reduce excess body weight. Hiking and, in some cases, wearing special stockings (compression knitwear) helps to improve blood circulation.

The patient should immediately consult a doctor if the condition worsens or does not improve during treatment.

Influence on the ability to drive motor vehicles and manage mechanisms

The drug does not affect the ability to drive a car and perform work that requires a high rate of mental and physical reactions.

Form of production

The suspension for oral use is homogeneous, light yellow in color, with a characteristic odor.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 30°C.

Shelf

life is 3 years.

Active ingredient

Hesperidin, Diosmin

Dosage form

suspension for oral use

Description

For pregnant women as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Hemorrhoids, Varicose veins, Trophic ulcers