Detravenol pills 500mg, 30pcs

Composition

For 1 tablet:

• Active ingredient:  purified micronized flavonoid fraction, including: diosmin (90%) – 450,000 mg; flavonoids in terms of hesperidin (10%) – 50,000 mg
• . excipients (core): gelatin – 13,500 mg, sodium carboximetilkrahmal -27,000 mg, magnesium stearate – 6,500 mg, microcrystalline cellulose – up to 650,000 mg.
• the composition of the shell: Opadry II 85F240012 Pink -20,000 mg: polyvinyl alcohol – 8.000 mg, macrogol-3350 – 4,876 mg, dye iron oxide red – 0.080 mg, dye iron oxide yellow – 0,044 mg, talc – 2,960 mg, titanium dioxide – 4,040 mg.

Pharmacological action

The combination of hesperidin + diosmin has venotonizing and angioprotective properties. Reduces the extensibility of the veins and venous congestion, in the microcirculation – reduces the permeability of capillaries and increases their resistance, improves the indicators of venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous extensibility, and venous emptying time. The optimal effect is achieved when taking 1000 mg. The combination of hesperidin + diosmin increases venous tone by reducing the time of venous emptying. In patients with signs of severe microcirculation disorders, an increase in capillary resistance is noted. The combination of hesperidin + diosmin is effective in the treatment of chronic diseases of the veins of the lower extremities, as well as in the treatment of hemorrhoids.

Pharmacokineticspreparation Detravenol is mainly excreted through the intestine. On average, about 14% of the drug dose is excreted by the kidneys. The elimination half-life is 11 hours. The drug undergoes an active metabolism, which is confirmed by the presence of phenolic acids in the urine.

Indications

Treatment of symptoms of chronic venous diseases (elimination and relief of symptoms). Treatment of symptoms of venous-lymphatic insufficiency:

• pain;
• cramps of the lower extremities;
• feeling of heaviness and bursting in the legs;
• ” fatigue ” of the legs.

Treatment of venous-lymphatic insufficiency manifestations:

• edema of the lower extremities;
• trophic changes in the skin and subcutaneous tissue;
• venous trophic ulcers.

Symptomatic treatment of acute and chronic hemorrhoids.

Contraindications

• Hypersensitivity to the components of the drug;
• Breast-feeding period (limited experience).

Side effects

The frequency of side effects is determined in accordance with the WHO classification of adverse drug reactions by frequency of occurrence; very often more than 1/10, often more than 1/100 and less than 1/10, infrequently more than 1/1000 and less than 1/100, rarely more than 1/10000 and less than 1/1000, very rarely less than 1/10000, including isolated cases; unknown frequency (it is impossible to determine the frequency of occurrence of an adverse reaction from the available data). From the central nervous system: rarely-headache, dizziness, general malaise. From the gastrointestinal tract: often-diarrhea, dyspepsia, nausea, vomiting; infrequently-colitis; unspecified frequency-abdominal pain. From the skin and subcutaneous fat: rarely – skin rash, pruritus, urticaria; unspecified frequency-isolated swelling of the face, lips, eyelids; in exceptional cases-angioedema. If you experience any of the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

How to take, course of use and dosage

Inside. The recommended dose for venous-lymphatic insufficiency is 2 tablets per day, preferably in the morning, with meals. The duration of the course of treatment can be several months (up to 12 months). In case of recurrent symptoms, the course of treatment may be repeated on the doctor’s recommendation. The recommended dose for acute hemorrhoids is 6 tablets per day (3 tablets in the morning and 3 tablets in the evening) for 4 days, then 4 tablets per day (2 tablets in the morning and evening) for the next 3 days. The recommended dose for chronic hemorrhoids is 2 tablets per day.

Overdose

Cases of overdose are not described. If you overdose, seek immediate medical attention!

Special instructions

Before you start taking Detravenol, it is recommended to consult your doctor. In case of hemorrhoid exacerbation, the use of Detravenol does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section “Dosage and use”. In the event that the symptoms do not disappear after the recommended course of therapy, you should be examined by a proctologist, who will select further therapy. In the presence of venous circulatory disorders, the maximum effect of treatment is provided by combining therapy with a healthy (balanced) lifestyle, it is advisable to avoid long exposure to the sun, prolonged exposure to the feet, and also, it is recommended to reduce excess body weight. Hiking and. in some cases, wearing special stockings helps to improve blood circulation. If there is no reduction or if the symptoms of the disease become more severe, consult your doctor!

Do not exceed the maximum time and recommended doses of the drug without consulting your doctor!

Influence on the ability to drive vehicles and mechanisms

The drug does not affect the ability to drive vehicles and mechanisms.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Purified micronized flavonoid fraction (diosmin, flavonoids in terms of hesperidin)

Dosage form

Tablets

Description

For pregnant women, For adults

Indications

Varicose veins, Trophic ulcers, Hemorrhoids