Dezal pills 5mg, 10pcs

Composition

Active ingredient:  desloratadine 5 mg;

Auxiliary substances:  microcrystalline cellulose, pregelatinized corn starch, mannitol, talc, magnesium stearate

Pharmacological action

Dezal is a long-acting histamine H1-receptor blocker. It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and eases the course of allergic reactions. It has anti-allergic, antipruritic and anti-exudative effects. Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm. It has practically no sedative effect and when taken at a dose of 7.5 mg does not affect the speed of psychomotor reactions. In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs at comparable doses (taking into account the concentration of desloratadine).

Pharmacokinetics

After oral use, it begins to be determined in plasma after 30 minutes. Food does not affect the distribution. Bioavailability is proportional to the dose in the range from 5 mg to 20 mg. Binding to plasma proteins is 83-87%. It does not cross the blood-brain barrier (BBB). Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide, only a small part of the oral dose is excreted by the kidneys (less than 2%) and in the faeces (less than 7%).

Indications

Symptomatic treatment of seasonal and year-round allergic rhinitis, chronic idiopathic urticaria.

Use during pregnancy and lactation

use of the drug during pregnancy is not recommended due to the lack of clinical data on the safety of its use during this period.

Desloratadine is excreted in breast milk, so its use during breastfeeding is not recommended.

Contraindications

Hypersensitivity

Side effects

Mental disorders:  hallucinations. From the central nervous system:  dizziness, drowsiness, insomnia, psychomotor hyperactivity. From the cardiovascular system:  tachycardia, palpitation of the heart. From the digestive system:  abdominal pain, nausea, vomiting, dyspepsia, diarrhea. Liver and biliary tract disorders:  increased activity of liver enzymes, increased bilirubin concentration, hepatitis. Musculoskeletal disorders:  myalgia. Allergic reactions:  anaphylaxis, angioedema, pruritus, rash, urticaria.

Interaction

There were no clinically significant interactions with other drugs (including ketoconazole and erythromycin).

Desloratadine does not enhance the effect of ethanol on the central nervous system.

How to take, course of use and dosage

Inside, regardless of food intake. Adults and adolescents (12 years and older) – 5 mg (1 tablet) 1 time a day.

Overdose

Symptoms: taking a dose 9 times higher than the recommended dose (45 mg) did not result in any clinically significant symptoms. Drowsiness may develop.

Treatment: it is necessary to wash the stomach, take activated charcoal; if necessary, symptomatic therapy. Desloratadine is not eliminated by hemodialysis, and the effectiveness of peritoneal dialysis has not been established.

Special instructions

In case of severe renal impairment, Desal should be taken with caution.

No effect of desloratadine on driving has been observed in studies. However, it should be borne in mind that very rarely some patients may develop drowsiness, in this case, care should be taken when driving vehicles and when working with mechanisms.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Desloratadine

Dosage form

Tablets

Description

For adults, Children over 12 years of age

Indications

Pollinosis, Allergy, Allergic Rhinitis, Runny Nose, Conjunctivitis, Diathesis, Urticaria, Allergic Conjunctivitis, Dermatitis