Diara, 2mg Chewable tablets 12pcs

Composition

Active ingredient:

loperamide hydrochloride 2.0 mg.

Auxiliary substances:

polymethylsiloxane,

potato starch,

lactose (milk sugar),

sucrose (sugar) microcrystalline cellulose,

colloidal silicon dioxide (aerosil),

aspartame,

povidone (Collidone 90),

xylitol (Xylitab 300),

lactitol, collidone SR,

menthol,

magnesium stearate,

anise oil.

Pharmacological action

Diarrhoea is an antidiarrheal agent.

Loperamide binds to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons via guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins).

Slows down peristalsis and increases the passage time of intestinal contents.

Increases the tone of the anal sphincter, helps to retain fecal matter and reduce the urge to defecate.

The action comes quickly and lasts 4-6 hours.

Indications

• Symptomatic treatment of acute and chronic diarrhea of various origins (allergic, emotional, medicinal, radiation);
• when changing the diet and quality of food, with impaired metabolism and absorption;
• as an auxiliary agent for diarrhea of infectious origin;
• stool regulation in patients with ileostoma.

Use during pregnancy and lactation

Diara is not recommended for use during pregnancy, lactation, and children under 6 years of age.

Contraindications

• Hypersensitivity to the drug;
• diverticulosis;
• intestinal obstruction;
• ulcerative colitis in the acute stage;
• diarrhea against the background of acute pseudomembranous enterocolitis;
• as monotherapy for dysentery and other infections of the gastrointestinal tract(GIT);
• pregnancy (I trimester) and lactation;
• children under 6 years of age.

With caution:  liver failure.

Side effects

Gastralgia, dry mouth, allergic reactions ( skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, constipation.

Extremely rare – intestinal obstruction.

How to take, course of use and dosage

Inside, chewing, washing down with water.

Adults with acute and chronic diarrhea are prescribed an initial dose of 2 tablets (4 mg); then 1 tablet (2 mg) after each act of defecation (in the case of loose stools); the maximum daily dose is 8 tablets (16 mg).

Children over 6 years of age with acute diarrhea are prescribed an initial dose of 1 tablet (2 mg), then 1 tablet after each act of defecation (in the case of loose stools); the maximum daily dose is 3 tablets (6 mg).

If the stool is normal or if there is no stool for more than 12 hours, treatment with Diara should be discontinued.

Overdose

Symptoms:  depression of the central nervous system ( CNS) – stupor, impaired coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression; intestinal obstruction.

Treatment:  the antidote is naloxone; given that the duration of action of loperamide is longer than that of naloxone, repeated use of the latter is possible.

Symptomatic treatment:  activated charcoal, gastric lavage, artificial lung ventilation. Medical supervision is required for at least 48 hours.

Special instructions

If there is no effect within 48 hours, the drug should be discontinued and a doctor should be consulted.

Form of production

Chewable tablets

Storage conditions

Store in a dry place protected from light at a temperature not exceeding 25°C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Loperamide

Dosage form

tablets for resorption

Description

Pregnant women in the second and third trimester as prescribed by a doctor, Children over 6 years of age, For adults

Indications

Diarrhea