Dimexid gel for external use 25%, 30g

Composition

Active ingredient:

dimexide (dimethyl sulfoxide)25 g;

Auxiliary substances:

methylparahydroxybenzoate (nipagin) — 0.05 g;

propylparahydroxybenzoate (nipazole) – 0.013 g;

carmellose sodium (sodium carboxymethylcellulose — – 2 g;

purified water-up to 100 g

Pharmacological action

Dimexide is an anti-inflammatory agent that has a local analgesic and anti-inflammatory effect. It has a moderate antiseptic and fibrinolytic effect.

Dimethyl sulfoxide inhibits inflammatory tissue infiltration. In addition, dimethyl sulfoxide contributes to the normalization of fibrin formation processes, increases microcirculation in tissues, inhibits red blood cell aggregation, increases phagocyte activity, suppresses neutrophil chemotaxis, and reduces the content of circulating immune complexes.

Penetrates through the skin, mucous membranes, bacterial cell wall (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs. The drug is low-toxic.

Pharmacokinetics

When applying the drug, dimethyl sulfoxide is detected in the blood serum after 8-15 minutes, and the maximum content is noted after 2-8 hours. As a rule, after 30-36 hours, dimethyl sulfoxide in the blood serum is no longer detected. Dimethyl sulfoxide does not accumulate. When applied topically, dimethyl sulfoxide penetrates the joint cavity, binds to proteins in the blood and tissues.

It is excreted from the body through the kidneys unchanged and in the form of oxidation products-dimethylsulfone and dimethylsulfate; as well as in the form of a reduced product (dimethylsulfide) is released with exhaled air.

Indications

To relieve pain in the complex therapy of the following diseases and conditions:

• rheumatoid arthritis;
• ankylosing spondylitis;
• deforming osteoarthritis;
• arthropathy;
• sciatica;
• trigeminal neuralgia;
• bruising treatment;
• ligament damage;
• traumatic infiltrates;
• erythema nodosum therapy.

Contraindications

• hypersensitivity to Dimexide or other components of the drug;
• severe liver and kidney damage;
• angina pectoris;
• myocardial infarction;
• severe atherosclerosis;
• various types of stroke;
• glaucoma, cataracts;
• coma;
• pregnancy;
• lactation;
• children under 12 years of age.

With caution:  due to the fact that Dimexide can increase not only the activity, but also the toxicity of certain drugs, caution should be exercised when prescribing it simultaneously with other drugs.

Side effects

During the application of the drug, contact dermatitis, garlic smell of exhaled air, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, and a slight burning sensation may occur.

Some patients do not perceive the smell of the drug well (nausea, vomiting), in some cases bronchospasm is possible.

If any of the side effects listed in the instructions have worsened or any other side effects not listed in the instructions have appeared, you should inform your doctor.

Interaction

Increases the penetration of drugs (NSAIDs, antibiotics, etc. ) through the skin, which leads to an increase in their activity, in some combinations — to toxicity.

How to take, course of use and dosage

Externally.

For adults and children over 12 years of age, the drug is applied in a thin layer to the affected area 1-2 times a day.

The duration of treatment is 10-14 days.

Repeat courses can be held in at least 10 days.

Overdose

Symptoms:  increased dose-dependent side effects.

Treatment:  in these cases, the drug should be discontinued, the damaged area should be washed, and the drug should be removed.

Special instructions

Given the possibility of individual intolerance to the drug, it is recommended to conduct a drug tolerance test for it.

To do this, the gel is applied in a thin layer to the skin of the elbow bend.

The appearance of sharp redness and itching indicates hypersensitivity to Dimexide.

If allergic reactions occur during treatment with the drug, the use of the drug is discontinued, _H1-histamine receptor blockers are prescribed.

Product form

gel for external use

Storage conditions

At a temperature not exceeding 25 °C.

Shelf life

2 years

Active ingredient

Dimethyl Sulfoxide

Dosage form

gel for external use

Description

For adults, Children over 12 years of age

Indications

Arthritis, Bruises, Bruises, Osteoarthritis, Rheumatoid Arthritis, Osteoarthritis